Spectroscopic Studies on the Interaction of Aristololactam-β-d-Glucoside with DNA and RNA Double and Triple Helices: A Comparative Study†

Biochemistry ◽  
1999 ◽  
Vol 38 (19) ◽  
pp. 6239-6247 ◽  
Author(s):  
A. Ray ◽  
G. Suresh Kumar ◽  
S. Das ◽  
M. Maiti
Keyword(s):  
Comparative Study ◽  
Spectroscopic Studies ◽  
Dna And Rna ◽  
Triple Helices

A Comparative Study of the Hybridization of Phosphoryl Guanidine Oligonucleotides with DNA and RNA

2021 ◽  
Vol 47 (2) ◽  
pp. 461-468
Author(s):  
A. A. Lomzov ◽  
M. S. Kupryushkin ◽  
E. S. Dyudeeva ◽  
D. V. Pyshnyi
Keyword(s):  
Comparative Study ◽  
Dna And Rna

scholarly journals Stability of an RNA•DNA–DNA triple helix depends on base triplet composition and length of the RNA third strand

2019 ◽  
Vol 47 (14) ◽  
pp. 7213-7222 ◽  
Author(s):  
Charlotte N Kunkler ◽  
Jacob P Hulewicz ◽  
Sarah C Hickman ◽  
Matthew C Wang ◽  
Phillip J McCown ◽  
...  
Keyword(s):  
Relative Stability ◽  
Triple Helix ◽  
Multiple Factors ◽  
Dna And Rna ◽  
Helix Formation ◽  
Canonical Base ◽  
Triple Helix Formation ◽  
Triple Helices ◽  
Dna Triple Helix ◽  
The Stability

AbstractRecent studies suggest noncoding RNAs interact with genomic DNA, forming an RNA•DNA–DNA triple helix that regulates gene expression. However, base triplet composition of pyrimidine motif RNA•DNA–DNA triple helices is not well understood beyond the canonical U•A–T and C•G–C base triplets. Using native gel-shift assays, the relative stability of 16 different base triplets at a single position, Z•X–Y (where Z = C, U, A, G and X–Y = A–T, G–C, T–A, C–G), in an RNA•DNA–DNA triple helix was determined. The canonical U•A–T and C•G–C base triplets were the most stable, while three non-canonical base triplets completely disrupted triple-helix formation. We further show that our RNA•DNA–DNA triple helix can tolerate up to two consecutive non-canonical A•G–C base triplets. Additionally, the RNA third strand must be at least 19 nucleotides to form an RNA•DNA–DNA triple helix but increasing the length to 27 nucleotides does not increase stability. The relative stability of 16 different base triplets in DNA•DNA–DNA and RNA•RNA–RNA triple helices was distinctly different from those in RNA•DNA–DNA triple helices, showing that base triplet stability depends on strand composition being DNA and/or RNA. Multiple factors influence the stability of triple helices, emphasizing the importance of experimentally validating formation of computationally predicted triple helices.

Comparative Study of Modification of DNA and RNA by Oligo(2′-O-Methylribonucleotide) Derivatives

1998 ◽  
Vol 17 (9-11) ◽  
pp. 2153-2156
Author(s):  
Z. A. Sergeeva ◽  
A. G. Venyaminova* ◽  
V. F. Zarytova
Keyword(s):  
Comparative Study ◽  
Dna And Rna

Aminoglycoside−Nucleic Acid Interactions:  Remarkable Stabilization of DNA and RNA Triple Helices by Neomycin

2001 ◽  
Vol 123 (23) ◽  
pp. 5385-5395 ◽  
Author(s):  
Dev P. Arya ◽  
R. Lane Coffee ◽  
Bert Willis ◽  
Anna I. Abramovitch
Keyword(s):  
Nucleic Acid ◽  
Dna And Rna ◽  
Triple Helices ◽  
Nucleic Acid Interactions

ChemInform Abstract: Aminoglycoside-Nucleic Acid Interactions: Remarkable Stabilization of DNA and RNA Triple Helices by Neomycin.

ChemInform ◽  
2010 ◽  
Vol 32 (38) ◽  
pp. no-no
Author(s):  
Dev P. Arya ◽  
R. Lane Coffee Jr. ◽  
Bert Willis ◽  
Anna I. Abramovitch
Keyword(s):  
Nucleic Acid ◽  
Dna And Rna ◽  
Triple Helices ◽  
Nucleic Acid Interactions
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