scholarly journals Capsid-like biodegradable poly-glycolic acid nanoparticles for a long-time release of nucleic acid molecules

2021 ◽  
Author(s):  
Clara Guido ◽  
Mariangela Testini ◽  
Stefania D’Amone ◽  
Barbara Cortese ◽  
Maria Grano ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Glycolic Acid ◽  
Cell Transfection ◽  
Biodegradable Poly ◽  
Long Time ◽  
2D And 3D

Capsid-like PGA nanoparticles (NPs) allow sustained cell transfection in 2D and 3D configurations.

Experimental Myringoplasty

1980 ◽  
Vol 3 (6) ◽  
pp. 354-357 ◽  
Author(s):  
L. Feenstra ◽  
B.W.C. Van Der Ven ◽  
F.E. Kohn ◽  
J. Feijen
Keyword(s):  
Lactic Acid ◽  
Bisphenol A ◽  
Tympanic Membrane ◽  
Biodegradable Polymers ◽  
Glycolic Acid ◽  
Tissue Reaction ◽  
Biodegradable Poly ◽  
One Year ◽  
Poly Carbonate ◽  
Tympanic Membranes

Artificial eardrums made from biodegradable poly(D, L-lactic acid), poly(glycolic acid) and poly(ß-benzyl-L-aspartate-co-L-leucine) 50/50, and made from the microporous poly(tetrafluoroethylene) and bisphenol-A poly(carbonate) membranes were implanted into the ear and as a reference subcutaneously in rats. The implants were histologically examined for periods up to one year. From the biodegradable polymers studied the poly(ß-benzyl-L-aspartate-co-L-leucine) 50/50 evoked the least tissue reaction and the newly formed tympanic membranes are the best in terms of thickness and overall integrity. The microporous poly(tetrafluoroethylene) membrane can be considered as a valuable support for the formation of a reinforced tympanic membrane.

A 3D Numerical Wave Tank for Coastal Engineering Studies

2017 ◽  
Vol 372 ◽  
pp. 1-10 ◽  
Author(s):  
Eric Didier ◽  
Paulo R.F. Teixeira ◽  
Maria Graça Neves
Keyword(s):  
Wave Tank ◽  
Active Absorption ◽  
Wave Flume ◽  
Long Time ◽  
Mean Water Level ◽  
Wave Maker ◽  
Numerical Beach ◽  
2D And 3D ◽  
3D Applications ◽  
Absorption Wave

This paper presents the validation of active and passive, made by a dissipation beach, numerical absorbing methods implemented in RANS-VOF FLUENT® code for modelling long time series of wave propagation interacting with coastal structures. Verification of both numerical techniques was performed in 2D – wave flume, and 3D – wave tank, this one using a multiple active absorption wave makers. The active absorption wave maker allows maintaining the incident wave generation and the mean water level along the time. Good results were obtained for 2D and 3D applications for active absorption wave maker at the generation boundary and both numerical beach and active absorption at the end of the flume/tank.

scholarly journals Tunability of Biodegradable Poly(amine-co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications

2018 ◽  
Vol 19 (9) ◽  
pp. 3861-3873 ◽  
Author(s):  
Amy C. Kauffman ◽  
Alexandra S. Piotrowski-Daspit ◽  
Kay H. Nakazawa ◽  
Yuhang Jiang ◽  
Amit Datye ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Biomedical Applications ◽  
Nucleic Acid Delivery ◽  
Biodegradable Poly

The Use of Rapid Prototyping to Fabricate Liver Tissue Engineering Scaffold

2011 ◽  
Vol 328-330 ◽  
pp. 658-661
Author(s):  
Singare Sekou ◽  
Shou Yan Zhong ◽  
Zhen Zhong Sun
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Rapid Prototyping ◽  
Glycolic Acid ◽  
Tissue Engineering Scaffold ◽  
Liver Tissue Engineering ◽  
Biodegradable Poly ◽  
Future Direction ◽  
Silicone Mould ◽  
Printing Machine

In this papers, the authors described a rapid prototyping method to produce vascularized tissue such liver scaffold for tissue engineering applications. A scaffold with interconnected channel was designed using CAD environment. The data were transferred to a Polyjet 3D Printing machine (Eden 250, Object, Israel) to generate the models. Based on the 3D Printing model, a PDMS (polydimethyl-silicone) mould was created which can be used to cast the biodegradable poly (L-lactic-co-glycolic acid) (PLGA )material. The advantages and limitations of Rapid Prototyping (RP) techniques as well as the future direction of RP development in tissue engineering scaffold fabrication were reviewed.

scholarly journals Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs

2016 ◽  
Vol 46 (12) ◽  
pp. 2216-2222
Author(s):  
Tiago Barbalho Lima ◽  
Ivan Martinez Padua ◽  
Karina Kamachi Kobashigawa ◽  
Marcela Aldrovani ◽  
Flor Diana Yocoay Claros Chacaltana ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Glycolic Acid ◽  
Treatment Protocol ◽  
Ocular Inflammation ◽  
Intraocular Inflammation ◽  
Acid Copolymer ◽  
Biodegradable Poly ◽  
Pars Plana ◽  
Intravitreal Dexamethasone ◽  
Late Postoperative Period

ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.

Bioadhesives in Biomedical Applications: A Critical Review

2020 ◽  
Vol 8 (2) ◽  
pp. 130-152
Author(s):  
Aishee Dey ◽  
Proma Bhattacharya ◽  
Sudarsan Neogi
Keyword(s):  
Clinical Trials ◽  
Biomedical Applications ◽  
Glycolic Acid ◽  
Mucus Layer ◽  
Poly Ethylene Glycol ◽  
Naturally Occurring ◽  
Long Time ◽  
Biomedical Industry ◽  
Poly Ethylene ◽  
Poor Adhesion

The necessity for a long time contact between the drug and mucus layer/epithelial cell or a combination of the two requires a bioadhesive. A bioadhesive is known to intensify contact between the two and help in controlled release of drugs. The conventionally used bioadhesives are known to have poor adhesion strength and can have toxic side effects. This review focuses on the various types of polymers and their composites for use as bioadhesives which can overcome the previously mentioned issues. These include some naturally occurring bioadhesives such as collagen, chitosan, albumin, dextran and some synthetic bioadhesives like gelatin, poly(ethylene glycol), poly(acrylic acid), poly(lactic-co-glycolic acid) based bioadhesives. The clinical trials prove the effectiveness of these bioadhesives and they are found to be more efficient than the commercial glues and hence possess great potential for use in the biomedical industry.

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