Concomitant Polymorphism and Nucleation Control of DL ‐Methionine Through Antisolvent Crystallization

2021 ◽  
Author(s):  
Manivel Suresh ◽  
Karuppannan Srinivasan
Keyword(s):  
Antisolvent Crystallization

Investigation of Agglomeration in the Presence of Oiling Out in the Antisolvent Crystallization Process

2021 ◽  
Author(s):  
Liping Wang ◽  
Ying Bao ◽  
Zhuang Sun ◽  
Valerie J. Pinfield ◽  
Qiuxiang Yin ◽  
...  
Keyword(s):  
Crystallization Process ◽  
Antisolvent Crystallization

scholarly journals Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1008 ◽  
Author(s):  
Qilei Yang ◽  
Chang Zu ◽  
Wengang Li ◽  
Weiwei Wu ◽  
Yunlong Ge ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
High Performance ◽  
Water Solubility ◽  
Water Soluble ◽  
Precipitation Process ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Antisolvent Precipitation ◽  
Antisolvent Crystallization ◽  
Artificial Gastric Juice

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using 1-hexyl-3-methylimidazolium bromide (HMImBr) as solvent and water as an antisolvent. The factors influencing saturation solubility of PTX crystal powders in water in water were optimized using a single-factor design. The optimum conditions for the antisolvent precipitation process were as follows: 50 mg/mL concentration of the PTX solution, 25 °C temperature, and 1:7 solvent-to-antisolvent ratio. The PTX crystal powders were characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, high-performance liquid chromatography–mass spectrometry, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Raman spectroscopy, solid-state nuclear magnetic resonance, and dissolution and oral bioavailability studies. Results showed that the chemical structure of PTX crystal powders were unchanged; however, precipitation of the crystalline structure changed. The dissolution test showed that the dissolution rate and solubility of PTX crystal powders were nearly 3.21-folds higher compared to raw PTX in water, and 1.27 times higher in artificial gastric juice. Meanwhile, the bioavailability of PTX crystal increased 10.88 times than raw PTX. These results suggested that PTX crystal powders might have potential value to become a new oral PTX formulation with high bioavailability.

Continuous-Flow Tubular Crystallization To Discriminate between Two Competing Crystal Polymorphs. 2. Antisolvent Crystallization

2018 ◽  
Vol 18 (11) ◽  
pp. 6440-6447 ◽  
Author(s):  
Bart Rimez ◽  
Jennifer Conté ◽  
Edith Lecomte-Norrant ◽  
Patrick Cognet ◽  
Christophe Gourdon ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Antisolvent Crystallization

Study on the Solubility Characteristic of the Antisolvent Crystallization of RDX

2011 ◽  
Vol 32 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Junfang Chang ◽  
Jianlong Wang ◽  
Ying Diao ◽  
Wenyan Wang ◽  
Qihu Chen ◽  
...  
Keyword(s):  
Antisolvent Crystallization ◽  
Solubility Characteristic

Antisolvent Crystallization of the Polymorphs ofl-Histidine as a Function of Supersaturation Ratio and of Solvent Composition

2006 ◽  
Vol 6 (4) ◽  
pp. 955-963 ◽  
Author(s):  
C. P. Mark Roelands ◽  
Shanfeng Jiang ◽  
Mitsutaka Kitamura ◽  
Joop H. ter Horst ◽  
Herman J. M. Kramer ◽  
...  
Keyword(s):  
Solvent Composition ◽  
Supersaturation Ratio ◽  
Antisolvent Crystallization

Enhanced production of α-form indomethacin using the antisolvent crystallization method assisted by N2 fine bubbles

2017 ◽  
Vol 469 ◽  
pp. 91-96 ◽  
Author(s):  
Masakazu Matsumoto ◽  
Masatoshi Ohno ◽  
Yoshinari Wada ◽  
Toshiyuki Sato ◽  
Masaki Okada ◽  
...  
Keyword(s):  
Enhanced Production ◽  
Crystallization Method ◽  
Antisolvent Crystallization
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