Data Mining of Supersecondary Structure Homology between Light Chains of Immunogloblins and MHC Molecules: Absence of the Common Conformational Fragment in the Human IgM Rheumatoid Factor

2013 ◽  
Vol 53 (3) ◽  
pp. 584-591 ◽  
Author(s):  
Hiroshi Izumi ◽  
Akihiro, Wakisaka ◽  
Laurence A. Nafie ◽  
Rina K. Dukor
Keyword(s):  
Data Mining ◽  
Rheumatoid Factor ◽  
Light Chains ◽  
Mhc Molecules ◽  
Igm Rheumatoid Factor ◽  
The Common

scholarly journals Human rheumatoid factor crossidiotypes. I. WA and BLA are heat-labile conformational antigens requiring both heavy and light chains.

1986 ◽  
Vol 164 (5) ◽  
pp. 1809-1814 ◽  
Author(s):  
V Agnello ◽  
J L Barnes
Keyword(s):  
Rheumatoid Factor ◽  
Primary Structure ◽  
Binding Activity ◽  
Light Chains ◽  
Heat Denaturation ◽  
Antigen Binding ◽  
Rheumatoid Factors ◽  
Simple Method ◽  
Heat Labile

Evidence was obtained that both the WA and BLA crossidiotype (XId) groups are conformational antigens requiring both L and H chains and that with heat denaturation the antigens that define the XIds and antigen-binding activity are lost in parallel. In contrast, the primary structure-dependent crossreactive idiotype (CRI), PSL2, which is only weakly detected on native Wa and Bla monoclonal rheumatoid factors (mRFs), became prominently detected on the heated Wa and Bla mRFs. Heat denaturation may provide a simple method for distinguishing Ids determined by conformational antigen from primary structure-dependent Ids. In addition to heat denaturation, some acid conditions commonly used for preparation of RFs were also found to cause marked loss of Id antigen. The finding of PSL2-CRI on Bla mRF indicates that this Id is not unique to the WA XId.

scholarly journals Estimation of the relative avidity of 19S IgM rheumatoid factor secreted by rheumatoid synovial cells for human IgG subclasses

1986 ◽  
Vol 29 (6) ◽  
pp. 722-729 ◽  
Author(s):  
Dick L. Robbins ◽  
Jeffrey Skilling ◽  
William F. Benisek ◽  
Richard Wistar
Keyword(s):  
Rheumatoid Factor ◽  
Igg Subclasses ◽  
Synovial Cells ◽  
Human Igg ◽  
Igm Rheumatoid Factor

Data Mining with Incomplete Data

2011 ◽  
pp. 293-296 ◽  
Author(s):  
Hai Wang ◽  
Shouhong Wang
Keyword(s):  
Data Mining ◽  
Missing Data ◽  
Survey Data ◽  
Incomplete Data ◽  
Knowledge Engineering ◽  
Data Set ◽  
Survey Question ◽  
Data Source ◽  
The Common ◽  
Extent Of Damage

Survey is one of the common data acquisition methods for data mining (Brin, Rastogi & Shim, 2003). In data mining one can rarely find a survey data set that contains complete entries of each observation for all of the variables. Commonly, surveys and questionnaires are often only partially completed by respondents. The possible reasons for incomplete data could be numerous, including negligence, deliberate avoidance for privacy, ambiguity of the survey question, and aversion. The extent of damage of missing data is unknown when it is virtually impossible to return the survey or questionnaires to the data source for completion, but is one of the most important parts of knowledge for data mining to discover. In fact, missing data is an important debatable issue in the knowledge engineering field (Tseng, Wang, & Lee, 2003).

scholarly journals A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 ◽  
Vol 155 (6) ◽  
pp. 1690-1701 ◽  
Author(s):  
L Hang ◽  
A N Theofilopoulos ◽  
F J Dixon
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Joint Inflammation ◽  
Close Correlation ◽  
Human Rheumatoid Arthritis ◽  
Igm Rheumatoid Factor ◽  
Joint Pathology ◽  
Old Females

MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.

Application of the Parallel Spatial Association Rule in Remote Sensing Data Mining

2012 ◽  
Vol 500 ◽  
pp. 598-602
Author(s):  
Jun Ma ◽  
Dong Dong Zhang
Keyword(s):  
Remote Sensing ◽  
Data Mining ◽  
Association Rule ◽  
Spatial Association ◽  
Remote Sensing Data ◽  
Inner Product ◽  
Data Mining Algorithm ◽  
Sensing Data ◽  
The Common ◽  
Frequent Item Sets

Since the remote sensing data are multi-resources and massive, the common data mining algorithm cannot effectively discover the knowledge what people want to know. However, spatial association rule can solve the problem of inefficiency in remote sensing data mining. This paper gives an algorithm to compute the frequent item sets though a method like calculating vectors inner-product. And the algorithm will introduce pruning in the whole running. It reduces the time and resources consumption effectively

scholarly journals COMPLEMENT FIXATION BY A TWO-COMPONENT ANTIBODY SYSTEM: IMMUNOGLOBULIN G AND IMMUNOGLOBULIN M ANTI-GLOBULIN (RHEUMATOID FACTOR)

1970 ◽  
Vol 132 (4) ◽  
pp. 673-693 ◽  
Author(s):  
Frank R. Schmid ◽  
Ivan M. Roitt ◽  
Maria J. Rocha
Keyword(s):  
Rheumatoid Factor ◽  
Complement Fixation ◽  
Direct Interaction ◽  
Fluid Phase ◽  
Kinetic Studies ◽  
Immunoglobulin M ◽  
Inhibitory Potency ◽  
Cell Agglutination ◽  
Igm Rheumatoid Factor ◽  
Rabbit Igg

Complement-mediated lysis of sheep erythrocytes coated with optimal concentrations of rabbit IgG hemolysin was inhibited by euglobulin fractions from the sera of patients with seropositive rheumatoid arthritis. That this was due to direct interaction with the IgG coat on the red cell rather than a nonspecific reaction with complement in the fluid phase was confirmed by controls using cells coated with IgM hemolysin. The inhibitory activity was recovered in purified IgM rheumatoid factor preparations and could be absorbed out with insoluble aggregated human IgG. The inhibitory potency of the rheumatoid factors correlated well with their sheep cell agglutination titers. Inhibition was not the result of physical aggregation of the erythrocytes by rheumatoid factor. Kinetic studies were consistent with the view that rheumatoid factor displaces C1q from its binding to IgG. Paradoxically, at suboptimal sensitizing concentrations of IgG hemolysin, rheumatoid factor enhances the fixation of complement. These results can be interpreted on the basis of the blockage of complement fixation by IgG and its replacement by a relatively weak direct fixation by the IgM rheumatoid factor. Thus, the interaction of RF with IgG generates only a limited ability to fix complement which, when contrasted with the fixation at suboptimal concentrations of IgG hemolysin alone, appears as net enhancement; when this is contrasted with fixation occurring with optimal concentrations of IgG, it appears as net inhibition.

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