scholarly journals Extreme Entropy–Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease

2012 ◽  
Vol 7 (9) ◽  
pp. 1536-1546 ◽  
Author(s):  
Nancy M. King ◽  
Moses Prabu-Jeyabalan ◽  
Rajintha M. Bandaranayake ◽  
Madhavi N. L. Nalam ◽  
Ellen A. Nalivaika ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Resistant Variant ◽  
Hiv 1 ◽  
Drug Resistant Variant

scholarly journals Backbone 1H, 13C, and 15N chemical shift assignment for HIV-1 protease subtypes and multi-drug resistant variant MDR 769

2012 ◽  
Vol 7 (2) ◽  
pp. 199-202 ◽  
Author(s):  
Xi Huang ◽  
Ian Mitchelle S. de Vera ◽  
Angelo M. Veloro ◽  
James R. Rocca ◽  
Carlos Simmerling ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Chemical Shift Assignment ◽  
Drug Resistant ◽  
Resistant Variant ◽  
Shift Assignment ◽  
Hiv 1 ◽  
Drug Resistant Variant

scholarly journals Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency

Biochemistry ◽  
2015 ◽  
Vol 54 (2) ◽  
pp. 422-433 ◽  
Author(s):  
Nathan E. Goldfarb ◽  
Meray Ohanessian ◽  
Shyamasri Biswas ◽  
T. Dwight McGee ◽  
Brian P. Mahon ◽  
...  
Keyword(s):  
Active Site ◽  
Drug Resistant ◽  
Resistant Variant ◽  
Sliding Mechanism ◽  
Hiv 1 ◽  
Drug Resistant Variant

scholarly journals The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

Biochemistry ◽  
2017 ◽  
Vol 56 (27) ◽  
pp. 3443-3453 ◽  
Author(s):  
Meha P. Patel ◽  
Liya Hu ◽  
Vlatko Stojanoski ◽  
Banumathi Sankaran ◽  
B. V. Venkataram Prasad ◽  
...  
Keyword(s):  
Active Site ◽  
Drug Resistant ◽  
Resistant Variant ◽  
Cephalosporin Antibiotics ◽  
Drug Resistant Variant

scholarly journals Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant

2018 ◽  
Vol 61 (14) ◽  
pp. 6379-6397 ◽  
Author(s):  
Jian Zhang ◽  
Vasanthanathan Poongavanam ◽  
Dongwei Kang ◽  
Chiara Bertagnin ◽  
Huamei Lu ◽  
...  
Keyword(s):  
Influenza A ◽  
Drug Resistant ◽  
Resistant Variant ◽  
Drug Resistant Variant ◽  
Group 1

Meta-Analysis and Time Series Modeling Allow a Systematic Review of Primary HIV-1 Drug-Resistant Prevalence in Latin America and Caribbean

2015 ◽  
Vol 13 (2) ◽  
pp. 125-142 ◽  
Author(s):  
Antonio Coelho ◽  
Ronald Moura ◽  
Ronaldo Silva ◽  
Anselmo Kamada ◽  
Rafael Guimaraes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Time Series ◽  
Latin America ◽  
Meta Analysis ◽  
Drug Resistant ◽  
Time Series Modeling ◽  
Latin America And Caribbean ◽  
Hiv 1

scholarly journals Factors Influencing HIV Drug Resistance among Pregnant Women in Luanda, Angola: Findings from a Cross-Sectional Study

2021 ◽  
Vol 6 (1) ◽  
pp. 29
Author(s):  
Cruz S. Sebastião ◽  
Joana Morais ◽  
Miguel Brito
Keyword(s):  
Drug Resistance ◽  
Pregnant Women ◽  
Rural Areas ◽  
Cross Sectional Study ◽  
Drug Resistant ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hiv Drug Resistance ◽  
Hiv 1 ◽  
High Educational

The increase in HIV infection and drug-resistant strains is an important public health concern, especially in resource-limited settings. However, the identification of factors related to the propagation of infectious diseases represents a crucial target offering an opportunity to reduce health care costs as well as deepening the focus on preventing infection in high-risk groups. In this study, we investigate the factors related to drug resistance among HIV-infected pregnant women in Luanda, the capital city of Angola. This was a part of a cross-sectional study conducted with 42 HIV-positive pregnant women. A blood sample was collected, and HIV-1 genotyping was carried out using an in-house method. Multivariate analyses were performed to determine the interaction between sociodemographic characteristics and drug resistance. HIV drug resistance was detected in 44.1% of the studied population. High probabilities of drug resistance were observed for HIV-infected pregnant women living in rural areas (AOR: 2.73; 95% CI: 0.50–14.9) with high educational level (AOR: 6.27; 95% CI: 0.77–51.2) and comorbidities (AOR: 5.47; 95% CI: 0.28–106) and infected with a HIV-1 non-B subtype other than subtype C (AOR: 1.60; 95% CI: 0.25–10.3). The present study reports high HIV drug resistance. Furthermore, older-age, rural areas, high educational levels, unemployed status, having comorbidities, and HIV-1 subtypes were factors related to drug resistance. These factors impact on drug susceptibility and need to be urgently addressed in order to promote health education campaigns able to prevent the spread of drug-resistant HIV strains in Angola.

scholarly journals Cellular Immune Response Induced by DNA Immunization of Mice with Drug Resistant Integrases of HIV-1 Clade A Offers Partial Protection against Growth and Metastatic Activity of Integrase-Expressing Adenocarcinoma Cells

2021 ◽  
Vol 9 (6) ◽  
pp. 1219
Author(s):  
Maria Isaguliants ◽  
Olga Krotova ◽  
Stefan Petkov ◽  
Juris Jansons ◽  
Ekaterina Bayurova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
T Cell ◽  
Cell Response ◽  
Mammalian Cells ◽  
Metastatic Potential ◽  
T Cell Response ◽  
Dna Immunization ◽  
Drug Resistant ◽  
Metastatic Activity ◽  
Hiv 1

Therapeutic DNA-vaccination against drug-resistant HIV-1 may hinder emergence and spread of drug-resistant HIV-1, allowing for longer successful antiretroviral treatment (ART) up-to relief of ART. We designed DNA-vaccines against drug-resistant HIV-1 based on consensus clade A integrase (IN) resistant to raltegravir: IN_in_r1 (L74M/E92Q/V151I/N155H/G163R) or IN_in_r2 (E138K/G140S/Q148K) carrying D64V abrogating IN activity. INs, overexpressed in mammalian cells from synthetic genes, were assessed for stability, route of proteolytic degradation, and ability to induce oxidative stress. Both were found safe in immunotoxicity tests in mice, with no inherent carcinogenicity: their expression did not enhance tumorigenic or metastatic potential of adenocarcinoma 4T1 cells. DNA-immunization of mice with INs induced potent multicytokine T-cell response mainly against aa 209–239, and moderate IgG response cross-recognizing diverse IN variants. DNA-immunization with IN_in_r1 protected 60% of mice from challenge with 4Tlluc2 cells expressing non-mutated IN, while DNA-immunization with IN_in_r2 protected only 20% of mice, although tumor cells expressed IN matching the immunogen. Tumor size inversely correlated with IN-specific IFN-γ/IL-2 T-cell response. IN-expressing tumors displayed compromised metastatic activity restricted to lungs with reduced metastases size. Protective potential of IN immunogens relied on their immunogenicity for CD8+ T-cells, dependent on proteasomal processing and low level of oxidative stress.

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