Covalent Grafting of Poly(l-lactide) to Tune the In Vitro Degradation Rate

2007 ◽  
Vol 8 (8) ◽  
pp. 2492-2496 ◽  
Author(s):  
Martina Källrot ◽  
Ulrica Edlund ◽  
Ann-Christine Albertsson
Keyword(s):  
Degradation Rate ◽  
In Vitro Degradation ◽  
Covalent Grafting

Photo-Crosslinkable Double-Network Hyaluronic Acid Based Hydrogel Dressing

2020 ◽  
Vol 982 ◽  
pp. 59-66
Author(s):  
Yu Long Ding ◽  
Hong Bo Zhang ◽  
Rui Xue Yin ◽  
Wen Jun Zhang
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Degradation Rate ◽  
In Vitro Degradation ◽  
Double Network ◽  
Biological Potential ◽  
Human Dermis ◽  
Enzymatic Degradability ◽  
Hdf Cells

Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility and enzymatic degradability. In this paper a photo-crosslinking double-network hyaluronic acid-based hydrogel dressing was proposed. Hyaluronic acid can be UV-crosslinked by modification with methacrylic anhydride (HA-MA) and disulfide-crosslinked by modification with 3,3'-dithiobis (propionylhydrazide) (DTP) (HA-SH). The mixings of these two materials at different ratios were produced. All the samples can be quickly gelled at 365 nm for 10 s. The rheological tests show that the storage modulus (G') of the double network (HA-SH/HA-MA) hydrogel is increased with the increase of HA-SH content. The HA-SH/HA-MA hydrogel has porous structure, high swelling ratio and Controlled degradation rate. In vitro degradation tests show that the ratio of HA-SH/HA-MA ratio was 9:1 (S9M1) in 100 U/ml hyaluronidase (Hase) degraded by 89.91±2.26% at 11d. The cytocompatibility of HA-SH/HA-MA hydrogels was proved by Live/Dead stainings and CCK-8 assays in the human dermis fibroblasts (HDF) cells test. All these results highlight the biological potential of the HA-SH/HA-MA hydrogels for DFU intervention.

scholarly journals Tannin concentration and degradation rate in vitro of Morus alba and Hibiscus rosa-sinensis

2019 ◽  
Vol 29 ◽  
pp. 1-6
Author(s):  
Aldenamar Cruz Hernández ◽  
David Hernández Sanchez ◽  
Armando Gómez-Vázquez ◽  
Alejandra Govea-Luciano ◽  
Juan M. Pinos-Rodríguez ◽  
...  
Keyword(s):  
Condensed Tannins ◽  
Crude Protein ◽  
Degradation Rate ◽  
Condensed Tannin ◽  
Morus Alba ◽  
Neutral Detergent Fiber ◽  
In Vitro Degradation ◽  
Hibiscus Rosa Sinensis ◽  
Tannin Concentration

The study evaluated the influence of age (30, 60, 90 and 120 days) on dry matter (DM), crude protein (CP), neutral detergent fiber (NDF), free condensed tannins (FCT), fiber-bound condensed tannins (FBCT), protein-bound condensed tannin content (PBCT), in vitro degradation rate of DM (DMkd), CP (CPkd) and NDF (NDFkd) of Morus alba (MA) and Hibiscus rosa-sinensis (HRS). For MA leaves, there was a quadratic (p < 0.01) relationship between CP content and age: the CP content of 60, 90 and 120 days-old leaves was similar, but it was lower than that of 30 days-old leaves. For HRS leaves, CP content decreased linearly (p < 0.01) as age increased, and NDF content increased linearly (p < 0.01). For both MA and HRS, there were cubit (p < 0.01) effects of age on FCT, FBCT and PBCT content, in which the highest values were found in 120-d-old leaves and the lowest in 30 and 90 d-old leaves. Furthermore, old leaves had a linear decrease in DMkd, CPkd, and NDFkd. DMkd, CPkd, and NDFkd negatively correlated (p < 0.001) with FCT, FBCT, and PBCT content. For both MA and HRS, 90 days-old leaves had higher nutritional value than 120 days-old leaves.

In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres

2011 ◽  
Vol 7 (9) ◽  
pp. 3459-3468 ◽  
Author(s):  
R.P. Félix Lanao ◽  
S.C.G. Leeuwenburgh ◽  
J.G.C. Wolke ◽  
J.A. Jansen
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Degradation Rate ◽  
Plga Microspheres ◽  
In Vitro Degradation

scholarly journals Biocompatibility and Degradation Behavior of Molybdenum in an In Vivo Rat Model

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7776
Author(s):  
Antje Schauer ◽  
Christian Redlich ◽  
Jakob Scheibler ◽  
Georg Poehle ◽  
Peggy Barthel ◽  
...  
Keyword(s):  
Vessel Wall ◽  
Degradation Rate ◽  
Degradation Behavior ◽  
C Reactive Protein ◽  
In Vitro Degradation ◽  
Reactive Protein ◽  
Degradation Rates ◽  
In Vivo Degradation

The biocompatibility and degradation behavior of pure molybdenum (Mo) as a bioresorbable metallic material (BMM) for implant applications were investigated. In vitro degradation of a commercially available Mo wire (ø250 µm) was examined after immersion in modified Kokubo’s SBF for 28 days at 37 °C and pH 7.4. For assessment of in vivo degradation, the Mo wire was implanted into the abdominal aorta of female Wistar rats for 3, 6 and 12 months. Microstructure and corrosion behavior were analyzed by means of SEM/EDX analysis. After explantation, Mo levels in serum, urine, aortic vessel wall and organs were investigated via ICP-OES analysis. Furthermore, histological analyses of the liver, kidneys, spleen, brain and lungs were performed, as well as blood count and differentiation by FACS analysis. Levels of the C-reactive protein were measured in blood plasma of all the animals. In vitro and in vivo degradation behavior was very similar, with formation of uniform, non-passivating and dissolving product layers without occurrence of a localized corrosion attack. The in vitro degradation rate was 101.6 µg/(cm2·d) which corresponds to 33.6 µm/y after 28 days. The in vivo degradation rates of 12, 33 and 36 µg/(cm2·d) were observed after 3, 6 and 12 months for the samples properly implanted in the aortic vessel wall. This corresponds with a degradation rate of 13.5 µm/y for the 12-month cohort. However, the magnitude of degradation strongly depended on the implant site, with the wires incorporated into the vessel wall showing the most severe degradation. Degradation of the implanted Mo wire neither induced an increase in serum or urine Mo levels nor were elevated Mo levels found in the liver and kidneys compared with the respective controls. Only in the direct vicinity of the implant in the aortic vessel wall, a significant amount of Mo was found, which, however, was far below the amounts to be expected from degrading wires. No abnormalities were detected for all timepoints in histological and blood analyses compared to the control group. The C-reactive protein levels were similar between all the groups, indicating no inflammation processes. These findings suggest that dissolved Mo from a degrading implant is physiologically transported and excreted. Furthermore, radiographic and µCT analyses revealed excellent radiopacity of Mo in tissues. These findings and the unique combination with its extraordinary mechanical properties make Mo an interesting alternative for established BMMs.

scholarly journals Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium?

2002 ◽  
Vol 88 (4) ◽  
pp. 555-562 ◽  
Author(s):  
M. Weindlmayr-Goettel ◽  
H. Gilly ◽  
H.G. Kress
Keyword(s):  
Degradation Rate ◽  
Ester Hydrolysis ◽  
In Vitro Degradation
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