Triply Triggered Doxorubicin Release From Supramolecular Nanocontainers

2011 ◽  
Vol 13 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Xian Jun Loh ◽  
Jesús del Barrio ◽  
Pearl Pei Chern Toh ◽  
Tung-Chun Lee ◽  
Dezhi Jiao ◽  
...  
Keyword(s):  
Supramolecular Nanocontainers ◽  
Doxorubicin Release

Photoresponsive lipid-polymer hybrid nanoparticles for controlled doxorubicin release

2017 ◽  
Vol 28 (25) ◽  
pp. 255101 ◽  
Author(s):  
Cuiping Yao ◽  
Ming Wu ◽  
Cecheng Zhang ◽  
Xinyi Lin ◽  
Zuwu Wei ◽  
...  
Keyword(s):  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Doxorubicin Release

AMD3100-tagged nano-gold as a targeting nanocarrier for delivery of doxorubicin into lung cancer cells

2021 ◽  
Vol 11 (5) ◽  
pp. 618-626
Author(s):  
Yali Liu ◽  
Changpeng Hu ◽  
Min Zhou ◽  
Qian Zhang ◽  
Qin Tang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Acquired Resistance ◽  
Lung Cancer Cells ◽  
Cxcr4 Antagonist ◽  
Au Nps ◽  
Nano Gold ◽  
Dependent Model ◽  
Doxorubicin Release

Doxorubicin (DOX) is widely used as a traditional chemotherapy drug in tumor treatment, but its dose-dependent side effects make it susceptible to acquired resistance. CXCR4 is a chemokine receptor that has high expression in many cancers, including lung cancer. In this work, we studied the possibility of using CXCR4 antagonist, AMD3100, as a targeting molecule to targeted delivery of DOX to CXCR4 expressing lung cancer cells through conjugated gold nanoparticles (Au NPs). DOX was intercalated inside the pH-responsive doublestrand DNA (dsDNA) and then conveniently loaded onto the Au NPs. The CXCR4 antagonist, AMD3100, was bonded with LA-PEG, and then conjugated to the surface of Au-S bond. The doxorubicin release from AuNPs@DOX@AMD3100 NPs was in a pH-dependent model, and specificity of AuNPs@DOX@AMD3100 nanoparticle was verified by using free DOX and Au@DOX NPs as control. Results in this work not only confirmed the possibility of using AMD3100 as a targeting ligand for tumor-targeted treatment, but also suggested that the non-toxic Au NPs is a prospect nanocarrier for target design of cancer therapy.

Using Fluorescence Lifetime Imaging Microscopy to Monitor Theranostic Nanoparticle Uptake and Intracellular Doxorubicin Release

ACS Nano ◽  
2013 ◽  
Vol 7 (11) ◽  
pp. 10175-10189 ◽  
Author(s):  
Johan S. Basuki ◽  
Hien T.T. Duong ◽  
Alexander Macmillan ◽  
Rafael B. Erlich ◽  
Lars Esser ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
Fluorescence Lifetime Imaging Microscopy ◽  
Fluorescence Lifetime Imaging ◽  
Nanoparticle Uptake ◽  
Lifetime Imaging ◽  
Doxorubicin Release

scholarly journals Time-lapse live cell imaging to monitor doxorubicin release from DNA origami nanostructures

2018 ◽  
Vol 6 (11) ◽  
pp. 1605-1612 ◽  
Author(s):  
Yun Zeng ◽  
Jiajun Liu ◽  
Shuo Yang ◽  
Wenyan Liu ◽  
Liang Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Time Lapse ◽  
Dna Origami ◽  
Live Cell ◽  
Doxorubicin Release

DNA origami nanostructures can serve as a promising carrier for drug delivery due to the outstanding programmability and biocompatibility.

scholarly journals Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2646-2649 ◽  
Author(s):  
Lamiaa M. A. Ali ◽  
Emna Mathlouthi ◽  
Maëlle Cahu ◽  
Saad Sene ◽  
Morgane Daurat ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Prussian Blue ◽  
Cancer Cells ◽  
High Efficiency ◽  
Synergic Effect ◽  
Photon Irradiation ◽  
Two Photon ◽  
Prussian Blue Nanoparticles ◽  
Doxorubicin Release

Mn2+-doped Prussian blue nanoparticles loaded with doxorubicin present high efficiency for combined photothermal and chemotherapy of cancer cells with a synergic effect under two-photon irradiation.

Onion-structure bionic hydrogel capsules based on chitosan for regulating doxorubicin release

2019 ◽  
Vol 209 ◽  
pp. 152-160 ◽  
Author(s):  
Wei Zhang ◽  
Xin Jin ◽  
Heng Li ◽  
Cheng-xiong Wei ◽  
Cheng-wei Wu
Keyword(s):  
Doxorubicin Release ◽  
Hydrogel Capsules

DPD studies on mixed micelles self-assembled from MPEG-PDEAEMA and MPEG-PCL for controlled doxorubicin release

2019 ◽  
Vol 178 ◽  
pp. 56-65 ◽  
Author(s):  
Chufen Yang ◽  
Cong Yuan ◽  
Wenyao Liu ◽  
Jianwei Guo ◽  
Dachun Feng ◽  
...  
Keyword(s):  
Mixed Micelles ◽  
Self Assembled ◽  
Doxorubicin Release

scholarly journals PEGylated and poloxamer-modified chitosan nanoparticles incorporating a lysine-based surfactant for pH-triggered doxorubicin release

2016 ◽  
Vol 138 ◽  
pp. 117-127 ◽  
Author(s):  
Laís E. Scheeren ◽  
Daniele R. Nogueira ◽  
Letícia B. Macedo ◽  
M.Pilar Vinardell ◽  
Montserrat Mitjans ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Modified Chitosan ◽  
Doxorubicin Release

Controlled drug delivery for cancer cell treatment via magnetic doxorubicin imprinted silica nanoparticles

2020 ◽  
Vol 56 (70) ◽  
pp. 10255-10258 ◽  
Author(s):  
Maria Nerantzaki ◽  
Aude Michel ◽  
Emmanuel Briot ◽  
Jean Michel Siaugue ◽  
Christine Ménager ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Controlled Drug Delivery ◽  
Alternating Magnetic Field ◽  
Doxorubicin Release

Magnetic doxorubicin imprinted silica nanoparticles for remotely triggered doxorubicin release upon applying an alternating magnetic field.

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