scholarly journals Cloning and Characterization of a Novel Zinc Finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors

2003 ◽  
Vol 17 (11) ◽  
pp. 2303-2319 ◽  
Author(s):  
Bente Børud ◽  
Gunnar Mellgren ◽  
Johan Lund ◽  
Marit Bakke
Keyword(s):  
Nuclear Receptors ◽  
Zinc Finger ◽  
Transcriptional Activity ◽  
Zinc Finger Protein ◽  
Finger Protein

scholarly journals Single amino acid exchanges in separate domains of the Drosophila serendipity delta zinc finger protein cause embryonic and sex biased lethality.

Genetics ◽  
1992 ◽  
Vol 131 (4) ◽  
pp. 905-916 ◽  
Author(s):  
M Crozatier ◽  
K Kongsuwan ◽  
P Ferrer ◽  
J R Merriam ◽  
J A Lengyel ◽  
...  
Keyword(s):  
Amino Acid ◽  
Dna Binding ◽  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Essential Gene ◽  
Larval Instar ◽  
Single Amino Acid ◽  
Isolation And Characterization ◽  
Finger Protein

Abstract The Drosophila serendipity (sry) delta (delta) zinc finger protein is a sequence-specific DNA binding protein, maternally inherited by the embryo and present in nuclei of transcriptionally active cells throughout fly development. We report here the isolation and characterization of four ethyl methanesulfate-induced zygotic lethal mutations of different strengths in the sry delta gene. For the stronger allele, all of the lethality occurs during late embryogenesis or the first larval instar. In the cases of the three weaker alleles, most of the lethality occurs during pupation; moreover, those adult escapers that emerge are sterile males lacking partially or completely in spermatozoa bundles. Genetic analysis of sry delta thus indicates that it is an essential gene, whose continued expression throughout the life cycle, notably during embryogenesis and pupal stage, is required for viability. Phenotypic analysis of sry delta hemizygote escaper males further suggests that sry delta may be involved in regulation of two different sets of genes: genes required for viability and genes involved in gonadal development. All four sry delta alleles are fully rescued by a wild-type copy of sry delta, but not by an additional copy of the sry beta gene, reinforcing the view that, although structurally related, these two genes exert distinct functions. Molecular characterization of the four sry delta mutations revealed that these mutations correspond to single amino acid replacements in the sry delta protein. Three of these replacements map to the same (third out of seven) zinc finger in the carboxy-terminal DNA binding domain; interestingly, none affects the zinc finger consensus residues. The fourth mutation is located in the NH2-proximal part of the protein, in a domain proposed to be involved in specific protein-protein interactions.

Characterization of a family of Arabidopsis zinc finger protein cDNAs

1995 ◽  
Vol 28 (2) ◽  
pp. 267-279 ◽  
Author(s):  
Brian W. Tague ◽  
Howard M. Goodman
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein

scholarly journals Characterization of a Novel Gene Encoding a Putative Single Zinc-finger Protein,ZIM, Expressed during the Reproductive Phase inArabidopsis thaliana

2000 ◽  
Vol 64 (7) ◽  
pp. 1402-1409 ◽  
Author(s):  
Akiko NISHII ◽  
Miho TAKEMURA ◽  
Hidetomo FUJITA ◽  
Masahito SHIKATA ◽  
Akiho YOKOTA ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Gene Encoding ◽  
Novel Gene ◽  
Finger Protein ◽  
Reproductive Phase

Cloning and Characterization of a Novel p21Cip1/Waf1-Interacting Zinc Finger Protein, Ciz1

1999 ◽  
Vol 264 (2) ◽  
pp. 457-464 ◽  
Author(s):  
Kaoru Mitsui ◽  
Akira Matsumoto ◽  
Satoshi Ohtsuka ◽  
Motoaki Ohtsubo ◽  
Akihiko Yoshimura
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Finger Protein
Sign in / Sign up

Export Citation Format

Share Document