Aptamer-Functionalized In Situ Injectable Hydrogel for Controlled Protein Release

2010 ◽  
Vol 11 (10) ◽  
pp. 2724-2730 ◽  
Author(s):  
Boonchoy Soontornworajit ◽  
Jing Zhou ◽  
Zhaoyang Zhang ◽  
Yong Wang
Keyword(s):  
Protein Release ◽  
Injectable Hydrogel

Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration

2019 ◽  
Vol 7 (15) ◽  
pp. 2442-2453 ◽  
Author(s):  
Caoxin Tang ◽  
Brian D. Holt ◽  
Zoe M. Wright ◽  
Anne M. Arnold ◽  
Alexandra C. Moy ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Cartilage Regeneration ◽  
Functionalized Graphene ◽  
Injectable Hydrogel ◽  
Amine Functionalized ◽  
Cartilage Therapy

Chemically functionalized graphene covalently reactsin situwith chondroitin sulfate to form an enhanced, injectable hydrogel for potential cartilage therapy.

A Facile Strategy for In Situ Controlled Delivery of Doxorubicin with a pH-Sensitive Injectable Hydrogel

Nano LIFE ◽  
2014 ◽  
Vol 04 (03) ◽  
pp. 1441001 ◽  
Author(s):  
Jun Chen ◽  
Xiaojian Li ◽  
Liqian Gao ◽  
Yi Hu ◽  
Wen Zhong ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Controlled Delivery ◽  
Cell Uptake ◽  
Injectable Hydrogel ◽  
Poorly Soluble ◽  
Poly Ethylene ◽  
Novel Strategy ◽  
Ph Sensitive Polymer ◽  
Tunable Stiffness

In light of the challenges along with the traditional intravenous administration of chemotherapeutics, injectable hydrogel-drug system emerges as a powerful tool for noninvasive and in situ controlled-release of drugs. Herein, we report a novel strategy of drug delivery system with pH responsive injectable hydrogels by taking advantages of two biomaterials. The first one is a pH sensitive polymer-drug (prodrug) conjugate, poly (ethylene glycol)–doxorubicin (MPEG–DOX) with hydrazone linkage. This prodrug interacted with a second biomaterial, α-cyclodextrin (α-CD) under mild conditions and subsequently formed the hydrogels in minutes with tunable stiffness. The gels showed a sustained release behavior dependent on the surrounding pH and released drugs effectively killed tumor cells (MCF-7). The quick cell uptake and efficient intracellular delivery of DOX were observed under a confocal microscope. This study thus provides a novel and simple drug encapsulation strategy to deliver poorly soluble drugs in situ for a potential targeted chemotherapy.

Injectable and in situ gelling hydrogels for modified protein release

2009 ◽  
Vol 39 (6) ◽  
pp. 903-909 ◽  
Author(s):  
L. Pescosolido ◽  
S. Miatto ◽  
C. Di Meo ◽  
C. Cencetti ◽  
T. Coviello ◽  
...  
Keyword(s):  
Protein Release ◽  
In Situ Gelling

A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis

Biomaterials ◽  
2017 ◽  
Vol 134 ◽  
pp. 128-142 ◽  
Author(s):  
Yanxian Feng ◽  
Qiu Li ◽  
Dang Wu ◽  
Yiming Niu ◽  
Cheng Yang ◽  
...  
Keyword(s):  
Growth Factors ◽  
Endogenous Growth ◽  
Injectable Hydrogel

scholarly journals Correction: Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment

RSC Advances ◽  
2018 ◽  
Vol 8 (72) ◽  
pp. 41376-41376
Author(s):  
Min Kyung Khang ◽  
Jun Zhou ◽  
Yihui Huang ◽  
Amirhossein Hakamivala ◽  
Shuxin Li ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Protein Release ◽  
Cell Entrapment ◽  
In Situ Gelling

Correction for ‘Preparation of a novel injectable in situ-gelling nanoparticle with applications in controlled protein release and cancer cell entrapment’ by Min Kyung Khang et al., RSC Adv., 2018, 8, 34625–34633.

Precise in-situ release of microRNA from an injectable hydrogel induces bone regeneration

2021 ◽  
Author(s):  
Minfeng Gan ◽  
Quan Zhou ◽  
Jun Ge ◽  
Jiali Zhao ◽  
Yingjie Wang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Injectable Hydrogel
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