Total Synthesis of (±)-Marinopyrrole A and Its Library as Potential Antibiotic and Anticancer Agents

2010 ◽  
Vol 12 (6) ◽  
pp. 900-900
Author(s):  
Chunwei Cheng ◽  
Lili Pan ◽  
Yi Chen ◽  
Hao Song ◽  
Yong Qin* ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

Applications of Total Synthesis Toward the Discovery of Clinically Useful Anticancer Agents

ChemInform ◽  
2007 ◽  
Vol 38 (44) ◽  
Author(s):  
Rebecca M. Wilson ◽  
Samuel J. Danishefsky
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

scholarly journals Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents

2020 ◽  
Vol 56 (10) ◽  
pp. 1529-1532
Author(s):  
Talia R. Pettigrew ◽  
Rachel J. Porter ◽  
Stephen J. Walsh ◽  
Michael P. Housden ◽  
Nelson Y. S. Lam ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Sar Studies ◽  
Synthesis And Biological Evaluation

Analysis of bound structures and SAR studies led to the function-oriented simplification of the aplyronines; a convergent and modular synthetic platform then enabled the total synthesis and biological evaluation of four novel analogues.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

2010 ◽  
Vol 46 (2) ◽  
pp. 261-263 ◽  
Author(s):  
Ian Paterson ◽  
Guy J. Naylor ◽  
Takeshi Fujita ◽  
Esther Guzmán ◽  
Amy E. Wright
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

The Total Synthesis of an Aurone Isolated from Uvaria hamiltonii: Aurones and Flavones as Anticancer Agents.

ChemInform ◽  
2004 ◽  
Vol 35 (8) ◽  
Author(s):  
Nicholas J. Lawrence ◽  
David Rennison ◽  
Alan T. McGown ◽  
John A. Hadfield
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents

2009 ◽  
Vol 81 (2) ◽  
pp. 169-180 ◽  
Author(s):  
Ian Paterson ◽  
Nicola M. Gardner ◽  
Guy J. Naylor
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Human Cancer Cell Lines ◽  
Synthetic Strategy ◽  
Sar Studies ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Microtubule Stabilizing Agent

Structural modification of the dictyostatin macrolide template through adaptation of our total synthesis has led to the identification of a number of potent analogs of this novel microtubule-stabilizing agent. A common synthetic strategy was exploited, employing a (Z)-selective Still-Gennari olefination between various advanced C11-C26 aldehyde and C4-C10 (or C1-C10) β-ketophosphonate intermediates. In vitro evaluation of the growth inhibitory activity of these analogs against both Taxol-sensitive and -resistant human cancer cell lines has provided a foundation for structure-activity relationship (SAR) studies to help define the pharmacophore region.

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