Metal Binding Affinities ofArabidopsisZinc and Copper Transporters: Selectivities Match the Relative, but Not the Absolute, Affinities of their Amino-Terminal Domains,

Biochemistry ◽  
2009 ◽  
Vol 48 (49) ◽  
pp. 11640-11654 ◽  
Author(s):  
Matthias Zimmermann ◽  
Oliver Clarke ◽  
Jacqui M. Gulbis ◽  
David W. Keizer ◽  
Renee S. Jarvis ◽  
...  
Keyword(s):  
Metal Binding ◽  
Binding Affinities ◽  
Amino Terminal ◽  
Copper Transporters ◽  
The Absolute ◽  
Terminal Domains

scholarly journals Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.

1992 ◽  
Vol 267 (12) ◽  
pp. 8437-8442
Author(s):  
W.J. Lee ◽  
H Ma ◽  
E Takano ◽  
H.Q. Yang ◽  
M Hatanaka ◽  
...  
Keyword(s):  
Molecular Diversity ◽  
Exon Skipping ◽  
Amino Terminal ◽  
Terminal Domains

Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification

2013 ◽  
Vol 454 (1) ◽  
pp. 147-156 ◽  
Author(s):  
Nataliya V. Dolgova ◽  
Sergiy Nokhrin ◽  
Corey H. Yu ◽  
Graham N. George ◽  
Oleg Y. Dmitriev
Keyword(s):  
Metal Binding ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Binding Domain ◽  
Binding Motif ◽  
Copper Chaperone ◽  
Copper Binding ◽  
Copper Transporters ◽  
Metal Binding Domain ◽  
Disease Protein

Human copper transporters ATP7B (Wilson's disease protein) and ATP7A (Menkes' disease protein) have been implicated in tumour resistance to cisplatin, a widely used anticancer drug. Cisplatin binds to the copper-binding sites in the N-terminal domain of ATP7B, and this binding may be an essential step of cisplatin detoxification involving copper ATPases. In the present study, we demonstrate that cisplatin and a related platinum drug carboplatin produce the same adduct following reaction with MBD2 [metal-binding domain (repeat) 2], where platinum is bound to the side chains of the cysteine residues in the CxxC copper-binding motif. This suggests the same mechanism for detoxification of both drugs by ATP7B. Platinum can also be transferred to MBD2 from copper chaperone Atox1, which was shown previously to bind cisplatin. Binding of the free cisplatin and reaction with the cisplatin-loaded Atox1 produce the same protein-bound platinum intermediate. Transfer of platinum along the copper-transport pathways in the cell may serve as a mechanism of drug delivery to its target in the cell nucleus, and explain tumour-cell resistance to cisplatin associated with the overexpression of copper transporters ATP7B and ATP7A.

The effect of non-coordinating side chains on the metal binding affinities of peptides of histidine

Polyhedron ◽  
2013 ◽  
Vol 62 ◽  
pp. 7-17 ◽  
Author(s):  
Ildikó Turi ◽  
Daniele Sanna ◽  
Eugenio Garribba ◽  
Giuseppe Pappalardo ◽  
Imre Sóvágó
Keyword(s):  
Metal Binding ◽  
Side Chains ◽  
Binding Affinities

Functional Differences between the Amino-Terminal Domains of Estrogen Receptors α and β

2000 ◽  
Vol 58 (3) ◽  
pp. 584-590 ◽  
Author(s):  
Franck Delaunay ◽  
Katarina Pettersson ◽  
Michel Tujague ◽  
Jan-Åke Gustafsson
Keyword(s):  
Estrogen Receptors ◽  
Amino Terminal ◽  
Functional Differences ◽  
Terminal Domains

A micro-scale method for determining relative metal-binding affinities of proteins

1997 ◽  
Vol 8 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Jens Sommer-Knudsen ◽  
Antony Bacic
Keyword(s):  
Metal Binding ◽  
Binding Affinities ◽  
Micro Scale ◽  
Scale Method

scholarly journals Embryonic chicken cornea and cartilage synthesize type IX collagen molecules with different amino-terminal domains.

1988 ◽  
Vol 85 (20) ◽  
pp. 7496-7500 ◽  
Author(s):  
K. K. Svoboda ◽  
I. Nishimura ◽  
S. P. Sugrue ◽  
Y. Ninomiya ◽  
B. R. Olsen
Keyword(s):  
Amino Terminal ◽  
Embryonic Chicken ◽  
Collagen Molecules ◽  
And Cartilage ◽  
Terminal Domains

Role of the amino-terminal domains of MEKKs in the activation of NFκB and MAPK pathways and in the regulation of cell proliferation and apoptosis

2002 ◽  
Vol 14 (2) ◽  
pp. 123-131 ◽  
Author(s):  
Christelle Bonvin ◽  
Audrey Guillon ◽  
Miguel X van Bemmelen ◽  
Pär Gerwins ◽  
Gary L Johnson ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Amino Terminal ◽  
Mapk Pathways ◽  
Proliferation And Apoptosis ◽  
Terminal Domains
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