Maintenance of α-Helical Structures by Phenyl Rings in the Active-Site Tyrosine Triad Contributes to Catalysis and Stability of Ketosteroid Isomerase fromPseudomonas putidaBiotype B†

Biochemistry ◽  
2001 ◽  
Vol 40 (45) ◽  
pp. 13529-13537 ◽  
Author(s):  
Gyu Hyun Nam ◽  
Do Soo Jang ◽  
Sun-Shin Cha ◽  
Tae-Hee Lee ◽  
Do-Hyung Kim ◽  
...  
Keyword(s):  
Active Site ◽  
Helical Structures ◽  
Ketosteroid Isomerase ◽  
Phenyl Rings ◽  
Active Site Tyrosine

scholarly journals Mass spectrometric studies of a modified active-site tetrapeptide from delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni.

1982 ◽  
Vol 257 (21) ◽  
pp. 12589-12593
Author(s):  
T M Penning ◽  
D N Heller ◽  
T M Balasubramanian ◽  
C C Fenselau ◽  
P Talalay
Keyword(s):  
Active Site ◽  
Mass Spectrometric ◽  
Ketosteroid Isomerase ◽  
Pseudomonas Testosteroni

scholarly journals Globally Optimized Molecular Embeddings for Dynamic Reaction Solvate Shell Optimization and Active Site Design

2021 ◽  
Author(s):  
Dominik M. Behrens ◽  
Bernd Hartke
Keyword(s):  
Global Optimization ◽  
Active Site ◽  
Solvate Shell ◽  
Dynamic Reaction ◽  
Ketosteroid Isomerase ◽  
Recent Interest ◽  
Site Design ◽  
Shell Optimization

AbstractWe demonstrate how a full QM/MM derivatization of the recently developed GOCAT model can be utilized in the global optimization of molecular embeddings. To this end, we provide two distinct examples: An $$\text {S}_\text {N}2$$ S N 2 reaction, and one enzymatic example of recent interest, the ketosteroid isomerase. These serve us to highlight the advantages of such an approach and sketch the roadmap for further improvements.

Stabilization of Radical Intermediates by an Active-Site Tyrosine Residue in Methylmalonyl-CoA Mutase†,‡

Biochemistry ◽  
1998 ◽  
Vol 37 (41) ◽  
pp. 14386-14393 ◽  
Author(s):  
Nicolas H. Thomä ◽  
Thomas W. Meier ◽  
Philip R. Evans ◽  
Peter F. Leadlay
Keyword(s):  
Active Site ◽  
Tyrosine Residue ◽  
Radical Intermediates ◽  
Active Site Tyrosine

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

2015 ◽  
Vol 10 (4) ◽  
pp. 1094-1098 ◽  
Author(s):  
Erik C. Hett ◽  
Hua Xu ◽  
Kieran F. Geoghegan ◽  
Ariamala Gopalsamy ◽  
Robert E. Kyne ◽  
...  
Keyword(s):  
Active Site ◽  
Tyrosine Residues ◽  
Active Site Tyrosine ◽  
Sulfonyl Fluoride
Sign in / Sign up

Export Citation Format

Share Document