α-Keto Amide Peptides:  A Synthetic Strategy to Resin-Bound Peptide Isosteres for Protease Inhibitor Screening on Solid Support

2004 ◽  
Vol 6 (2) ◽  
pp. 181-195 ◽  
Author(s):  
Alexandra Papanikos ◽  
Morten Meldal
Keyword(s):  
Protease Inhibitor ◽  
Solid Support ◽  
Inhibitor Screening ◽  
Synthetic Strategy ◽  
Peptide Isosteres

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro

Biochimie ◽  
2014 ◽  
Vol 103 ◽  
pp. 137-143 ◽  
Author(s):  
Ewa Burchacka ◽  
Marcin Sieńczyk ◽  
Inga-Maria Frick ◽  
Magdalena Wysocka ◽  
Adam Lesner ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Human Fibrinogen ◽  
Inhibitor Screening ◽  
Bacteria Growth

A Different Approach to the EGFR Inhibitor Gefitinib Involving Solid-Phase Synthesis

Synlett ◽  
2018 ◽  
Vol 29 (10) ◽  
pp. 1346-1350 ◽  
Author(s):  
Luísa Carvalho ◽  
André Sequeira ◽  
Ana Lourenço ◽  
Luísa Ferreira ◽  
Paula Branco ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
Egfr Inhibitor ◽  
Phase Synthesis ◽  
Synthetic Strategy ◽  
Colorimetric Assays ◽  
First Time ◽  
Synthesis Approach

An efficient solid-phase synthesis approach is here reported for the first time to prepare the EGFR inhibitor Gefitinib. The five-step synthetic strategy used FMP resin as the solid support, and FTIR and colorimetric assays were used to track the reaction’s progress. Gefitinib was obtained with an overall yield of 40%.

Bioavailability of the HCV NS3/4A Protease Inhibitor Telaprevir–Effect of Different Types of Food

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
R van Heeswijk ◽  
G Boogaerts ◽  
E De Paepe ◽  
T Vangeneugden ◽  
K De Backer
Keyword(s):  
Protease Inhibitor ◽  
Different Types ◽  
Protease Inhibitor Telaprevir
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