Arabinogalactan−Folic Acid−Drug Conjugate for Targeted Delivery and Target-Activated Release of Anticancer Drugs to Folate Receptor-Overexpressing Cells

2010 ◽  
Vol 11 (1) ◽  
pp. 294-303 ◽  
Author(s):  
Roy I. Pinhassi ◽  
Yehuda G. Assaraf ◽  
Shimon Farber ◽  
Michal Stark ◽  
Diana Ickowicz ◽  
...  
Keyword(s):  
Folic Acid ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Folate Receptor ◽  
Drug Conjugate

Synthesis and Characterization of Folic Acid Conjugated Gemcitabine Tethered Silver Nanoparticles (FA-GEM-AgNPs) for Targeted Delivery

2020 ◽  
Vol 26 (26) ◽  
pp. 3141-3146 ◽  
Author(s):  
Arjunan Karuppaiah ◽  
Ravikumar Rajan ◽  
Sivaram Hariharan ◽  
Dinesh K. Balasubramaniam ◽  
Marslin Gregory ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silver Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Cytotoxic Effect ◽  
Apoptotic Cell ◽  
Folate Receptor ◽  
Cancer Cell Line ◽  
One Pot

Background: Silver nanoparticles (AgNPs) have attracted considerable interest in the medical industry due to their physicochemical properties, small size, and surface plasmon behavior. Their smaller particle size and instability in blood circulation leads to toxicity due to its aggregation as Ag+ ions and accumulation at the deepseated organ. In the present study, we aimed at reducing the toxicity of AgNPs by conjugation with an anticancer drug GEM and to improve their internalization through folate receptors-mediated endocytosis by capping the nanoparticles with folic acid (FA). Methods: One-pot facile synthesis of FA capped silver nanoparticles (FA-AgNPs) has been achieved by using FA as a reducing agent. FA-AgNPs were mixed with Gemcitabine (GEM) to obtain tethered FA-GEM-AgNPs. Nanoparticles were characterized by Dynamic Light Scattering (DLS), UV-Visible spectroscopy, Transmission Electron Microscopy (TEM), Energy Dispersive X-ray Analysis (EDAX), Selected Area Electron Diffraction (SAED), and Atomic Absorption Spectroscopy (AAS). The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was carried out to determine the cytotoxic effect of the prepared nanoformulations. The apoptotic cell death induced by FA-GEM-AgNPs in breast cancer cells were monitored with Acridine orange (AO)/Ethidium Bromide (EtBr) staining. Conclusion: Compared to GEM and AgNPs, FA-GEM-AgNPs showed enhanced cytotoxic effect and internalization in MDA-MB-453 breast cancer cell line. FA-GEM-AgNPs could be an ideal candidate for targeting cancer cells via folate receptor-mediated endocytosis.

scholarly journals Folate receptor targeted delivery of paclitaxel to breast cancer cells via folic acid conjugated graphene oxide grafted methyl acrylate nanocarrier

2019 ◽  
Vol 110 ◽  
pp. 906-917 ◽  
Author(s):  
Kandasamy Vinothini ◽  
Naresh Kumar Rajendran ◽  
Andy Ramu ◽  
Nandhakumar Elumalai ◽  
Mariappan Rajan
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Cancer Cells ◽  
Methyl Acrylate ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Folate Receptor

scholarly journals In Situ Synthesis of Fluorescent Mesoporous Silica–Carbon Dot Nanohybrids Featuring Folate Receptor-Overexpressing Cancer Cell Targeting and Drug Delivery

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuai Zhao ◽  
Shan Sun ◽  
Kai Jiang ◽  
Yuhui Wang ◽  
Yu Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Targeted Delivery ◽  
Folate Receptor ◽  
Mesoporous Silica Nanoparticles ◽  
Yellow Emission ◽  
Solvothermal Reaction ◽  
Carbon Dot

Abstract Multifunctional nanocarrier-based theranostics is supposed to overcome some key problems in cancer treatment. In this work, a novel method for the preparation of a fluorescent mesoporous silica–carbon dot nanohybrid was developed. Carbon dots (CDs), from folic acid as the raw material, were prepared in situ and anchored on the surface of amino-modified mesoporous silica nanoparticles (MSNs–NH2) via a microwave-assisted solvothermal reaction. The as-prepared nanohybrid (designated MSNs–CDs) not only exhibited strong and stable yellow emission but also preserved the unique features of MSNs (e.g., mesoporous structure, large specific surface area, and good biocompatibility), demonstrating a potential capability for fluorescence imaging-guided drug delivery. More interestingly, the MSNs–CDs nanohybrid was able to selectively target folate receptor-overexpressing cancer cells (e.g., HeLa), indicating that folic acid still retained its function even after undergoing the solvothermal reaction. Benefited by these excellent properties, the fluorescent MSNs–CDs nanohybrid can be employed as a fluorescence-guided nanocarrier for the targeted delivery of anticancer drugs (e.g., doxorubicin), thereby enhancing chemotherapeutic efficacy and reducing side effects. Our studies may provide a facile strategy for the fabrication of multifunctional MSN-based theranostic platforms, which is beneficial in the diagnosis and therapy of cancers in future.

scholarly journals Folic Acid-Functionalized, Condensed Magnetic Nanoparticles for Targeted Delivery of Doxorubicin to Tumor Cancer Cells Overexpressing the Folate Receptor

ACS Omega ◽  
2019 ◽  
Vol 4 (26) ◽  
pp. 22214-22227 ◽  
Author(s):  
Athina Angelopoulou ◽  
Argiris Kolokithas-Ntoukas ◽  
Christos Fytas ◽  
Konstantinos Avgoustakis
Keyword(s):  
Folic Acid ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Folate Receptor

Development of a Cleavable Biotin‐Drug Conjugate Hydrogelator for the Controlled and Dual Delivery of Anticancer Drugs

2021 ◽  
Vol 6 (13) ◽  
pp. 3256-3261
Author(s):  
Soumi Das ◽  
Krishan Kumar Thakur ◽  
Ajaikumar B. Kunnumakkara ◽  
Lal Mohan Kundu
Keyword(s):  
Anticancer Drugs ◽  
Drug Conjugate
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