The Capsular Polysaccharide of Pneumococcus Type XII, SXII*

Biochemistry ◽  
1966 ◽  
Vol 5 (9) ◽  
pp. 3066-3072 ◽  
Author(s):  
J. A. Cifonelli ◽  
P. Rebers ◽  
M. B. Perry ◽  
J. K. N. Jones
Keyword(s):  
Capsular Polysaccharide ◽  
Pneumococcus Type

scholarly journals Synthesis of a conjugate vaccine composed of pneumococcus type 14 capsular polysaccharide bound to pertussis toxin.

1992 ◽  
Vol 60 (9) ◽  
pp. 3528-3532 ◽  
Author(s):  
R Schneerson ◽  
L Levi ◽  
J B Robbins ◽  
D M Bryla ◽  
G Schiffman ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Pertussis Toxin ◽  
Capsular Polysaccharide ◽  
Pneumococcus Type

scholarly journals THE CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE IX

1966 ◽  
Vol 123 (5) ◽  
pp. 913-920 ◽  
Author(s):  
C. V. N. Rao ◽  
Michael Heidelberger
Keyword(s):  
Capsular Polysaccharide ◽  
Glucuronic Acid ◽  
The Other ◽  
Complete Hydrolysis ◽  
Serological Data ◽  
Pneumococcus Type

The capsular polysaccharide of Type IX pneumococcus contains D-glucose, N-acetyl-D-glucosamine, and D-glucuronic acid. Complete hydrolysis is difficult. All of the N-acetylglucosamine is resistant to oxidation by periodate, but the other two sugars are degraded in part. Chemical and quantitative serological data are consistent with the linkage of two D-glucose residues 1 → 4, as in maltose; others may be linked 1 → 3. Part, at least, of the glucuronic acid and N-acetylglucosamine is linked to glucose.

Structural determination of the capsular polysaccharide of Streptococcuspneumoniae type-19 (19F)

1980 ◽  
Vol 58 (11) ◽  
pp. 1069-1074 ◽  
Author(s):  
Harold J. Jennings ◽  
Karl-Gunnar Rosell ◽  
Dennis J. Carlo
Keyword(s):  
Nmr Spectroscopy ◽  
Capsular Polysaccharide ◽  
Molar Ratio ◽  
Structural Determination ◽  
Pneumococcus Type

The structure of the Pneumococcus type-19 (19F) capsular polysaccharide has been reinvestigated using nmr spectroscopy. It is composed of residues of 2-acetamido-2-deoxy-D-mannose, D-glucose, L-rhamnose, and phosphate in the molar ratio of 1:1:1:1. The polysaccharide is linear and is composed of the above components in a repeating unit of the following structure:→ 4)-β-D-ManNAcp-(1 → 4)-α-D-Glcp-(1→ 2)-α-L-Rhap-(1-PO4−)→.

Mutation in Pneumococcus Type III Affecting Multiple Cistrons Concerned with the Synthesis of Capsular Polysaccharide

1968 ◽  
Vol 96 (4) ◽  
pp. 1099-1102 ◽  
Author(s):  
Harriet P. Bernheimer ◽  
Ingbritt E. Wermundsen ◽  
Robert Austrian
Keyword(s):  
Capsular Polysaccharide ◽  
Type Iii ◽  
Pneumococcus Type

scholarly journals STEPWISE INTRATYPE TRANSFORMATION OF PNEUMOCOCCUS FROM R TO S BY WAY OF A VARIANT INTERMEDIATE IN CAPSULAR POLYSACCHARIDE PRODUCTION

1947 ◽  
Vol 86 (6) ◽  
pp. 439-452 ◽  
Author(s):  
Colin M. MacLeod ◽  
Marjorie R. Krauss
Keyword(s):  
Capsular Polysaccharide ◽  
Large Concentration ◽  
Type Ii ◽  
Surface Component ◽  
Polysaccharide Production ◽  
Massive Growth ◽  
Rough Strain ◽  
Pneumococcus Type

1. A variant intermediate between the classical R and S forms has been isolated by selective procedures from a rough strain of pneumococcus originally derived from Type II S. 2. The intermediate variant D39/Int53 is avirulent for mice, forms rough colonies, and does not possess a demonstrable capsule. However, it synthesizes SSSII which is immunologically indistinguishable from that produced by fully encapsulated pneumococcus Type II, though in much smaller amount. The polysaccharide is present as a surface component and as it exists in the cell is highly antigenic for rabbits. 3. An extract of the intermediate variant causes the transformation in vitro of an R strain into a variant resembling the intermediate in SSSII production but without any apparent alteration in the colonial characteristics of the R variant. 4. The intermediate variant is convertible in vivo, into a fully encapsulated strain of pneumococcus Type II. Transformation of the intermediate to a heterologous type of pneumococcus (Type III) was unsuccessful. 5. A method is described for the preparation of transforming extracts of pneumococci utilizing the massive growth of the organisms obtained in the presence of a large concentration of glucose.

Sign in / Sign up

Export Citation Format

Share Document