Enhancing Effect of Low Culture Temperature on Specific Antibody Productivity of Recombinant Chinese Hamster Ovary Cells: Clonal Variation

2004 ◽  
Vol 20 (6) ◽  
pp. 1683-1688 ◽  
Author(s):  
S.K. Yoon ◽  
S.O. Hwang ◽  
G.M. Lee
Keyword(s):  
Specific Antibody ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Clonal Variation ◽  
Culture Temperature ◽  
Ovary Cells ◽  
Enhancing Effect ◽  
Antibody Productivity ◽  
Low Culture

Effect of culture temperature on TNFR-Fc productivity in recombinant glutamine synthetase-chinese hamster ovary cells

2010 ◽  
Vol 32 (9) ◽  
pp. 1239-1244 ◽  
Author(s):  
Li Fan ◽  
Liang Zhao ◽  
Zhaoyang Ye ◽  
Yating Sun ◽  
Tianci Kou ◽  
...  
Keyword(s):  
Glutamine Synthetase ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Culture Temperature ◽  
Ovary Cells

scholarly journals Biological insights into the expression of translation initiation factors from recombinant CHOK1SV cell lines and their relationship to enhanced productivity

2015 ◽  
Vol 472 (3) ◽  
pp. 261-273 ◽  
Author(s):  
Emma J. Mead ◽  
Rosalyn J. Masterton ◽  
Marc Feary ◽  
Olga Obrezanova ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Chinese Hamster Ovary ◽  
Closed Loop ◽  
Chinese Hamster Ovary Cells ◽  
Recombinant Antibody ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Initiation Factors ◽  
Translation Initiation Factors ◽  
Antibody Productivity

We show for translation initiation factors involved in formation of the closed loop mRNA, their expression is associated with recombinant antibody productivity in Chinese hamster ovary cells and maintaining these is important in determining the cells capacity for antibody productivity.

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