Assessment of the Two Helicobacter pylori α-1,3-Fucosyltransferase Ortholog Genes for the Large-Scale Synthesis of LewisX Human Milk Oligosaccharides by Metabolically Engineered Escherichia coli

2008 ◽  
Vol 20 (2) ◽  
pp. 412-419 ◽  
Author(s):  
Claire Dumon ◽  
Eric Samain ◽  
Bernard Priem
Keyword(s):  
Escherichia Coli ◽  
Helicobacter Pylori ◽  
Human Milk ◽  
Large Scale ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Engineered Escherichia Coli ◽  
Large Scale Synthesis ◽  
Metabolically Engineered Escherichia Coli

scholarly journals Human Milk Oligosaccharides Inhibit the Adhesion to Caco-2 Cells of Diarrheal Pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris

2006 ◽  
Vol 59 (3) ◽  
pp. 377-382 ◽  
Author(s):  
Giovanni V Coppa ◽  
Lucia Zampini ◽  
Tiziana Galeazzi ◽  
Bruna Facinelli ◽  
Luigi Ferrante ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Human Milk ◽  
Vibrio Cholerae ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides

scholarly journals Do Human Milk Oligosaccharides Protect Against Infant Atopic Disorders and Food Allergy?

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3212
Author(s):  
Soo Min Han ◽  
Aristea Binia ◽  
Keith M. Godfrey ◽  
Sarah El-Heis ◽  
Wayne S. Cutfield
Keyword(s):  
Food Allergy ◽  
Immune System ◽  
Human Milk ◽  
Large Scale ◽  
Current Data ◽  
Lactation Period ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Microbiome Composition ◽  
The Impact

Atopic disorders (AD), often coexistent with food allergy (FA), start developing in early life and have lifelong health consequences. Breastfeeding is thought to be protective against AD and FA, but the data are controversial, and mechanisms are not well understood. Human milk oligosaccharides (HMOs) are complex carbohydrates that are abundant in human milk. These are thought to contribute to the development of the infant immune system by (i) promoting healthy microbiome, (ii) inhibiting pathogen binding to gut mucosa and (iii) modulating the immune system. Differences in microbiome composition between allergic and healthy infants have been observed, regardless of breastfeeding history. To date, limited studies have examined the preventive effects of HMOs on AD and FA in infants and current data relies on observation studies as trials of varying HMO intake through randomising individuals to breastfeeding are unethical. There is evidence for beneficial effects of breastfeeding on lowering the risks of FA, eczema and asthma but there are inconsistencies amongst studies in the duration of breastfeeding, diagnostic criteria for AD and the age at which the outcome was assessed. Furthermore, current analytical methods primarily used today only allow detection of 16–20 major HMOs while more than 100 types have been identified. More large-scale longitudinal studies are required to investigate the role of HMO composition and the impact of changes over the lactation period in preventing AD and FA later in life.

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