Characterization of the Heptad Repeat Regions, HR1 and HR2, and Design of a Fusion Core Structure Model of the Spike Protein from Severe Acute Respiratory Syndrome (SARS) Coronavirus†

Biochemistry ◽  
2004 ◽  
Vol 43 (44) ◽  
pp. 14064-14071 ◽  
Author(s):  
Yanhui Xu ◽  
Jieqing Zhu ◽  
Yiwei Liu ◽  
Zhiyong Lou ◽  
Fang Yuan ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Core Structure ◽  
Spike Protein ◽  
Heptad Repeat ◽  
Structure Model ◽  
Sars Coronavirus

A Trimerizing GxxxG Motif Is Uniquely Inserted in the Severe Acute Respiratory Syndrome (SARS) Coronavirus Spike Protein Transmembrane Domain†

Biochemistry ◽  
2006 ◽  
Vol 45 (38) ◽  
pp. 11349-11356 ◽  
Author(s):  
Eyal Arbely ◽  
Zvi Granot ◽  
Itamar Kass ◽  
Joseph Orly ◽  
Isaiah T. Arkin
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Transmembrane Domain ◽  
Spike Protein ◽  
Sars Coronavirus ◽  
Gxxxg Motif

scholarly journals Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS

Virology ◽  
2007 ◽  
Vol 363 (2) ◽  
pp. 288-302 ◽  
Author(s):  
Benoît Callendret ◽  
Valérie Lorin ◽  
Pierre Charneau ◽  
Philippe Marianneau ◽  
Hugues Contamin ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Dna Vaccines ◽  
Protective Efficacy ◽  
Viral Rna ◽  
Spike Protein ◽  
Sars Coronavirus ◽  
Rna Export

scholarly journals Immunological Characterization of the Spike Protein of the Severe Acute Respiratory Syndrome Coronavirus

2004 ◽  
Vol 42 (4) ◽  
pp. 1570-1576 ◽  
Author(s):  
L. Lu ◽  
I. Manopo ◽  
B. P. Leung ◽  
H. H. Chng ◽  
A. E. Ling ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Spike Protein ◽  
Immunological Characterization

scholarly journals Recombinant Protein-Based Assays for Detection of Antibodies to Severe Acute Respiratory Syndrome Coronavirus Spike and Nucleocapsid Proteins

2007 ◽  
Vol 14 (3) ◽  
pp. 331-333 ◽  
Author(s):  
Lia M. Haynes ◽  
Congrong Miao ◽  
Jennifer L. Harcourt ◽  
Joel M. Montgomery ◽  
Mai Quynh Le ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Recombinant Protein ◽  
Sensitivity And Specificity ◽  
Immunoglobulin G ◽  
High Sensitivity ◽  
Kinetic Studies ◽  
Spike Protein ◽  
Sars Coronavirus ◽  
Nucleocapsid Proteins

ABSTRACT Recombinant severe acute respiratory syndrome (SARS) nucleocapsid and spike protein-based immunoglobulin G immunoassays were developed and evaluated. Our assays demonstrated high sensitivity and specificity to the SARS coronavirus in sera collected from patients as late as 2 years postonset of symptoms. These assays will be useful not only for routine SARS coronavirus diagnostics but also for epidemiological and antibody kinetic studies.

scholarly journals Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides

2004 ◽  
Vol 101 (22) ◽  
pp. 8455-8460 ◽  
Author(s):  
B. J. Bosch ◽  
B. E. E. Martina ◽  
R. van der Zee ◽  
J. Lepault ◽  
B. J. Haijema ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Spike Protein ◽  
Heptad Repeat ◽  
Infection Inhibition

scholarly journals Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis

Chemotherapy ◽  
2021 ◽  
pp. 1-5
Author(s):  
Domenico Benvenuto ◽  
Francesca Benedetti ◽  
Ayse Banu Demir ◽  
Massimo Ciccozzi ◽  
Davide Zella
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Vaccine Efficacy ◽  
Spike Protein ◽  
Enveloped Virus ◽  
Whole Genomes ◽  
The World ◽  
The Impact

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths. Objective: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy. Methods: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID. Results: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein. Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.

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