Well-Defined Poly(2-hydroxyl-3-(2-hydroxyethylamino)propyl methacrylate) Vectors with Low Toxicity and High Gene Transfection Efficiency

2010 ◽  
Vol 11 (6) ◽  
pp. 1437-1442 ◽  
Author(s):  
F. J. Xu ◽  
M. Y. Chai ◽  
W. B. Li ◽  
Y. Ping ◽  
G. P. Tang ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Propyl Methacrylate ◽  
High Gene ◽  
Low Toxicity

Gene-carried chitosan-linked-PEI induced high gene transfection efficiency with low toxicity and significant tumor-suppressive activity

2010 ◽  
Vol 387 (1-2) ◽  
pp. 286-294 ◽  
Author(s):  
Jian-Qing Gao ◽  
Qing-Qing Zhao ◽  
Teng-Fei Lv ◽  
Wu-Ping Shuai ◽  
Jun Zhou ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Suppressive Activity ◽  
High Gene ◽  
Low Toxicity

A general strategy to achieve ultra-high gene transfection efficiency using lipid-nanoparticle composites

Biomaterials ◽  
2014 ◽  
Vol 35 (28) ◽  
pp. 8261-8272 ◽  
Author(s):  
Raviraj Vankayala ◽  
Chi-Shiun Chiang ◽  
Jui-I. Chao ◽  
Chiun-Jye Yuan ◽  
Shyr-Yeu Lin ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
General Strategy ◽  
Lipid Nanoparticle ◽  
High Gene ◽  
Nanoparticle Composites

Self-assembling Janus dendritic polymer for gene delivery with low cytotoxicity and high gene transfection efficiency

2016 ◽  
Vol 4 (39) ◽  
pp. 6462-6467 ◽  
Author(s):  
Sheng-Gang Ding ◽  
Lei Yu ◽  
Long-Hai Wang ◽  
Lin-Ding Wang ◽  
Zhi-Qiang Yu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Dendritic Polymer ◽  
Self Assembling ◽  
High Gene ◽  
Low Cytotoxicity

Polycations have high DNA condensing ability, low immunogenicity, and great adaptability, which make them promising for gene delivery.

An acoustic field-based conformal transfection system for improving gene delivery efficiency

2021 ◽  
Author(s):  
Liting Xie ◽  
Jieqiong Wang ◽  
Shuai Zhao ◽  
Manlin Lai ◽  
Tian'an Jiang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Acoustic Field ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
High Specificity ◽  
Low Toxicity ◽  
Delivery Efficiency

Ultrasound-activated microbubbles destruction is a promising platform for gene delivery due to the low toxicity, non-invasiveness, and high specificity. However, the gene transfection efficiency is still low, especially for suspension...

Cationic niosomes composed of spermine-based cationic lipids mediate high gene transfection efficiency

2012 ◽  
Vol 20 (9) ◽  
pp. 783-792 ◽  
Author(s):  
Orapan Paecharoenchai ◽  
Nattisa Niyomtham ◽  
Tanasait Ngawhirunpat ◽  
Theerasak Rojanarata ◽  
Boon-ek Yingyongnarongkul ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Cationic Lipids ◽  
High Gene ◽  
Cationic Niosomes

Gene-carried chitosan-linked polyethylenimine induced high gene transfection efficiency on dendritic cells

2012 ◽  
Vol 59 (5) ◽  
pp. 346-352 ◽  
Author(s):  
Yu-Zhe Chen ◽  
Xing-Lei Yao ◽  
Gui-Xin Ruan ◽  
Qing-Qing Zhao ◽  
Gu-Ping Tang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
High Gene

Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array

2018 ◽  
Vol 16 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Dong Huang ◽  
Deyao Zhao ◽  
Jinhui Li ◽  
Yuting Wu ◽  
Lili Du ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Basic Research ◽  
Nanoneedle Array ◽  
Contact Frequency ◽  
Delivery Platform ◽  
High Gene ◽  
Free Gene

Background: Delivery of foreign cargoes into cells is of great value for bioengineering research and therapeutic applications. Objective: In this study, we proposed and established a carrier-free gene delivery platform utilizing staggered herringbone channel and silicon nanoneedle array, to achieve high-throughput in vitro gene transfection. </P><P> Methods: With this microchip, fluidic micro vortices could be induced by the staggered-herringboneshaped grooves within the channel, which increased the contact frequency of the cells with the channel substrate. Transient disruptions on the cell membrane were well established by the nanoneedle array on the substrate. </P><P> Result: Compared to the conventional nanoneedle-based delivery system, proposed microfluidic chip achieved flow-through treatment with high gene transfection efficiency (higher than 20%) and ideal cell viability (higher than 95%). It provides a continuous processing environment that can satisfy the transfection requirement of large amounts of biological molecules, showing high potential and promising prospect for both basic research and clinical application.

Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes

2005 ◽  
Vol 102 (3) ◽  
pp. 749-763 ◽  
Author(s):  
Xue-Qing Zhang ◽  
Xu-Li Wang ◽  
Peng-Chi Zhang ◽  
Zhi-Lan Liu ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
High Gene

PLL/PAE/DNA ternary complexes with enhanced endosomal escape ability for efficient and safe gene transfection

2016 ◽  
Vol 40 (11) ◽  
pp. 9806-9812 ◽  
Author(s):  
Zhibing Sun ◽  
Dezhong Zhou
Keyword(s):  
Transfection Efficiency ◽  
Gene Transfection ◽  
Ternary Complexes ◽  
Endosomal Escape ◽  
High Gene

High gene transfection efficiency is achieved by a simple yet versatile PAE oligomer incorporation strategy.

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