Breaking Symmetry:  Mutations Engineered into R67 Dihydrofolate Reductase, aD2Symmetric Homotetramer Possessing a Single Active Site Pore†

Biochemistry ◽  
2002 ◽  
Vol 41 (52) ◽  
pp. 15664-15675 ◽  
Author(s):  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Arnold M. Saxton ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site ◽  
R67 Dihydrofolate Reductase ◽  
Breaking Symmetry

scholarly journals Asymmetric mutations in the tetrameric R67 dihydrofolate reductase reveal high tolerance to active-site substitutions

2014 ◽  
Vol 24 (4) ◽  
pp. 495-507 ◽  
Author(s):  
Maximilian C. C. J. C. Ebert ◽  
Krista L. Morley ◽  
Jordan P. Volpato ◽  
Andreea R. Schmitzer ◽  
Joelle N. Pelletier
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site ◽  
High Tolerance ◽  
R67 Dihydrofolate Reductase

Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase†

Biochemistry ◽  
2003 ◽  
Vol 42 (36) ◽  
pp. 10569-10578 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
J. Bradley Hamilton ◽  
Elizabeth E. Howell
Keyword(s):  
Ligand Binding ◽  
Dihydrofolate Reductase ◽  
Ionic Interactions ◽  
R67 Dihydrofolate Reductase

Does R67 Dihydrofolate Reductase Possess a Proton Donor?

1993 ◽  
pp. 493-498 ◽  
Author(s):  
Janel C. Holland ◽  
Charles E. Linn ◽  
Enrico DiGiammarino ◽  
Robert Nichols ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
Proton Donor ◽  
R67 Dihydrofolate Reductase

scholarly journals Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations

2004 ◽  
Vol 279 (45) ◽  
pp. 46995-47002 ◽  
Author(s):  
Stephanie N. Hicks ◽  
R. Derike Smiley ◽  
Lori G. Stinnett ◽  
Kenneth H. Minor ◽  
Elizabeth E. Howell
Keyword(s):  
Dihydrofolate Reductase ◽  
R67 Dihydrofolate Reductase
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