Peptide Inhibitors Use Two Related Mechanisms To Alter the Apparent Calcium Affinity of the Sarcoplasmic Reticulum Calcium Pump†

Biochemistry ◽  
2008 ◽  
Vol 47 (36) ◽  
pp. 9522-9530 ◽  
Author(s):  
Michael R. Afara ◽  
Catharine A. Trieber ◽  
Delaine K. Ceholski ◽  
Howard S. Young
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Peptide Inhibitors ◽  
Calcium Pump ◽  
Calcium Affinity ◽  
Sarcoplasmic Reticulum Calcium

Rational Design of Peptide Inhibitors of the Sarcoplasmic Reticulum Calcium Pump†

Biochemistry ◽  
2006 ◽  
Vol 45 (28) ◽  
pp. 8617-8627 ◽  
Author(s):  
Michael R. Afara ◽  
Catharine A. Trieber ◽  
John Paul Glaves ◽  
Howard S. Young
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Rational Design ◽  
Peptide Inhibitors ◽  
Calcium Pump ◽  
Sarcoplasmic Reticulum Calcium

Invariance of Stoichiometry of the Sarcoplasmic Reticulum Calcium Pump at Physiological Calcium Concentrations – a Reevaluation

1985 ◽  
Vol 40 (7-8) ◽  
pp. 571-575 ◽  
Author(s):  
Wilhelm Hasselbach ◽  
Andrea Migala
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Calcium Level ◽  
Calcium Concentration ◽  
Calcium Uptake ◽  
Atp Hydrolysis ◽  
Calcium Pump ◽  
Oxalate Precipitation ◽  
Sarcoplasmic Reticulum Calcium ◽  
Internal Calcium ◽  
External Calcium

Abstract The decline of the transport ratio of the sarcoplasmic calcium pump observed in a recent study (A. results from the retardation of calcium oxalate precipitation at low calcium/protein ratios. The prevailing high internal calcium level supports a rapid calcium backflux and a compensatory ATP hydrolysis during net calcium uptake which reduces the transport ratio. Yet, the determined calcium back­ flux does not fully account for the decline of the transport ratio. A supposed modulation of the stoichiometry of the pump by external calcium (0.1 μм) is at variance with results of previous studies showing a constant transport ratio of two in the same calcium concentration range.

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