Formulation of In Situ Chemically Cross-Linked Hydrogel Depots for Protein Release: From the Blob Model Perspective

2014 ◽  
Vol 16 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Yu Yu ◽  
Ying Chau
Keyword(s):  
Protein Release ◽  
Blob Model

Injectable and in situ gelling hydrogels for modified protein release

2009 ◽  
Vol 39 (6) ◽  
pp. 903-909 ◽  
Author(s):  
L. Pescosolido ◽  
S. Miatto ◽  
C. Di Meo ◽  
C. Cencetti ◽  
T. Coviello ◽  
...  
Keyword(s):  
Protein Release ◽  
In Situ Gelling

scholarly journals Correction: Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment

RSC Advances ◽  
2018 ◽  
Vol 8 (72) ◽  
pp. 41376-41376
Author(s):  
Min Kyung Khang ◽  
Jun Zhou ◽  
Yihui Huang ◽  
Amirhossein Hakamivala ◽  
Shuxin Li ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Protein Release ◽  
Cell Entrapment ◽  
In Situ Gelling

Correction for ‘Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment’ by Min Kyung Khang et al., RSC Adv., 2018, 8, 34625–34633.

scholarly journals Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment

RSC Advances ◽  
2018 ◽  
Vol 8 (60) ◽  
pp. 34625-34633 ◽  
Author(s):  
Min Kyung Khang ◽  
Jun Zhou ◽  
Yihui Huang ◽  
Amirhossein Hakamivala ◽  
Liping Tang
Keyword(s):  
Body Temperature ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Metastatic Cancer ◽  
Protein Release ◽  
Cell Entrapment ◽  
In Situ Gelling ◽  
Metastatic Cancer Cells

At body temperature, thermosensitive nanoparticles release erythropoietin to lure metastatic cancer cells.

Effect of substituted phenols on movement of water and protein across the intestine

1961 ◽  
Vol 200 (2) ◽  
pp. 305-308 ◽  
Author(s):  
C. S. Tidball
Keyword(s):  
Oxygen Uptake ◽  
Oxidative Phosphorylation ◽  
Sea Urchin ◽  
Water Movement ◽  
Protein Release ◽  
Substituted Phenols ◽  
Sea Urchin Eggs

The action of three substituted phenols on intestinal net water movement in jejunal loops in situ has been studied in the anesthetized dog. The ability of these compounds to influence intestinal net water movement paralleled their previously reported ability to stimulate oxygen uptake and to produce cessation of cleavage in fertilized sea urchin eggs which are thought to be manifestation of their property to uncouple oxidative phosphorylation. Thus two effective uncouplers produced decreases in net absorption at a concentration of 1 x 10–3 m/l. and net secretion at a concentration of 1 x 10–2 m/l. A less effective uncoupler produced no change in water movement at a concentration of 1 x 10–3 m/l. and only a decrease in net absorption at a concentration of 1 x 10–2 m/l. The substituted phenols produced increases in the amount of protein which could be recovered from the lumen, but the changes in water movement produced by substituted phenols were independent of the mechanism responsible for the protein release.

Controllable multi-phase protein release from in-situ hydrolyzable hydrogel

2021 ◽  
Author(s):  
Chi Ming Laurence Lau ◽  
Ghodsiehsadat Jahanmir ◽  
Yu Yu ◽  
Ying Chau
Keyword(s):  
Protein Release ◽  
Phase Protein ◽  
Multi Phase

Aptamer-Functionalized In Situ Injectable Hydrogel for Controlled Protein Release

2010 ◽  
Vol 11 (10) ◽  
pp. 2724-2730 ◽  
Author(s):  
Boonchoy Soontornworajit ◽  
Jing Zhou ◽  
Zhaoyang Zhang ◽  
Yong Wang
Keyword(s):  
Protein Release ◽  
Injectable Hydrogel

scholarly journals In situ preparation and protein delivery of silicate–alginate composite microspheres with core-shell structure

2011 ◽  
Vol 8 (65) ◽  
pp. 1804-1814 ◽  
Author(s):  
Chengtie Wu ◽  
Wei Fan ◽  
Michael Gelinsky ◽  
Yin Xiao ◽  
Jiang Chang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Shell Structure ◽  
Protein Delivery ◽  
Protein Release ◽  
Fickian Diffusion ◽  
Core Shell ◽  
Burst Release ◽  
The Core ◽  
Core Shell Structure

The efficient loading and sustained release of proteins from bioactive microspheres remain a significant challenge. In this study, we have developed bioactive microspheres which can be loaded with protein and then have a controlled rate of protein release into a surrounding medium. This was achieved by preparing a bioactive microsphere system with core-shell structure, combining a calcium silicate (CS) shell with an alginate (A) core by a one-step in situ method. The result was to improve the microspheres' protein adsorption and release, which yielded a highly bioactive material with potential uses in bone repair applications. The composition and the core-shell structure, as well as the formation mechanism of the obtained CS–A microspheres, were investigated by X-ray diffraction, optical microscopy, scanning electron microscopy, energy dispersive spectrometer dot and line-scanning analysis. The protein loading efficiency reached 75 per cent in CS–A microspheres with a core-shell structure by the in situ method. This is significantly higher than that of pure A or CS–A microspheres prepared by non- in situ method, which lack a core-shell structure. CS–A microspheres with a core-shell structure showed a significant decrease in the burst release of proteins, maintaining sustained release profile in phosphate-buffered saline (PBS) at both pH 7.4 and 4.3, compared with the controls. The protein release from CS–A microspheres is predominantly controlled by a Fickian diffusion mechanism. The CS–A microspheres with a core-shell structure were shown to have improved apatite-mineralization in simulated body fluids compared with the controls, most probably owing to the existence of bioactive CS shell on the surface of the microspheres. Our results indicate that the core-shell structure of CS–A microspheres play an important role in enhancing protein delivery and mineralization, which makes these composite materials promising candidates for application in bone tissue regeneration.

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