Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of .DELTA.5-3-ketosteroid isomerase by steroid binding

Biochemistry ◽  
1995 ◽  
Vol 34 (19) ◽  
pp. 6562-6572 ◽  
Author(s):  
Qinjian Zhao ◽  
Yaw-Kuen Li ◽  
Albert S. Mildvan ◽  
Paul Talalay
Keyword(s):  
Active Site ◽  
Tyrosine Residue ◽  
Ketosteroid Isomerase ◽  
Spectroscopic Evidence ◽  
Steroid Binding ◽  
Active Site Tyrosine

Stabilization of Radical Intermediates by an Active-Site Tyrosine Residue in Methylmalonyl-CoA Mutase†,‡

Biochemistry ◽  
1998 ◽  
Vol 37 (41) ◽  
pp. 14386-14393 ◽  
Author(s):  
Nicolas H. Thomä ◽  
Thomas W. Meier ◽  
Philip R. Evans ◽  
Peter F. Leadlay
Keyword(s):  
Active Site ◽  
Tyrosine Residue ◽  
Radical Intermediates ◽  
Active Site Tyrosine

scholarly journals A Conserved Active Site Tyrosine Residue of Proline Dehydrogenase Helps Enforce the Preference for Proline over Hydroxyproline as the Substrate†‡

Biochemistry ◽  
2009 ◽  
Vol 48 (5) ◽  
pp. 951-959 ◽  
Author(s):  
Elizabeth L. Ostrander ◽  
John D. Larson ◽  
Jonathan P. Schuermann ◽  
John J. Tanner
Keyword(s):  
Active Site ◽  
Tyrosine Residue ◽  
Proline Dehydrogenase ◽  
Active Site Tyrosine

scholarly journals Mass spectrometric studies of a modified active-site tetrapeptide from delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni.

1982 ◽  
Vol 257 (21) ◽  
pp. 12589-12593
Author(s):  
T M Penning ◽  
D N Heller ◽  
T M Balasubramanian ◽  
C C Fenselau ◽  
P Talalay
Keyword(s):  
Active Site ◽  
Mass Spectrometric ◽  
Ketosteroid Isomerase ◽  
Pseudomonas Testosteroni

scholarly journals Globally Optimized Molecular Embeddings for Dynamic Reaction Solvate Shell Optimization and Active Site Design

2021 ◽  
Author(s):  
Dominik M. Behrens ◽  
Bernd Hartke
Keyword(s):  
Global Optimization ◽  
Active Site ◽  
Solvate Shell ◽  
Dynamic Reaction ◽  
Ketosteroid Isomerase ◽  
Recent Interest ◽  
Site Design ◽  
Shell Optimization

AbstractWe demonstrate how a full QM/MM derivatization of the recently developed GOCAT model can be utilized in the global optimization of molecular embeddings. To this end, we provide two distinct examples: An $$\text {S}_\text {N}2$$ S N 2 reaction, and one enzymatic example of recent interest, the ketosteroid isomerase. These serve us to highlight the advantages of such an approach and sketch the roadmap for further improvements.

scholarly journals Structural evidence for a reaction intermediate mimic in the active site of a sulfite dehydrogenase

2020 ◽  
Vol 56 (68) ◽  
pp. 9850-9853
Author(s):  
Ahmed Djeghader ◽  
Melanie Rossotti ◽  
Saleh Abdulkarim ◽  
Frédéric Biaso ◽  
Guillaume Gerbaud ◽  
...  
Keyword(s):  
Active Site ◽  
Spectroscopic Evidence ◽  
Reaction Intermediate

We provide structural and spectroscopic evidence for a molybdenum–phosphate adduct mimicking a proposed reaction intermediate in the active site of a prokaryotic sulfite oxidizing enzyme.

Sign in / Sign up

Export Citation Format

Share Document