Intracellular Drug Delivery Nanocarriers of Glutathione-Responsive Degradable Block Copolymers Having Pendant Disulfide Linkages

2013 ◽  
Vol 14 (6) ◽  
pp. 2103-2111 ◽  
Author(s):  
Behnoush Khorsand ◽  
Gabriel Lapointe ◽  
Christopher Brett ◽  
Jung Kwon Oh
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages

Disassembly and tumor-targeting drug delivery of reduction-responsive degradable block copolymer nanoassemblies

2019 ◽  
Vol 10 (13) ◽  
pp. 1554-1568 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages

Review on recent strategies to synthesize novel disulfide-containing reductively-degradable block copolymers and their nanoassemblies as being classified with the number, position, and location of the disulfide linkages toward effective tumor-targeting intracellular drug delivery exhibiting enhanced release of encapsulated drugs.

Biodegradable multiblock polyurethane micelles with tunable reduction-sensitivity for on-demand intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (47) ◽  
pp. 24736-24746 ◽  
Author(s):  
Xueling He ◽  
Mingming Ding ◽  
Jiehua Li ◽  
Hong Tan ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Cells ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages ◽  
Drug Delivery Applications

Biodegradable polyurethanes bearing varied amounts of disulfide linkages in the backbone can rapidly enter tumor cells and efficiently transport the encapsulated payloads into cytosol, resulting in controlled inhibition effects against cancer cells. The nanocarriers are promising candidates for on-demand intracellular drug delivery applications.

Morphology Regulation in Redox Destructible Amphiphilic Block Copolymers and Impact on Intracellular Drug Delivery

2018 ◽  
Vol 18 (7) ◽  
pp. 1800057 ◽  
Author(s):  
Raju Bej ◽  
Jayita Sarkar ◽  
Debes Ray ◽  
Vinod K. Aswal ◽  
Suhrit Ghosh
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Intracellular Drug Delivery

scholarly journals Poly(amidoamine) dendrimer–drug conjugates with disulfide linkages for intracellular drug delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (11) ◽  
pp. 2112-2121 ◽  
Author(s):  
Yunus E. Kurtoglu ◽  
Raghavendra S. Navath ◽  
Bing Wang ◽  
Sujatha Kannan ◽  
Robert Romero ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Conjugates ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages

Redox-responsive micelles self-assembled from dynamic covalent block copolymers for intracellular drug delivery

2015 ◽  
Vol 17 ◽  
pp. 193-200 ◽  
Author(s):  
Qinglai Yang ◽  
Lianjiang Tan ◽  
Changyu He ◽  
Bingya Liu ◽  
Yuhong Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Self Assembled

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

scholarly journals Single Domain Antibodies as Carriers for Intracellular Drug Delivery: A Proof of Principle Study

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 927
Author(s):  
Sebas D. Pronk ◽  
Erik Schooten ◽  
Jurgen Heinen ◽  
Esra Helfrich ◽  
Sabrina Oliveira ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Single Domain ◽  
Drug Conjugates ◽  
Intracellular Drug Delivery ◽  
Internalization Rate ◽  
Single Domain Antibodies ◽  
Different Characteristics

Antibody-drug conjugates (ADCs) are currently used for the targeted delivery of drugs to diseased cells, but intracellular drug delivery and therefore efficacy may be suboptimal because of the large size, slow internalization and ineffective intracellular trafficking of the antibody. Using a phage display method selecting internalizing phages only, we developed internalizing single domain antibodies (sdAbs) with high binding affinity to rat PDGFRβ, a receptor involved in different types of diseases. We demonstrate that these constructs have different characteristics with respect to internalization rates but all traffic to lysosomes. To compare their efficacy in targeted drug delivery, we conjugated the sdAbs to a cytotoxic drug. The conjugates showed improved cytotoxicity correlating to their internalization speed. The efficacy of the conjugates was inhibited in the presence of vacuolin-1, an inhibitor of lysosomal maturation, suggesting lysosomal trafficking is needed for efficient drug release. In conclusion, sdAb constructs with different internalization rates can be designed against the same target, and sdAbs with a high internalization rate induce more cell killing than sdAbs with a lower internalization rate in vitro. Even though the overall efficacy should also be tested in vivo, sdAbs are particularly interesting formats to be explored to obtain different internalization rates.

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