Utilization of volatile fatty acids in ruminants. III. Comparison of mitochondrial acyl coenzyme A synthetase activity and substrate specificity in different tissues

Biochemistry ◽  
1969 ◽  
Vol 8 (7) ◽  
pp. 2966-2969 ◽  
Author(s):  
Robert Merold Cook ◽  
Su-Chin C. Liu ◽  
Shahida Quraishi
Keyword(s):  
Fatty Acids ◽  
Substrate Specificity ◽  
Volatile Fatty Acids ◽  
Coenzyme A ◽  
Synthetase Activity ◽  
Acyl Coenzyme A ◽  
Different Tissues

scholarly journals Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine.

1994 ◽  
Vol 103 (3) ◽  
pp. 471-486 ◽  
Author(s):  
S Petrou ◽  
R W Ordway ◽  
J A Hamilton ◽  
J V Walsh ◽  
J J Singer
Keyword(s):  
Fatty Acids ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Coenzyme A ◽  
Muscle Cells ◽  
K Channel ◽  
Channel Activity ◽  
Naturally Occurring ◽  
Acyl Coenzyme A ◽  
Long Chain

We determined the structural features necessary for fatty acids to exert their action on K+ channels of gastric smooth muscle cells. Examination of the effects of a variety of synthetic and naturally occurring lipid compounds on K+ channel activity in cell-attached and excised membrane patches revealed that negatively charged analogs of medium to long chain fatty acids (but not short chain analogs) as well as certain other negatively charged lipids activate the channels. In contrast, positively charged, medium to long chain analogs suppress activity, and neutral analogs are without effect. The key requirements for effective compounds seem to be a sufficiently hydrophobic domain and the presence of a charged group. Furthermore, those negatively charged compounds unable to "flip" across the bilayer are effective only when applied at the cytosolic surface of the membrane, suggesting that the site of fatty acid action is also located there. Finally, because some of the effective compounds, for example, the fatty acids themselves, lysophosphatidate, acyl Coenzyme A, and sphingosine, are naturally occurring substances and can be liberated by agonist-activated or metabolic enzymes, they may act as second messengers targeting ion channels.

scholarly journals Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana

2008 ◽  
Vol 59 (2) ◽  
pp. 403-419 ◽  
Author(s):  
Lucie Kienow ◽  
Katja Schneider ◽  
Michael Bartsch ◽  
Hans-Peter Stuible ◽  
Hua Weng ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Functional Analysis ◽  
Arabidopsis Thaliana ◽  
Coenzyme A ◽  
Acyl Coenzyme A

scholarly journals Long-Chain Acyl–Coenzyme A Esters and Fatty Acids Directly Link Metabolism to KATPChannels in the Heart

2001 ◽  
Vol 88 (9) ◽  
pp. 918-924 ◽  
Author(s):  
Gong Xin Liu ◽  
Peter J. Hanley ◽  
John Ray ◽  
ürgen Daut;
Keyword(s):  
Fatty Acids ◽  
Coenzyme A ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Coenzyme A Esters ◽  
Long Chain

Presence and Properties of Acyl Coenzyme A Synthetase for Medium-Chain Fatty Acids in Rat Intestinal Mucosa

Digestion ◽  
1992 ◽  
Vol 51 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Y. Ohkubo ◽  
S. Mori ◽  
Y. Ishikawa ◽  
K. Shirai ◽  
Y. Saito ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Intestinal Mucosa ◽  
Coenzyme A ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Acyl Coenzyme A ◽  
Chain Fatty Acids
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