Mechanism of Transfer of the Methyl Group from (6S)-Methyltetrahydrofolate to the Corrinoid/Iron−Sulfur Protein Catalyzed by the Methyltransferase fromClostridium thermoaceticum:  A Key Step in the Wood−Ljungdahl Pathway of Acetyl-CoA Synthesis†

Javier Seravalli; Shaying Zhao; Stephen W. Ragsdale

doi:10.1021/bi982473c

Mechanism of Transfer of the Methyl Group from (6S)-Methyltetrahydrofolate to the Corrinoid/Iron−Sulfur Protein Catalyzed by the Methyltransferase fromClostridium thermoaceticum: A Key Step in the Wood−Ljungdahl Pathway of Acetyl-CoA Synthesis†

Biochemistry ◽

10.1021/bi982473c ◽

1999 ◽

Vol 38 (18) ◽

pp. 5728-5735 ◽

Cited By ~ 23

Author(s):

Javier Seravalli ◽

Shaying Zhao ◽

Stephen W. Ragsdale

Keyword(s):

Acetyl Coa ◽

Methyl Group ◽

Iron Sulfur ◽

Acetyl Coa Synthesis ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text

Controlled potential enzymology of methyl transfer reactions involved in acetyl-CoA synthesis by CO dehydrogenase and the corrinoid/iron-sulfur protein from Clostridium thermoaceticum.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39743-1 ◽

1990 ◽

Vol 265 (6) ◽

pp. 3124-3133 ◽

Cited By ~ 3

Author(s):

W P Lu ◽

S R Harder ◽

S W Ragsdale

Keyword(s):

Transfer Reactions ◽

Clostridium Thermoaceticum ◽

Co Dehydrogenase ◽

Acetyl Coa ◽

Iron Sulfur ◽

Methyl Transfer ◽

Acetyl Coa Synthesis ◽

Controlled Potential ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text

Binding of Carbon Disulfide to the Site of Acetyl-CoA Synthesis by the Nickel-Iron-Sulfur Protein, Carbon Monoxide Dehydrogenase, from Clostridium thermoaceticum

Biochemistry ◽

10.1021/bi00198a048 ◽

1994 ◽

Vol 33 (32) ◽

pp. 9769-9777 ◽

Cited By ~ 29

Author(s):

Manoj Kumar ◽

Wei-Ping Lu ◽

Stephen W. Ragsdale

Keyword(s):

Carbon Monoxide ◽

Carbon Disulfide ◽

Carbon Monoxide Dehydrogenase ◽

Clostridium Thermoaceticum ◽

Acetyl Coa ◽

Nickel Iron ◽

Iron Sulfur ◽

Acetyl Coa Synthesis ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text

Structural insights into methyltransfer reactions of a corrinoid iron-sulfur protein involved in acetyl-CoA synthesis

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0601420103 ◽

2006 ◽

Vol 103 (39) ◽

pp. 14331-14336 ◽

Cited By ~ 76

Author(s):

T. Svetlitchnaia ◽

V. Svetlitchnyi ◽

O. Meyer ◽

H. Dobbek

Keyword(s):

Acetyl Coa ◽

Iron Sulfur ◽

Acetyl Coa Synthesis ◽

Sulfur Protein ◽

Iron Sulfur Protein ◽

Structural Insights

Download Full-text

Stopped-Flow Kinetics of Methyl Group Transfer between the Corrinoid-Iron-Sulfur Protein and Acetyl-Coenzyme A Synthase fromClostridiumthermoaceticum

Journal of the American Chemical Society ◽

10.1021/ja016676r ◽

2002 ◽

Vol 124 (22) ◽

pp. 6277-6284 ◽

Cited By ~ 36

Author(s):

Xiang Shi Tan ◽

Christopher Sewell ◽

Paul A. Lindahl

Keyword(s):

Stopped Flow ◽

Acetyl Coenzyme A ◽

Methyl Group ◽

Group Transfer ◽

Iron Sulfur ◽

Sulfur Protein ◽

Acetyl Coenzyme A Synthase ◽

Iron Sulfur Protein ◽

Kinetics Of ◽

Methyl Group Transfer

Download Full-text

A Conformational Change in the Methyltransferase fromClostridium thermoaceticumFacilitates the Methyl Transfer from (6S)-Methyltetrahydrofolate to the Corrinoid/Iron−Sulfur Protein in the Acetyl-CoA Pathway†

Biochemistry ◽

10.1021/bi952310d ◽

1996 ◽

Vol 35 (7) ◽

pp. 2476-2481 ◽

Cited By ~ 12

Author(s):

Shaying Zhao ◽

Stephen W. Ragsdale

Keyword(s):

Conformational Change ◽

Acetyl Coa ◽

Iron Sulfur ◽

Methyl Transfer ◽

Sulfur Protein ◽

Acetyl Coa Pathway ◽

Iron Sulfur Protein

Download Full-text

Mechanistic Studies of the Methyltransferase from Clostridium thermoaceticum: Origin of the pH Dependence of the Methyl Group Transfer from Methyl Tetrahydrofolate to the Corrinoid/Iron-Sulfur Protein

Biochemistry ◽

10.1021/bi00046a013 ◽

1995 ◽

Vol 34 (46) ◽

pp. 15075-15083 ◽

Cited By ~ 32

Author(s):

Shaying Zhao ◽

David Lee Roberts ◽

Stephen W. Ragsdale

Keyword(s):

Ph Dependence ◽

Mechanistic Studies ◽

Clostridium Thermoaceticum ◽

Methyl Group ◽

Group Transfer ◽

Iron Sulfur ◽

Sulfur Protein ◽

Iron Sulfur Protein ◽

Methyl Tetrahydrofolate ◽

Methyl Group Transfer

Download Full-text

Faculty Opinions recommendation of The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029526.345457 ◽

2005 ◽

Author(s):

Joan Broderick

Keyword(s):

Protein Assembly ◽

Iron Sulfur ◽

Late Step ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text

Faculty Opinions recommendation of Redox-dependent complex formation by an ATP-dependent activator of the corrinoid/iron-sulfur protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14264957.15779244 ◽

2012 ◽

Author(s):

Rowena Matthews

Keyword(s):

Complex Formation ◽

Iron Sulfur ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text

Faculty Opinions recommendation of Redox-dependent complex formation by an ATP-dependent activator of the corrinoid/iron-sulfur protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14264957.15777402 ◽

2012 ◽

Author(s):

Russ Hille

Keyword(s):

Complex Formation ◽

Iron Sulfur ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text

Primary Structure of a High Potential Iron-Sulfur Protein from the Photosynthetic Bacterium Thiocapsa pfennigii

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)42958-x ◽

1974 ◽

Vol 249 (4) ◽

pp. 1182-1188

Author(s):

Siv M. Tedro ◽

Terrance E. Meyer ◽

Martin D. Kamen

Keyword(s):

Primary Structure ◽

Photosynthetic Bacterium ◽

High Potential ◽

Iron Sulfur ◽

Sulfur Protein ◽

Iron Sulfur Protein

Download Full-text