Antisolvent Crystallization of the Polymorphs ofl-Histidine as a Function of Supersaturation Ratio and of Solvent Composition

2006 ◽  
Vol 6 (4) ◽  
pp. 955-963 ◽  
Author(s):  
C. P. Mark Roelands ◽  
Shanfeng Jiang ◽  
Mitsutaka Kitamura ◽  
Joop H. ter Horst ◽  
Herman J. M. Kramer ◽  
...  
Keyword(s):  
Solvent Composition ◽  
Supersaturation Ratio ◽  
Antisolvent Crystallization

Investigation of Agglomeration in the Presence of Oiling Out in the Antisolvent Crystallization Process

2021 ◽  
Author(s):  
Liping Wang ◽  
Ying Bao ◽  
Zhuang Sun ◽  
Valerie J. Pinfield ◽  
Qiuxiang Yin ◽  
...  
Keyword(s):  
Crystallization Process ◽  
Antisolvent Crystallization

scholarly journals Microwave-Assisted Extraction of Phenolics from Hibiscus sabdariffa Flowers: Method Development and Validation

Proceedings ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 51
Author(s):  
Rohmah Nur Fathimah ◽  
Widiastuti Setyaningsih ◽  
Ceferino Carrera ◽  
Miguel Palma
Keyword(s):  
Phenolic Compounds ◽  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Solvent Composition ◽  
Positive Contribution ◽  
Hibiscus Sabdariffa ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Development And Validation

Phenolics are bioactive compounds already reported in Hibiscus sabdariffa (roselle). The present study reports the development and validation of the analytical microwave-assisted extraction (MAE) method for the determination of phenolic compounds in roselle flowers to establish their positive contribution to human health. Prior to the optimization, a study for identifying phenolic compounds revealed that chlorogenic acid, protocatechuic acid, caffeic acid, and rutin were presented in Roselle. Three factors affecting MAE, viz. temperature, solvent composition, and sample to solvent ratio, were optimized employing a Box-Behnken Design (BBD) in conjunction with response surface methodology (RSM). The maximum extraction recovery was achieved using the extraction temperature of 68 °C, solvent composition of 59% MeOH in water, and 20:1 solvent to sample ratio. The kinetics experiment confirmed full recoveries (92–119%) at 15 min. Subsequently, method validation showed a satisfactory result, including low detection limits from 0.219 mg L−1 (caffeic acid) to 0.374 mg L−1 (chlorogenic acid). Both precisions and accuracy met the acceptances by AOAC. Finally, the method was successfully applied to quantify phenolics in the two most common varieties of Roselle. Chlorogenic acid was found as the main phenolic compound in both varieties

scholarly journals Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1008 ◽  
Author(s):  
Qilei Yang ◽  
Chang Zu ◽  
Wengang Li ◽  
Weiwei Wu ◽  
Yunlong Ge ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
High Performance ◽  
Water Solubility ◽  
Water Soluble ◽  
Precipitation Process ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Antisolvent Precipitation ◽  
Antisolvent Crystallization ◽  
Artificial Gastric Juice

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using 1-hexyl-3-methylimidazolium bromide (HMImBr) as solvent and water as an antisolvent. The factors influencing saturation solubility of PTX crystal powders in water in water were optimized using a single-factor design. The optimum conditions for the antisolvent precipitation process were as follows: 50 mg/mL concentration of the PTX solution, 25 °C temperature, and 1:7 solvent-to-antisolvent ratio. The PTX crystal powders were characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, high-performance liquid chromatography–mass spectrometry, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Raman spectroscopy, solid-state nuclear magnetic resonance, and dissolution and oral bioavailability studies. Results showed that the chemical structure of PTX crystal powders were unchanged; however, precipitation of the crystalline structure changed. The dissolution test showed that the dissolution rate and solubility of PTX crystal powders were nearly 3.21-folds higher compared to raw PTX in water, and 1.27 times higher in artificial gastric juice. Meanwhile, the bioavailability of PTX crystal increased 10.88 times than raw PTX. These results suggested that PTX crystal powders might have potential value to become a new oral PTX formulation with high bioavailability.

scholarly journals The effects of solvent composition on the affinity of a peptide towards hair keratin: experimental and molecular dynamics data

RSC Advances ◽  
2015 ◽  
Vol 5 (16) ◽  
pp. 12365-12371 ◽  
Author(s):  
Egipto Antunes ◽  
Célia F. Cruz ◽  
Nuno G. Azoia ◽  
Artur Cavaco-Paulo
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Solvent Composition ◽  
Hair Keratin ◽  
Dynamics Simulations ◽  
Hair Shafts ◽  
Peptide Uptake

Molecular dynamics simulations with a developed hair protofibril model demonstrated the ability to improve peptide uptake by hair shafts.

Sign in / Sign up

Export Citation Format

Share Document