Development of a Cleavable Biotin‐Drug Conjugate Hydrogelator for the Controlled and Dual Delivery of Anticancer Drugs

2021 ◽  
Vol 6 (13) ◽  
pp. 3256-3261
Author(s):  
Soumi Das ◽  
Krishan Kumar Thakur ◽  
Ajaikumar B. Kunnumakkara ◽  
Lal Mohan Kundu
Keyword(s):  
Anticancer Drugs ◽  
Drug Conjugate

Arabinogalactan−Folic Acid−Drug Conjugate for Targeted Delivery and Target-Activated Release of Anticancer Drugs to Folate Receptor-Overexpressing Cells

2010 ◽  
Vol 11 (1) ◽  
pp. 294-303 ◽  
Author(s):  
Roy I. Pinhassi ◽  
Yehuda G. Assaraf ◽  
Shimon Farber ◽  
Michal Stark ◽  
Diana Ickowicz ◽  
...  
Keyword(s):  
Folic Acid ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Folate Receptor ◽  
Drug Conjugate

Erythrocytes and the transfer of anticancer drugs and metabolites: A possible relationship with therapeutic outcome

2001 ◽  
Vol 28 (2F) ◽  
pp. 24-28 ◽  
Author(s):  
Herlinde Dumez ◽  
Martin Highley ◽  
Gunther Guetens ◽  
Gert De Boeck ◽  
Axel Hanauske ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Therapeutic Outcome ◽  
Drugs And Metabolites

Cytotoxic Effect of the Combination of Gemcitabine and Atorvastatin Loaded in Microemulsion on the HCT116 Colon Cancer Cells

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Mayson H. Alkhatib ◽  
Dalal Al-Saedi ◽  
Wadiah S. Backer
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
In Vitro Study ◽  
Colon Cancer Cells ◽  
Apoptosis Detection ◽  
Hct116 Cells

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

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