Presence and Properties of Acyl Coenzyme A Synthetase for Medium-Chain Fatty Acids in Rat Intestinal Mucosa

Digestion ◽  
1992 ◽  
Vol 51 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Y. Ohkubo ◽  
S. Mori ◽  
Y. Ishikawa ◽  
K. Shirai ◽  
Y. Saito ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Intestinal Mucosa ◽  
Coenzyme A ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Acyl Coenzyme A ◽  
Chain Fatty Acids

Sudden Child Death and `Healthy' Affected Family Members With Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1052-1057
Author(s):  
Marinus Duran ◽  
Marchinus Hofkamp ◽  
William J. Rhead ◽  
Jean-Marie Saudubray ◽  
Sybe K. Wadman
Keyword(s):  
Fatty Acids ◽  
Coenzyme A ◽  
Family Members ◽  
Reye Syndrome ◽  
Dicarboxylic Aciduria ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Chain Fatty Acids

A family is described in which the father and three (and probably all four) of his children had a decreased capacity for the oxidation of medium-chain fatty acids. One of the children suddenly died at the age of 16 months following an episode of a rapidly deteriorating Reye syndrome-like illness with hypoketotic hypoglycemia and dicarboxylic aciduria, but without any previous alarming symptoms. The eldest sibling had died at the age of 19 months under similar conditions. The other family members had always been healthy. On fasting, all affected family members accumulated in their plasma the medium-chain fatty acids octanoic, decanoic, and cis-4-decenoic acids. Their urinary organic acid excretion profile could be characterized as "dicarboxylic aciduria." A deficiency of medium-chain acyl-coenzyme A dehydrogenase was demonstrated in a postmortem liver sample of the index patient. Cultured fibroblasts from the father and the two healthy children had a decreased rate of [14C]octanoate oxidation. It is suggested that a deficiency of medium-chain acyl-coenzyme A dehydrogenase may lead to a life-threatening illness when other complicating factors such as diarrhea and vomiting result in an abnormal depletion of the body's glycogen stores. Careful monitoring of at-risk patients during a minor illness is necessary.

Enhanced Bioavailability of Curcumin Nanoemulsions Stabilized with Phosphatidylcholine Modified with Medium Chain Fatty Acids

2017 ◽  
Vol 14 (3) ◽  
pp. 377-385 ◽  
Author(s):  
Angelica A. Ochoa-Flores ◽  
Josafat A. Hernández-Becerra ◽  
Adriana Cavazos-Garduño ◽  
Ida Soto-Rodríguez ◽  
Maria Guadalupe Sanchez-Otero ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Chain Fatty Acids

scholarly journals Effects of ketogenic diet containing medium-chain fatty acids on serum inflammatory factor and mTOR signaling pathway in rats

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Huan Liu ◽  
Jingwei Huang ◽  
Hui Liu ◽  
Feng Li ◽  
Quansheng Peng ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Caloric Restriction ◽  
Ketogenic Diet ◽  
Mtor Pathway ◽  
Inflammatory Factor ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Sd Rats ◽  
Anti Inflammatory ◽  
Chain Fatty Acids

Abstract Background The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats. Results Male SD rats were assigned to five groups: control diet (C), 20% caloric restriction diet (LC), 20% caloric restriction ketogenic diet (containing MCFAs) (LCKD1), 20% caloric restriction ketogenic diet (LCKD2) and 20% caloric restriction foreign ketogenic diet (LCKD3), and fed for 30 d. LC and KD could significantly reduce the body weight of rats; LC and KD containing MCFAs showed anti-inflammatory effects; KD without MCFAs decreased the concentration of mTOR1, while KD containing MCFAs decreased the expression of AMPK, mtor1 and P70sk. Conclusions KD containing MCFAs showed better effects on the mTOR pathway and anti-inflammation than that without MCFAs.

Determination of free medium-chain fatty acids in beer by stir bar sorptive extraction

2008 ◽  
Vol 1196-1197 ◽  
pp. 96-99 ◽  
Author(s):  
Tomáš Horák ◽  
Jiří Čulík ◽  
Marie Jurková ◽  
Pavel Čejka ◽  
Vladimír Kellner
Keyword(s):  
Fatty Acids ◽  
Stir Bar Sorptive Extraction ◽  
Free Medium ◽  
Medium Chain ◽  
Medium Chain Fatty Acids ◽  
Sorptive Extraction ◽  
Chain Fatty Acids
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