Fetal Alz-50 Clone 1 (FAC1) Protein Interacts with the Myc-Associated Zinc Finger Protein (ZF87/MAZ) and Alters Its Transcriptional Activity†

Biochemistry ◽  
2000 ◽  
Vol 39 (12) ◽  
pp. 3206-3215 ◽  
Author(s):  
K. L. Jordan-Sciutto ◽  
J. M. Dragich ◽  
J. Caltagarone ◽  
D. J. Hall ◽  
R. Bowser
Keyword(s):  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
Finger Protein

scholarly journals A SWI2/SNF2-type ATPase/helicase protein, mDomino, interacts with myeloid zinc finger protein 2A (MZF-2A) to regulate its transcriptional activity

2003 ◽  
Vol 8 (4) ◽  
pp. 325-339 ◽  
Author(s):  
Hironori Ogawa ◽  
Takeshi Ueda ◽  
Tomohisa Aoyama ◽  
Ami Aronheim ◽  
Shigekazu Nagata ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
Finger Protein ◽  
Myeloid Zinc Finger

The artificial 4-zinc-finger protein Bagly binds human utrophin promoter A at the endogenous chromosomal site and activates transcription

2007 ◽  
Vol 85 (3) ◽  
pp. 358-365 ◽  
Author(s):  
Annalisa Onori ◽  
Agata Desantis ◽  
Serena Buontempo ◽  
Maria Grazia Di Certo ◽  
Maurizio Fanciulli ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
Target Sequence ◽  
Zinc Finger Domain ◽  
Active Chromatin ◽  
Finger Protein ◽  
Chromosomal Site ◽  
Transcription Factor Yy1 ◽  
Test Gene

Our aim is to upregulate the expression of the dystrophin-related gene utrophin in Duchenne muscular dystrophy, in this way complementing the lack of dystrophin function. To achieve utrophin upregulation, we designed and engineered synthetic zinc-inger based transcription factors. We have previously shown that the artificial 3-zinc-finger protein Jazz, fused with the appropriate effector domain, is able to drive the transcription of a test gene from utrophin promoter A. Here we report a novel artificial 4-zinc-finger protein, Bagly, which binds with optimized affinity–specificity to a 12 bp DNA target sequence that is internal to human utrophin promoter A. Bagly was generated adding to Jazz protein an extra-fourth zinc finger, derived from transcription factor YY1. Importantly, the Bagly DNA target sequence is statistically present in the human genome only 210 times, about 60 fewer times than the 9 bp Jazz DNA target sequence. Thanks to its additional zinc-finger domain, Bagly protein shows enhanced transcriptional activity. Moreover, we demonstrated Bagly's effective access and binding to active chromatin in the chromosomal context and its ability to upregulate endogenous utrophin.

scholarly journals ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity

BMB Reports ◽  
2010 ◽  
Vol 43 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Yun Deng ◽  
Bisheng Liu ◽  
Xiongwei Fan ◽  
Yuequn Wang ◽  
Ming Tang ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
C2h2 Zinc Finger ◽  
Finger Protein ◽  
C2h2 Zinc Finger Protein

Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis

2012 ◽  
Vol 363 (1-2) ◽  
pp. 409-417 ◽  
Author(s):  
Fengqin Xu ◽  
Weiping Wang ◽  
Chen Lei ◽  
Qingmei Liu ◽  
Hao Qiu ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
Finger Protein

scholarly journals PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity

2007 ◽  
Vol 39 (4) ◽  
pp. 450-457 ◽  
Author(s):  
Sang-Jin Lee ◽  
Jae-Rin Lee ◽  
Hwa-Sun Hah ◽  
Young-Hoon Kim ◽  
Jin-Hyun Ahn ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
Finger Protein ◽  
Zinc Finger Motifs
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