Structural Dynamics of Myoglobin:  Effect of Internal Cavities on Ligand Migration and Binding†

Biochemistry ◽  
2003 ◽  
Vol 42 (32) ◽  
pp. 9647-9658 ◽  
Author(s):  
Karin Nienhaus ◽  
Pengchi Deng ◽  
Jan M. Kriegl ◽  
G. Ulrich Nienhaus
Keyword(s):  
Structural Dynamics ◽  
Internal Cavities ◽  
Ligand Migration

The effect of protein internal cavities on ligand migration and binding in myoglobin

Micron ◽  
2004 ◽  
Vol 35 (1-2) ◽  
pp. 67-69 ◽  
Author(s):  
Karin Nienhaus ◽  
Gerd U Nienhaus
Keyword(s):  
Internal Cavities ◽  
Ligand Migration

Structural dynamics of myoglobin: an infrared kinetic study of ligand migration in mutants YQR and YQRF

2004 ◽  
Vol 109 (1) ◽  
pp. 41-58 ◽  
Author(s):  
Don C. Lamb ◽  
Alessandro Arcovito ◽  
Karin Nienhaus ◽  
Oleksandr Minkow ◽  
Federica Draghi ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Structural Dynamics ◽  
Ligand Migration

scholarly journals Effect of Occluded Ligand Migration on the Kinetics and Structural Dynamics of Homodimeric Hemoglobin

2020 ◽  
Vol 124 (8) ◽  
pp. 1550-1556
Author(s):  
Hanui Kim ◽  
Jong Goo Kim ◽  
Srinivasan Muniyappan ◽  
Tae Wu Kim ◽  
Sang Jin Lee ◽  
...  
Keyword(s):  
Structural Dynamics ◽  
Ligand Migration

scholarly journals Impact of azole drugs on energetics, kinetics, and ligand migration pathways of CO photo-dissociation in bacterial flavohemoglobins

RSC Advances ◽  
2020 ◽  
Vol 10 (30) ◽  
pp. 17930-17941
Author(s):  
David Butcher ◽  
Myriam Moussaoui ◽  
Laura Baciou ◽  
Jaroslava Miksovska
Keyword(s):  
Structural Dynamics ◽  
Ligand Migration ◽  
Migration Pathways

Impact of ketoconalzole and miconazole on structural dynamics of flavohemoglobin.

scholarly journals Visualizing breathing motion of internal cavities in concert with ligand migration in myoglobin

2009 ◽  
Vol 106 (8) ◽  
pp. 2612-2616 ◽  
Author(s):  
Ayana Tomita ◽  
Tokushi Sato ◽  
Kouhei Ichiyanagi ◽  
Shunsuke Nozawa ◽  
Hirohiko Ichikawa ◽  
...  
Keyword(s):  
Breathing Motion ◽  
Internal Cavities ◽  
Ligand Migration

Structural dynamics of P-type ATPase ion pumps

2019 ◽  
Vol 47 (5) ◽  
pp. 1247-1257 ◽  
Author(s):  
Mateusz Dyla ◽  
Sara Basse Hansen ◽  
Poul Nissen ◽  
Magnus Kjaergaard
Keyword(s):  
Structural Dynamics ◽  
Single Molecule ◽  
New Technologies ◽  
Atp Hydrolysis ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Time Resolved ◽  
Dynamics Simulations ◽  
Types Of Information ◽  
P Type

Abstract P-type ATPases transport ions across biological membranes against concentration gradients and are essential for all cells. They use the energy from ATP hydrolysis to propel large intramolecular movements, which drive vectorial transport of ions. Tight coordination of the motions of the pump is required to couple the two spatially distant processes of ion binding and ATP hydrolysis. Here, we review our current understanding of the structural dynamics of P-type ATPases, focusing primarily on Ca2+ pumps. We integrate different types of information that report on structural dynamics, primarily time-resolved fluorescence experiments including single-molecule Förster resonance energy transfer and molecular dynamics simulations, and interpret them in the framework provided by the numerous crystal structures of sarco/endoplasmic reticulum Ca2+-ATPase. We discuss the challenges in characterizing the dynamics of membrane pumps, and the likely impact of new technologies on the field.

Structural dynamics of free molecules and condensed matter

2018 ◽  
Vol 190 (02) ◽  
pp. 113-136
Author(s):  
Sergei A. Aseyev ◽  
A.S. Akhmanov ◽  
G.V. Girichev ◽  
Anatoly A. Ischenko ◽  
Igor V. Kochikov ◽  
...  
Keyword(s):  
Structural Dynamics ◽  
Condensed Matter ◽  
Free Molecules
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