Photo-Cross-Linked Biodegradable Poly(Ester Anhydride) Networks Prepared from Alkenylsuccinic Anhydride Functionalized Poly(ε-caprolactone) Precursors

2011 ◽  
Vol 12 (7) ◽  
pp. 2806-2814 ◽  
Author(s):  
Risto A. Hakala ◽  
Harri Korhonen ◽  
Ville V. Meretoja ◽  
Jukka V. Seppälä
Keyword(s):  
Alkenylsuccinic Anhydride ◽  
Biodegradable Poly

Synthesis of Grafted Biodegradable Poly(ε-caprolactone) as Antibacterial and Antifungal Agent

2020 ◽  
Vol 62 (6) ◽  
pp. 697-705
Author(s):  
Sarra Benguella ◽  
Aicha Hachemaoui ◽  
Ahmed Yahiaoui ◽  
Abdelkader Dehbi
Keyword(s):  
Antifungal Agent ◽  
Biodegradable Poly ◽  
Antibacterial And Antifungal

scholarly journals Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle

2021 ◽  
Vol 22 (11) ◽  
pp. 5557
Author(s):  
Tao-Chieh Yang ◽  
Shih-Jung Liu ◽  
Wei-Lun Lo ◽  
Shu-Mei Chen ◽  
Ya-Ling Tang ◽  
...  
Keyword(s):  
Cell Line ◽  
Therapeutic Index ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Therapeutic Benefits ◽  
Biodegradable Poly ◽  
Anti Tumor Activity

Glioblastoma multiforme (GBM) has remained one of the most lethal and challenging cancers to treat. Previous studies have shown encouraging results when irinotecan was used in combination with temozolomide (TMZ) for treating GBM. However, irinotecan has a narrow therapeutic index: a slight dose increase in irinotecan can induce toxicities that outweigh its therapeutic benefits. SN-38 is the active metabolite of irinotecan that accounts for both its anti-tumor efficacy and toxicity. In our previous paper, we showed that SN-38 embedded into 50:50 biodegradable poly[(d,l)-lactide-co-glycolide] (PLGA) microparticles (SMPs) provides an efficient delivery and sustained release of SN-38 from SMPs in the brain tissues of rats. These properties of SMPs give them potential for therapeutic application due to their high efficacy and low toxicity. In this study, we tested the anti-tumor activity of SMP-based interstitial chemotherapy combined with TMZ using TMZ-resistant human glioblastoma cell line-derived xenograft models. Our data suggest that treatment in which SMPs are combined with TMZ reduces tumor growth and extends survival in mice bearing xenograft tumors derived from both TMZ-resistant and TMZ-sensitive human glioblastoma cell lines. Our findings demonstrate that combining SMPs with TMZ may have potential as a promising strategy for the treatment of GBM.

scholarly journals Mechanism of Elastic Properties of Biodegradable Poly[(R)-3-Hydroxybutyrate-co-4-hydroxybutyrate] Films Revealed by Synchrotron Radiation

ACS Omega ◽  
2021 ◽  
Author(s):  
Yuki Kawamura ◽  
Hongyi Gan ◽  
Taizo Kabe ◽  
Akira Maehara ◽  
Satoshi Kimura ◽  
...  
Keyword(s):  
Synchrotron Radiation ◽  
Elastic Properties ◽  
Biodegradable Poly

scholarly journals Capsid-like biodegradable poly-glycolic acid nanoparticles for a long-time release of nucleic acid molecules

2021 ◽  
Author(s):  
Clara Guido ◽  
Mariangela Testini ◽  
Stefania D’Amone ◽  
Barbara Cortese ◽  
Maria Grano ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Glycolic Acid ◽  
Cell Transfection ◽  
Biodegradable Poly ◽  
Long Time ◽  
2D And 3D

Capsid-like PGA nanoparticles (NPs) allow sustained cell transfection in 2D and 3D configurations.

scholarly journals Chronic Glaucoma Using Biodegradable Microspheres to Induce Intraocular Pressure Elevation. Six-Month Follow-Up

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 682
Author(s):  
Maria Jesus Rodrigo ◽  
David Garcia-Herranz ◽  
Manuel Subias ◽  
Teresa Martinez-Rincón ◽  
Silvia Mendez-Martínez ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Clinical Signs ◽  
Progressive Increase ◽  
Biodegradable Microspheres ◽  
Fiber Layer ◽  
Chronic Glaucoma ◽  
Biodegradable Poly ◽  
Contralateral Eye

 Background: To compare two prolonged animal models of glaucoma over 24 weeks of follow-up. A novel pre-trabecular model of chronic glaucoma was achieved by injection of biodegradable poly lactic-co-glycolic acid (PLGA) microspheres (10–20 µm) (Ms20/10) into the ocular anterior chamber to progressively increase ocular hypertension (OHT). Methods: Rat right eyes were injected to induce OHT: 50% received a suspension of Ms20/10 in the anterior chamber at 0, 2, 4, 8, 12, 16 and 20 weeks, and the other 50% received a sclerosing episcleral vein injection biweekly (EPIm). Ophthalmological clinical signs, intraocular pressure (IOP), neuroretinal functionality measured by electroretinography (ERG), and structural analysis of the retina, retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) protocols using optical coherence tomography (OCT) and histological exams were performed. Results: Both models showed progressive neuroretinal degeneration (p < 0.05), and contralateral eye affectation. The Ms20/10 model showed a more progressive increase in IOP and better preservation of ocular surface. Although no statistical differences were found between models, the EPIm showed a tendency to produce thicker retinal and thinner GCL thicknesses, slower latency and smaller amplitude as measured using ERG, and more aggressive disturbances in retinal histology. In both models, while the GCL showed the greatest percentage loss of thickness, the RNFL showed the greatest and earliest rate of thickness loss. Conclusions: The intracameral model with biodegradable microspheres resulted more like the conditions observed in humans. It was obtained by a less-aggressive mechanism, which allows for adequate study of the pathology over longer periods. 

Biodegradable poly(N-isopropylacrylamide-co-N-maleylgelatin) hydrogels with adjustable swelling behavior

2019 ◽  
Vol 297 (5) ◽  
pp. 763-769 ◽  
Author(s):  
Feifei Xin ◽  
Meiyu Sui ◽  
Xisheng Liu ◽  
Cong Zhao ◽  
Yueqin Yu
Keyword(s):  
Swelling Behavior ◽  
Biodegradable Poly
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