Effect of Geometric Isomerism in Dinuclear Platinum Antitumor Complexes on DNA Interstrand Cross-Linking†

Biochemistry ◽  
1999 ◽  
Vol 38 (34) ◽  
pp. 10997-11005 ◽  
Author(s):  
Jana Kašpárková ◽  
Olga Nováková ◽  
Oldřich Vrána ◽  
Nicholas Farrell ◽  
Viktor Brabec
Keyword(s):  
Cross Linking ◽  
Geometric Isomerism ◽  
Dinuclear Platinum ◽  
Antitumor Complexes

Effects of geometric isomerism in dinuclear platinum antitumor complexes on aquation reactions in the presence of perchlorate, acetate and phosphate

2005 ◽  
Vol 10 (6) ◽  
pp. 652-666 ◽  
Author(s):  
Junyong Zhang ◽  
Donald S. Thomas ◽  
Murray S. Davies ◽  
Susan J. Berners-Price ◽  
Nicholas Farrell
Keyword(s):  
Geometric Isomerism ◽  
Dinuclear Platinum ◽  
Antitumor Complexes

Trifunctional Dinuclear Platinum Complexes as DNA−Protein Cross-Linking Agents†

Biochemistry ◽  
2004 ◽  
Vol 43 (24) ◽  
pp. 7776-7786 ◽  
Author(s):  
Miriam Kloster ◽  
Hana Kostrhunova ◽  
Renata Zaludova ◽  
Jaroslav Malina ◽  
Jana Kasparkova ◽  
...  
Keyword(s):  
Platinum Complexes ◽  
Cross Linking ◽  
Dinuclear Platinum ◽  
Dinuclear Platinum Complexes ◽  
Protein Cross Linking

scholarly journals The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3

2018 ◽  
Vol 54 (22) ◽  
pp. 2788-2791 ◽  
Author(s):  
Wen Zhou ◽  
Mohammad Almeqdadi ◽  
Michael E. Xifaras ◽  
Imogen A. Riddell ◽  
Ömer H. Yilmaz ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Platinum Complex ◽  
Cross Linking ◽  
Geometric Isomerism ◽  
Antitumor Properties

The trans-DDP based phenanthridine Pt(ii) complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.

Influence of Calcium Ions on the Plant Cell Surface: Membrane Fusions and Conformational Changes

1974 ◽  
Vol 32 ◽  
pp. 154-155
Author(s):  
D. James Morré ◽  
Charles E. Bracker ◽  
William J. VanDerWoude
Keyword(s):  
Cell Wall ◽  
Cell Surface ◽  
Conformational Changes ◽  
Calcium Ions ◽  
Surface Membrane ◽  
Carboxyl Groups ◽  
Cross Linking ◽  
Ultrastructural Evidence ◽  
Glycine Max L ◽  
Wall Extensibility

Calcium ions in the concentration range 5-100 mM inhibit auxin-induced cell elongation and wall extensibility of plant stems. Inhibition of wall extensibility requires that the tissue be living; growth inhibition cannot be explained on the basis of cross-linking of carboxyl groups of cell wall uronides by calcium ions. In this study, ultrastructural evidence was sought for an interaction of calcium ions with some component other than the wall at the cell surface of soybean (Glycine max (L.) Merr.) hypocotyls.

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