Microwave-Assisted Combinatorial Synthesis of Hexa-Substituted 1,4-Dihydropyridines Scaffolds Using One-Pot Two-Step Multicomponent Reaction followed by a S-Alkylation

2008 ◽  
Vol 10 (3) ◽  
pp. 436-441 ◽  
Author(s):  
Ming Li ◽  
Zhengquan Zuo ◽  
Lirong Wen ◽  
Shuwen Wang
Keyword(s):  
Multicomponent Reaction ◽  
Combinatorial Synthesis ◽  
One Pot ◽  
Microwave Assisted

scholarly journals Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach

2014 ◽  
Vol 10 ◽  
pp. 1759-1764 ◽  
Author(s):  
Barbara Palka ◽  
Angela Di Capua ◽  
Maurizio Anzini ◽  
Gyté Vilkauskaité ◽  
Algirdas Šačkus ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Cross Coupling ◽  
Terminal Alkynes ◽  
One Pot ◽  
Silver Triflate ◽  
Microwave Assisted ◽  
Spectroscopic Investigations ◽  
Coupling Conditions ◽  
Substituted 1

A straightforward synthesis of 6-substituted 1-phenyl-3-trifluoromethyl-1H-pyrazolo[4,3-c]pyridines and the corresponding 5-oxides is presented. Hence, microwave-assisted treatment of 5-chloro-1-phenyl-3-trifluoromethylpyrazole-4-carbaldehyde with various terminal alkynes in the presence of tert-butylamine under Sonogashira-type cross-coupling conditions affords the former title compounds in a one-pot multicomponent procedure. Oximes derived from (intermediate) 5-alkynyl-1-phenyl-3-trifluoromethyl-1H-pyrazole-4-carbaldehydes were transformed into the corresponding 1H-pyrazolo[4,3-c]pyridine 5-oxides by silver triflate-catalyzed cyclization. Detailed NMR spectroscopic investigations (1H, 13C, 15N and 19F) were undertaken with all obtained products.

Microwave-assisted one-pot synthesis of pyrimido［4,5-b］quinolines derivatives

2013 ◽  
Vol 30 (6) ◽  
pp. 636-642
Author(s):  
Xueli Zhang ◽  
Zhilan Lin ◽  
Huiling Hu ◽  
Jiaxin He ◽  
Yuan Gao
Keyword(s):  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis
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