Nitric Oxide Releasing Polyurethanes with Covalently Linked Diazeniumdiolated Secondary Amines

2006 ◽  
Vol 7 (3) ◽  
pp. 987-994 ◽  
Author(s):  
Melissa M. Reynolds ◽  
Joseph A. Hrabie ◽  
Bong K. Oh ◽  
Jeffrey K. Politis ◽  
Michael L. Citro ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Secondary Amines ◽  
Covalently Linked ◽  
Nitric Oxide Releasing

scholarly journals Synthesis and Characterization of Controlled Nitric Oxide Release from S-Nitroso-N-Acetyl-d-Penicillamine Covalently Linked to Polyvinyl Chloride (SNAP-PVC)

2018 ◽  
Vol 5 (3) ◽  
pp. 72 ◽  
Author(s):  
Sean Hopkins ◽  
Megan Frost
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Response ◽  
Polyvinyl Chloride ◽  
Light Emitting ◽  
Nitric Oxide Release ◽  
Passive Mechanism ◽  
Controllable Release ◽  
Covalently Linked ◽  
Nitric Oxide Releasing

Polyvinyl chloride (PVC) is one of the most widely used polymers in medicine but has very poor biocompatibility when in contact with tissue or blood. To increase biocompatibility, controlled release of nitric oxide (NO) can be utilized to mitigate and reduce the inflammatory response. A synthetic route is described where PVC is aminated to a specified degree and then further modified by covalently linking S-nitroso-N-acetyl-d-penicillamine (SNAP) groups to the free primary amine sites to create a nitric oxide releasing polymer (SNAP-PVC). Controllable release of NO from SNAP-PVC is described using photoinitiation from light emitting diodes (LEDs). Ion-mediated NO release is also demonstrated as another pathway to provide a passive mechanism for NO delivery. The large range of NO fluxes obtained from the SNAP-PVC films indicate many potential uses in mediating unwanted inflammatory response in blood- and tissue-contacting devices and as a tool for delivering precise amounts of NO in vitro.

Nitric Oxide-Releasing Biomaterials for Biomedical Applications

2016 ◽  
Vol 23 (24) ◽  
pp. 2579-2601 ◽  
Author(s):  
Xin Zhou ◽  
Jimin Zhang ◽  
Guowei Feng ◽  
Jie Shen ◽  
Deling Kong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biomedical Applications ◽  
Nitric Oxide Releasing

scholarly journals Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration

2021 ◽  
Vol 11 (13) ◽  
pp. 6041
Author(s):  
Kwan-Hee Yun ◽  
Mi-Ja Ko ◽  
Yong-Kown Chae ◽  
Koeun Lee ◽  
Ok-Hyung Nam ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Standard Deviation ◽  
Treatment Group ◽  
Root Surface ◽  
Lower Grade ◽  
Histomorphometric Analysis ◽  
Pulp Regeneration ◽  
Pulp Inflammation ◽  
Nitric Oxide Releasing ◽  
Rat Molar

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treatment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard deviation) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

scholarly journals New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies

2021 ◽  
Vol 139 ◽  
pp. 111678
Author(s):  
Alexandru Sava ◽  
Frederic Buron ◽  
Sylvain Routier ◽  
Alina Panainte ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
In Silico ◽  
In Vitro Studies ◽  
Scaffold Design ◽  
Design Synthesis ◽  
Nitric Oxide Releasing

Synthesis and spermicidal activity of a putative nitric oxide-releasing derivative of nonoxynol-9

Contraception ◽  
2004 ◽  
Vol 70 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Matthew J Ingram ◽  
Ronit Glantz ◽  
Charlotte E Hall
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Releasing

Novel Nitric Oxide-Releasing Derivatives of Farnesylthiosalicylic Acid: Synthesis and Evaluation of Antihepatocellular Carcinoma Activity

2011 ◽  
Vol 54 (9) ◽  
pp. 3251-3259 ◽  
Author(s):  
Yong Ling ◽  
Xiaolei Ye ◽  
Zhenzhen Zhang ◽  
Yihua Zhang ◽  
Yisheng Lai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acid Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Nitric Oxide-Donating Derivatives of Chrysin Stimulate Angiogenesis and Upregulating VEGF Production

2011 ◽  
Vol 340 ◽  
pp. 363-368 ◽  
Author(s):  
Xiao Qing Zou ◽  
Yong Lan Ding ◽  
Sheng Ming Peng ◽  
Chang Ping Hu ◽  
Han Wu Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Therapeutic Option ◽  
Therapeutic Angiogenesis ◽  
Vegf Mrna ◽  
No Donor ◽  
Endothelial Migration ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Angiogenesis, the development of new capillaries from pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate to form functional vessels. Endothelial dysfunction and decreased nitric oxide bioavailability may underscore the impairment of angiogenesis. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to therapeutic angiogenesis. In this paper, a novel group of hybrid nitric oxide-releasing chrysin derivatives was synthesized. The results indicated that all these chrysin derivatives exhibited promotion of endothelial migration and tubulogenesis in vitro as well as stimulation angiogenesis in vivo.Furthermore, all compounds released NO upon incubation with phosphate buffer at pH 7.4 and enhanced VEGF secretion and VEGF mRNA expression of endothelial cells. These hybrid ester NO donor prodrugs offer a potential drug design concept for the development of therapeutic or preventive agents for angiogenesis deficiency due to ischemic diseases.

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