First Study on the Effects of Interfacial Curvature and Additive Interfacial Density on Heterogeneous Nucleation. Ice Crystallization in Oil-in-Water Emulsions and Nanoemulsions with Added 1-Heptacosanol

2005 ◽  
Vol 5 (2) ◽  
pp. 451-459 ◽  
Author(s):  
Matthew J. Jamieson ◽  
Catherine E. Nicholson ◽  
Sharon J. Cooper
Keyword(s):  
Heterogeneous Nucleation ◽  
Oil In Water ◽  
Ice Crystallization

Microbeam X-ray Diffraction Analysis of Interfacial Heterogeneous Nucleation ofn-Hexadecane inside Oil-in-Water Emulsion Droplets

2008 ◽  
Vol 8 (9) ◽  
pp. 3123-3126 ◽  
Author(s):  
Yuya Shinohara ◽  
Tadashi Takamizawa ◽  
Satoru Ueno ◽  
Kiyotaka Sato ◽  
Isao Kobayashi ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
Heterogeneous Nucleation ◽  
X Ray Diffraction ◽  
Water Emulsion ◽  
X Ray ◽  
Emulsion Droplets ◽  
Oil In Water ◽  
Oil In Water Emulsion

Amorphous silica coating on α-alumina particles

1995 ◽  
Vol 53 ◽  
pp. 210-211
Author(s):  
J. W. Mellowes ◽  
C. M. Chun ◽  
I. A. Aksay
Keyword(s):  
Amorphous Silica ◽  
Heterogeneous Nucleation ◽  
Homogeneous Nucleation ◽  
Silica Coating ◽  
Full Density ◽  
Optimal Conditions ◽  
Fine Grained ◽  
Alumina Particles ◽  
Complete Mullitization ◽  
Powder Compacts

Mullite (3Al2O32SiO2) can be fabricated by transient viscous sintering using composite particles which consist of inner cores of a-alumina and outer coatings of amorphous silica. Powder compacts prepared with these particles are sintered to almost full density at relatively low temperatures (~1300°C) and converted to dense, fine-grained mullite at higher temperatures (>1500°C) by reaction between the alumina core and the silica coating. In order to achieve complete mullitization, optimal conditions for coating alumina particles with amorphous silica must be achieved. Formation of amorphous silica can occur in solution (homogeneous nucleation) or on the surface of alumina (heterogeneous nucleation) depending on the degree of supersaturation of the solvent in which the particles are immersed. Successful coating of silica on alumina occurs when heterogeneous nucleation is promoted and homogeneous nucleation is suppressed. Therefore, one key to successful coating is an understanding of the factors such as pH and concentration that control silica nucleation in aqueous solutions. In the current work, we use TEM to determine the optimal conditions of this processing.

Nanoemulsions Loaded with Amphotericin B: Development, Characterization and Leishmanicidal Activity

2019 ◽  
Vol 25 (14) ◽  
pp. 1616-1622 ◽  
Author(s):  
Gabriela Muniz Félix Araújo ◽  
Gabriela Muniz Félix Araújo ◽  
Alana Rafaela Albuquerque Barros ◽  
Alana Rafaela Albuquerque Barros ◽  
João Augusto Oshiro-Junior ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Average Diameter ◽  
Isopropyl Myristate ◽  
Neglected Diseases ◽  
Clinical Form ◽  
Hydrophobic Compounds ◽  
Internal Phase ◽  
Oil In Water ◽  
Spherical Structures ◽  
Lipid Formulations

Leishmaniasis is one of the most neglected diseases in the world. Its most severe clinical form, called visceral, if left untreated, can be fatal. Conventional therapy is based on the use of pentavalent antimonials and includes amphotericin B (AmB) as a second-choice drug. The micellar formulation of AmB, although effective, is associated with acute and chronic toxicity. Commercially-available lipid formulations emerged to overcome such drawbacks, but their high cost limits their widespread use. Drug delivery systems such as nanoemulsions (NE) have proven ability to solubilize hydrophobic compounds, improve absorption and bioavailability, increase efficacy and reduce toxicity of encapsulated drugs. NE become even more attractive because they are inexpensive and easy to prepare. The aim of this work was to incorporate AmB in NE prepared by sonicating a mixture of surfactants, Kolliphor® HS15 (KHS15) and Brij® 52, and an oil, isopropyl myristate. NE exhibited neutral pH, conductivity values consistent with oil in water systems, spherical structures with negative Zeta potential value, monomodal size distribution and average diameter of drug-containing droplets ranging from 33 to 132 nm. AmB did not modify the thermal behavior of the system, likely due to its dispersion in the internal phase. Statistically similar antileishmanial activity of AmB-loaded NE to that of AmB micellar formulation suggests further exploring them in terms of toxicity and effectiveness against amastigotes, with the aim of offering an alternative to treat visceral leishmaniasis.

Nanoemulsions- A better Approach for Anti Diabeticdrugs Delivering

2020 ◽  
Vol 17 ◽  
Author(s):  
V. Manimaran ◽  
Ponnurengam Malliappan Sivakumar ◽  
J. Narayanan ◽  
Shanmugam Parthasarathi ◽  
Pranav Kumar Prabhakar
Keyword(s):  
Aqueous Phase ◽  
Therapeutic Agent ◽  
Antidiabetic Drugs ◽  
Optical Behaviour ◽  
Antimicrobial Drugs ◽  
Drug Degradation ◽  
Oil In Water ◽  
Drug Technology ◽  
Human Use ◽  
Poor Absorption

: Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology which is very suitable for the delivery of antidiabetic drugs. In recent years the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also deliver the therapeutic agent for a longer duration. Generally, Nanoemulsions are made up of either oil-in-water or water-in-oil and size of the droplets is from fifty to thousand nanometer. Surfactants are critical substances which are added in the manufacturing of nanoemulsions. Only the surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer, diabetics. Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.

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