Fibroblast Cell Behavior on Bound and Adsorbed Fibronectin onto Hyaluronan and Sulfated Hyaluronan Substrates

2005 ◽  
Vol 6 (2) ◽  
pp. 638-645 ◽  
Author(s):  
R. Barbucci ◽  
A. Magnani ◽  
A. Chiumiento ◽  
D. Pasqui ◽  
I. Cangioli ◽  
...  
Keyword(s):  
Fibroblast Cell ◽  
Cell Behavior

Selective Laser Melted Titanium Alloy for Transgingival Components: Influence of Surface Condition on Fibroblast Cell Behavior

2021 ◽  
Author(s):  
Marie‐Joséphine Crenn ◽  
Aurélie Benoit ◽  
Géraldine Rohman ◽  
Thomas Guilbert ◽  
Olivier Fromentin ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Surface Condition ◽  
Fibroblast Cell ◽  
Cell Behavior

Alteration of Fibroblast Cell Behavior due to Contraction of Substrate

2010 ◽  
Author(s):  
Uday Chippada ◽  
Xue Jiang ◽  
Michelle Previtera ◽  
Rene Schloss ◽  
Bernard Yurke ◽  
...  
Keyword(s):  
Cell Attachment ◽  
Fibroblast Cell ◽  
Cellular Responses ◽  
Cell Behavior ◽  
Cellular Behavior ◽  
Polyacrylamide Hydrogels ◽  
3T3 Fibroblasts ◽  
Nih 3T3

Many researchers have utilized hydrogels as substrates for cell attachment. The stiffness of these substrates has been found to influence the cellular behavior such as morphology, proliferation, growth and differentiation. Lo et al. deformed polyacrylamide substrates with a blunted microneedle and observed the movement of NIH 3T3 fibroblasts. In both pulling and pushing, the cells reversed their direction and moved away from the needle. This shows that cellular behavior is also affected by stretching the underlying substrates. In a previous study, Lin et al. have demonstrated the ability to contract DNA-crosslinked polyacrylamide hydrogels (‘DNA gels’ in short) by addition of crosslinks. Jiang et al. have utilized these DNA gels as substrates to observe the cellular responses of L929 and GFP fibroblasts to both static and dynamic substrate compliances.

scholarly journals Cell behavior on silica-hydroxyapatite coaxial composite

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0246256
Author(s):  
Jesús Alberto Garibay-Alvarado ◽  
Ericka Berenice Herrera-Ríos ◽  
Claudia Lucía Vargas-Requena ◽  
Álvaro de Jesús Ruíz-Baltazar ◽  
Simón Yobanny Reyes-López
Keyword(s):  
Tissue Regeneration ◽  
Water Retention ◽  
Structural Characteristics ◽  
Sol Gel ◽  
Average Diameter ◽  
Fibroblast Cell ◽  
Cell Behavior ◽  
Polymeric Fibers ◽  
20 Nm

Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biomineralization. Hydroxyapatite (HA) is a ceramic material with lots of potential in tissue regeneration, however, its structural characteristics need to be improved for better performance. In this study, silica-hydroxyapatite (SiO2-HA) non-woven ceramic electrospunned membranes were prepared through the sol-gel method. Infrared spectra, scanning electron microscopy and XRD confirmed the structure and composition of composite. The obtained SiO2-HA polymeric fibers had approximately 230±20 nm in diameter and were then sintered at 800°C average diameter decreased to 110±17 nm. Three configurations of the membranes were obtained and tested in vitro, showing that the composite of SiO2-HA fibers showed a high percentage of viability on a fibroblast cell line. It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration.

scholarly journals Attachment and Growth of Fibroblast Cells on Poly (2-Methoxyethyl Acrylate) Analog Polymers as Coating Materials

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 461
Author(s):  
Rubaiya Anjum ◽  
Kei Nishida ◽  
Haruka Matsumoto ◽  
Daiki Murakami ◽  
Shingo Kobayashi ◽  
...  
Keyword(s):  
Fibroblast Cell ◽  
Carbon Chain ◽  
Dermal Fibroblasts ◽  
Cell Behavior ◽  
Carbon Chain Length ◽  
Fibroblast Cells ◽  
Coating Materials ◽  
Subsequent Behavior ◽  
Normal Human ◽  
Normal Human Dermal Fibroblasts

The regulation of adhesion and the subsequent behavior of fibroblast cells on the surface of biomaterials is important for successful tissue regeneration and wound healing by implanted biomaterials. We have synthesized poly(ω-methoxyalkyl acrylate)s (PMCxAs; x indicates the number of methylene carbons between the ester and ethyl oxygen), with a carbon chain length of x = 2–6, to investigate the regulation of fibroblast cell behavior including adhesion, proliferation, migration, differentiation and collagen production. We found that PMC2A suppressed the cell spreading, protein adsorption, formation of focal adhesion, and differentiation of normal human dermal fibroblasts, while PMC4A surfaces enhanced them compared to other PMCxAs. Our findings suggest that fibroblast activities attached to the PMCxA substrates can be modified by changing the number of methylene carbons in the side chains of the polymers. These results indicate that PMCxAs could be useful coating materials for use in skin regeneration and wound dressing applications.

scholarly journals Enamel matrix derivative improves gingival fibroblast cell behavior cultured on titanium surfaces

2015 ◽  
Vol 20 (4) ◽  
pp. 685-695 ◽  
Author(s):  
Yulan Wang ◽  
Yufeng Zhang ◽  
Dai Jing ◽  
Yang Shuang ◽  
Richard J. Miron
Keyword(s):  
Fibroblast Cell ◽  
Enamel Matrix Derivative ◽  
Cell Behavior ◽  
Gingival Fibroblast ◽  
Enamel Matrix ◽  
Titanium Surfaces ◽  
Matrix Derivative

Fibroblast cell behavior on chemically functionalized carbon nanomaterials

2009 ◽  
Vol 29 (3) ◽  
pp. 719-725 ◽  
Author(s):  
YeoHeung Yun ◽  
Zhongyun Dong ◽  
Zongqin Tan ◽  
Mark J. Schulz ◽  
Vesslin Shanov
Keyword(s):  
Carbon Nanomaterials ◽  
Fibroblast Cell ◽  
Cell Behavior

Scanning electron microscopic study of collagen fibrillogenesis and extracellular compartmentalization in the chick embryo tendon

1986 ◽  
Vol 44 ◽  
pp. 208-209
Author(s):  
Grace C.H. Yang
Keyword(s):  
Chick Embryo ◽  
Extracellular Space ◽  
Fibroblast Cell ◽  
Collagen Fibrils ◽  
Electron Microscopic ◽  
Voltage Electron ◽  
Scanning Electron Microscopic Study ◽  
Microscopic Studies ◽  
And Function

The size and organization of collagen fibrils in the extracellular matrix is an important determinant of tissue structure and function. The synthesis and deposition of collagen involves multiple steps which begin within the cell and continue in the extracellular space. High-voltage electron microscopic studies of the chick embryo cornea and tendon suggested that the extracellular space is compartmentalized by the fibroblasts for the regulation of collagen fibril, bundle, and tissue specific macroaggregate formation. The purpose of this study is to gather direct evidence regarding the association of the fibroblast cell surface with newly formed collagen fibrils, and to define the role of the fibroblast in the control and the precise positioning of collagen fibrils, bundles, and macroaggregates during chick tendon development.

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

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