In Vitro Cytotoxicity of Injectable and Biodegradable Poly(propylene fumarate)-Based Networks:  Unreacted Macromers, Cross-Linked Networks, and Degradation Products

2003 ◽  
Vol 4 (4) ◽  
pp. 1026-1033 ◽  
Author(s):  
Mark D. Timmer ◽  
Heungsoo Shin ◽  
R. Adam Horch ◽  
Catherine G. Ambrose ◽  
Antonios G. Mikos
Keyword(s):  
Degradation Products ◽  
In Vitro Cytotoxicity ◽  
Biodegradable Poly ◽  
Poly Propylene

In vitro cytotoxicity andin vivo biocompatibility of poly(propylene fumarate-co-ethylene glycol) hydrogels

1999 ◽  
Vol 46 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Laura J. Suggs ◽  
Matthew S. Shive ◽  
C. Alejandra Garcia ◽  
James M. Anderson ◽  
Antonios G. Mikos
Keyword(s):  
Ethylene Glycol ◽  
In Vitro Cytotoxicity ◽  
Poly Propylene

scholarly journals Identification, isolation, structural characterization, in silico toxicity prediction and in vitro cytotoxicity assay of simeprevir acidic and oxidative degradation products

RSC Advances ◽  
2020 ◽  
Vol 10 (70) ◽  
pp. 42816-42826
Author(s):  
Rasha M. Ahmed ◽  
Marwa A. A. Fayed ◽  
Mohammed F. El-Behairy ◽  
Inas A. Abdallah
Keyword(s):  
Chronic Hepatitis ◽  
Degradation Products ◽  
Antiviral Drug ◽  
Oxidative Degradation ◽  
In Vitro Cytotoxicity ◽  
Toxicity Prediction ◽  
Direct Acting Antiviral ◽  
In Silico Toxicity ◽  
Direct Acting

Simeprevir is a new direct-acting antiviral drug used for the treatment of chronic hepatitis C.

Isolation, characterization using LC-ESI-QTOF, NMR and in vitro cytotoxicity assay of niclosamide forced degradation products

2017 ◽  
Vol 136 ◽  
pp. 148-155 ◽  
Author(s):  
Johnsirani P. ◽  
Vishnuvardhan Ch. ◽  
Lingesh A. ◽  
Naidu V.G.M. ◽  
Naveen Ch. ◽  
...  
Keyword(s):  
Degradation Products ◽  
In Vitro Cytotoxicity ◽  
Cytotoxicity Assay ◽  
Forced Degradation

Photodegradation kinetics of lodenafil carbonate, structure elucidation of two major degradation products using UPLC-MS/MS and in vitro cytotoxicity

2013 ◽  
Vol 5 (22) ◽  
pp. 6511 ◽  
Author(s):  
Cristiane Franco Codevilla ◽  
Alini Dall Cortivo Lange ◽  
Juliana Maria de Mello Andrade ◽  
Jéferson Segalin ◽  
Pedro Eduardo Fröehlich ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Degradation Products ◽  
In Vitro Cytotoxicity ◽  
Kinetics Of

Delapril and Manidipine Main Degradation Products: LC-UV and LC-ESI-MS Evaluations, Decay Kinetic, and in vitro Cytotoxicity Studies

2015 ◽  
Vol 38 (13) ◽  
pp. 1333-1342 ◽  
Author(s):  
Vítor Todeschini ◽  
Maximiliano da Silva Sangoi ◽  
Gustavo Krumel Goelzer ◽  
Juliana Maria de Mello Andrade ◽  
Nadia Maria Volpato
Keyword(s):  
Degradation Products ◽  
In Vitro Cytotoxicity ◽  
Decay Kinetic ◽  
Esi Ms ◽  
Cytotoxicity Studies

In Vitro Cytotoxicity of Bacterial Cellulose Scaffolds Used for Tissue-engineered Bone

2009 ◽  
Vol 24 (1_suppl) ◽  
pp. 137-145 ◽  
Author(s):  
Y.M. Chen ◽  
Tingfei Xi ◽  
Yudong Zheng ◽  
Tingting Guo ◽  
Jiaquan Hou ◽  
...  
Keyword(s):  
Bacterial Cellulose ◽  
Degradation Products ◽  
Culture Cell ◽  
In Vitro Cytotoxicity ◽  
Reducing Sugar ◽  
Fibroblast Cells ◽  
In Vitro Degradation ◽  
Culture Cell Line ◽  
Potential Applications

The in vitro degradation and cytotoxicity of bacterial cellulose (BC) and its degradation products were studied for potential applications in bone tissue engineering. Emission scanning electron microscope was used to observe the morphology of original materials and their degradation products. The degradation was evaluated by measuring the concentration of reducing sugar by using ultraviolet spectrophotometer. Bone forming osteoblast (OB) cells and infinite culture cell line L929 fibroblasts were used to measure the cytotoxicity of materials using the MTT assay. Both types of cells proliferated normally with the BC and its degradation products with a cytotoxicity graded of 0–1. Nevertheless, the bone-forming target OB cells were more susceptible to cytotoxicity than the infinite culture fibroblast cells L929 fibroblasts. The results indicate that the BC is not very cytotoxic and that tissue functional cells are more suitable for evaluating the cytotoxicity of biomedical materials.

scholarly journals Development of an Acid-Labile Ketal Linked Amphiphilic Block Copolymer Nanoparticles for pH-Triggered Release of Paclitaxel

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1465
Author(s):  
Svetlana Lukáš Petrova ◽  
Eliézer Jäger ◽  
Alessandro Jäger ◽  
Anita Höcherl ◽  
Rafał Konefał ◽  
...  
Keyword(s):  
Delivery System ◽  
Cell Model ◽  
Degradation Products ◽  
Monomethyl Ether ◽  
In Vitro Cytotoxicity ◽  
Triggered Release ◽  
Cytotoxicity Studies ◽  
Endosomal Ph ◽  
Acid Labile

Here, we report on the construction of biodegradable poly(ethylene oxide monomethyl ether) (MPEO)-b-poly(ε-caprolactone) (PCL) nanoparticles (NPs) having acid-labile (acyclic ketal group) linkage at the block junction. In the presence of acidic pH, the nanoassemblies were destabilized as a consequence of cleaving this linkage. The amphiphilic MPEO-b-PCL diblock copolymer self-assembled in PBS solution into regular spherical NPs. The structure of self-assemble and disassemble NPs were characterized in detail by dynamic (DLS), static (SLS) light scattering, small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM). The key of the obtained NPs is using them in a paclitaxel (PTX) delivery system and study their in vitro cytostatic activity in a cancer cell model. The acid-labile ketal linker enabled the disassembly of the NPs in a buffer simulating an acidic environment in endosomal (pH ~5.0 to ~6.0) and lysosomal (pH ~4.0 to ~5.0) cell compartments resulting in the release of paclitaxel (PTX) and formation of neutral degradation products. The in vitro cytotoxicity studies showed that the activity of the drug-loaded NPs was increased compared to the free PTX. The ability of the NPs to release the drug at the endosomal pH with concomitant high cytotoxicity makes them suitable candidates as a drug delivery system for cancer therapy.

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