Improving the Industrial Production of 6-APA: Enzymatic Hydrolysis of Penicillin G in the Presence of Organic Solvents

2003 ◽  
Vol 19 (6) ◽  
pp. 1639-1642 ◽  
Author(s):  
O. Abian ◽  
C. Mateo ◽  
G. Fernandez-Lorente ◽  
J.M. Guisan ◽  
R. Fernandez-Lafuente
Keyword(s):  
Enzymatic Hydrolysis ◽  
Organic Solvents ◽  
Industrial Production ◽  
Penicillin G ◽  
Hydrolysis Of

Enzymatic hydrolysis of penicillin G in ionic liquids

2008 ◽  
Vol 136 ◽  
pp. S391
Author(s):  
Mai Ngoc Lan ◽  
Sung Ho Ha ◽  
Yoon-Mo Koo
Keyword(s):  
Ionic Liquids ◽  
Enzymatic Hydrolysis ◽  
Penicillin G ◽  
Hydrolysis Of

Extraction and enzymatic hydrolysis of Penicillin G in emulsion liquid membranes

1996 ◽  
Vol 208 (1) ◽  
pp. 133-144 ◽  
Author(s):  
I. Miesiąc ◽  
K. Schügerl ◽  
A. Hasler ◽  
J. Szymanowski
Keyword(s):  
Enzymatic Hydrolysis ◽  
Penicillin G ◽  
Liquid Membranes ◽  
Emulsion Liquid Membranes ◽  
Hydrolysis Of

Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization

2002 ◽  
Vol 78 (4) ◽  
pp. 395-402 ◽  
Author(s):  
M. B. Diender ◽  
A. J. J. Straathof ◽  
T. van der Does ◽  
C. Ras ◽  
J. J. Heijnen
Keyword(s):  
Enzymatic Hydrolysis ◽  
Penicillin G ◽  
Equilibrium Modeling ◽  
Hydrolysis Of

scholarly journals Fractionation of the mixture obtained by the enzymatic hydrolysis of penicillin G

2002 ◽  
Vol 56 (9) ◽  
pp. 386-391 ◽  
Author(s):  
Dan Cascaval ◽  
Corneliu Oniscu ◽  
Anca-Irina Galaction
Keyword(s):  
Enzymatic Hydrolysis ◽  
Ph Value ◽  
Molar Concentration ◽  
Reactive Extraction ◽  
Penicillin G ◽  
Flow Sheet ◽  
Extraction Degree ◽  
Process Flow Sheet ◽  
The Individual ◽  
Hydrolysis Of

Using the experimental data on the individual physical and reactive extraction of 6APA with 1,2-dichlororethane, D2EHPA and Amberlite LA-2 together with data on the influence of the pH value of the aqueous phase and the Amberlite LA-2 concentration on the selective separation of 6APA, PG and PAA from a mixture, a process flow sheet for the fractionation of the solution obtained by the enzymatic hydrolysis of PG has been elaborated and applied. Thus, at pH=10, 6APA was selectively separated by four extraction stages, the overall extraction degree being 98.8%. PG was selectively extracted from the raffinate at pH=6 by three extraction stages, adjusting the molar concentration of Amberlite LA-2 to the value of the PG molar concentration for each extraction stage. The antibiotic extraction degree was 99.6%.

scholarly journals Hydrogel coated monoliths for enzymatic hydrolysis of penicillin G

2008 ◽  
Vol 35 (8) ◽  
pp. 815-824 ◽  
Author(s):  
K. M. de Lathouder ◽  
M. W. Smeltink ◽  
A. J. J. Straathof ◽  
M. A. Paasman ◽  
E. J. A. X. van de Sandt ◽  
...  
Keyword(s):  
Enzymatic Hydrolysis ◽  
Penicillin G ◽  
Hydrolysis Of
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