Applications of Total Synthesis Toward the Discovery of Clinically Useful Anticancer Agents

ChemInform ◽  
2007 ◽  
Vol 38 (44) ◽  
Author(s):  
Rebecca M. Wilson ◽  
Samuel J. Danishefsky
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

scholarly journals Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents

2020 ◽  
Vol 56 (10) ◽  
pp. 1529-1532
Author(s):  
Talia R. Pettigrew ◽  
Rachel J. Porter ◽  
Stephen J. Walsh ◽  
Michael P. Housden ◽  
Nelson Y. S. Lam ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Sar Studies ◽  
Synthesis And Biological Evaluation

Analysis of bound structures and SAR studies led to the function-oriented simplification of the aplyronines; a convergent and modular synthetic platform then enabled the total synthesis and biological evaluation of four novel analogues.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

2010 ◽  
Vol 46 (2) ◽  
pp. 261-263 ◽  
Author(s):  
Ian Paterson ◽  
Guy J. Naylor ◽  
Takeshi Fujita ◽  
Esther Guzmán ◽  
Amy E. Wright
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

The Total Synthesis of an Aurone Isolated from Uvaria hamiltonii: Aurones and Flavones as Anticancer Agents.

ChemInform ◽  
2004 ◽  
Vol 35 (8) ◽  
Author(s):  
Nicholas J. Lawrence ◽  
David Rennison ◽  
Alan T. McGown ◽  
John A. Hadfield
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents

Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents

2009 ◽  
Vol 81 (2) ◽  
pp. 169-180 ◽  
Author(s):  
Ian Paterson ◽  
Nicola M. Gardner ◽  
Guy J. Naylor
Keyword(s):  
Total Synthesis ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Human Cancer Cell Lines ◽  
Synthetic Strategy ◽  
Sar Studies ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Microtubule Stabilizing Agent

Structural modification of the dictyostatin macrolide template through adaptation of our total synthesis has led to the identification of a number of potent analogs of this novel microtubule-stabilizing agent. A common synthetic strategy was exploited, employing a (Z)-selective Still-Gennari olefination between various advanced C11-C26 aldehyde and C4-C10 (or C1-C10) β-ketophosphonate intermediates. In vitro evaluation of the growth inhibitory activity of these analogs against both Taxol-sensitive and -resistant human cancer cell lines has provided a foundation for structure-activity relationship (SAR) studies to help define the pharmacophore region.

scholarly journals Enantioselective Total Synthesis of Otteliones A and B, Novel and Powerful Antitumor Agents from the Freshwater Plant Ottelia alismoides

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800
Author(s):  
Tadashi Katoh
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Agents ◽  
Antitumor Agents ◽  
Formal Synthesis ◽  
Total Syntheses ◽  
Enantioselective Total Synthesis ◽  
Significant Attention

Otteliones A and B isolated from the freshwater plant Ottelia alismoides have attracted significant attention because of their potential as novel anticancer agents. In this review four independent enantioselective total syntheses and one formal synthesis of these natural products are presented with particular focus on their methodology and strategy.

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