Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

F. Peter Guengerich; W. Morgan Crawford; Philip G. Watanabe

doi:10.1021/bi00590a023

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

Biochemistry ◽

10.1021/bi00590a023 ◽

1979 ◽

Vol 18 (23) ◽

pp. 5177-5182 ◽

Cited By ~ 83

Author(s):

F. Peter Guengerich ◽

W. Morgan Crawford ◽

Philip G. Watanabe

Keyword(s):

Vinyl Chloride ◽

Chloroethylene Oxide ◽

Covalently Bound

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BIODEHALOGENATION: THE METABOLISM OF VINYL CHLORIDE BY METHYLOSINUS TRICHOSPORIUM OB-3b. A SEQUENTIAL OXIDATIVE AND REDUCTIVE PATHWAY THROUGH CHLOROETHYLENE OXIDE

Environmental Toxicology and Chemistry ◽

10.1897/1552-8618(1992)11[749:btmovc]2.0.co;2 ◽

1992 ◽

Vol 11 (6) ◽

pp. 749 ◽

Cited By ~ 1

Author(s):

C.E. Castro ◽

D.M. Riebeth ◽

N.O. Belser

Keyword(s):

Vinyl Chloride ◽

Methylosinus Trichosporium ◽

Chloroethylene Oxide ◽

Reductive Pathway

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Mutation induction in chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde

International Journal of Cancer ◽

10.1002/ijc.2910160414 ◽

1975 ◽

Vol 16 (4) ◽

pp. 639-644 ◽

Cited By ~ 62

Author(s):

Eliezer Huberman ◽

Helmut Bartsch ◽

Leo Sachs

Keyword(s):

Vinyl Chloride ◽

Chinese Hamster ◽

Mutation Induction ◽

V79 Cells ◽

Chinese Hamster V79 Cells ◽

Chloroethylene Oxide

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Biodehalogenation: The metabolism of vinyl chloride byMethylosinus trichosporiumOB-3b. A sequential oxidative and reductive pathway through chloroethylene oxide

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620110604 ◽

1992 ◽

Vol 11 (6) ◽

pp. 749-755 ◽

Cited By ~ 17

Author(s):

C.E. Castro ◽

D.M. Riebeth ◽

N.O. Belser

Keyword(s):

Vinyl Chloride ◽

Chloroethylene Oxide ◽

Reductive Pathway

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Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line

Carcinogenesis ◽

10.1093/carcin/18.1.31 ◽

1997 ◽

Vol 18 (1) ◽

pp. 31-36 ◽

Cited By ~ 15

Author(s):

S. Chiang

Keyword(s):

Vinyl Chloride ◽

Reactive Metabolites ◽

Chloroethylene Oxide

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Poly(vinyl chloride) tubing with covalently bound alkaline phosphatase and alternative approach for investigations of open-tubular bioreactors

Analytical Biochemistry ◽

10.1016/j.ab.2010.01.016 ◽

2010 ◽

Vol 400 (1) ◽

pp. 151-153 ◽

Cited By ~ 14

Author(s):

Beata Rozum ◽

Kamil Gajownik ◽

Łukasz Tymecki ◽

Robert Koncki

Keyword(s):

Alkaline Phosphatase ◽

Vinyl Chloride ◽

Poly Vinyl Chloride ◽

Alternative Approach ◽

Covalently Bound

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The effect of vinyl chloride monomer, chloroethylene oxide and chloracetaldehyde on DNA synthesis in regenerating rat liver

Chemico-Biological Interactions ◽

10.1016/0009-2797(77)90088-6 ◽

1977 ◽

Vol 17 (2) ◽

pp. 239-247 ◽

Cited By ~ 9

Author(s):

Elisabeth A. Border ◽

Ian Webster

Keyword(s):

Dna Synthesis ◽

Vinyl Chloride ◽

Rat Liver ◽

Vinyl Chloride Monomer ◽

Regenerating Rat Liver ◽

Chloroethylene Oxide

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Evidence of chloroethylene oxide being the reactive metabolite of vinyl chloride towards DNA: comparative studies with 2,2′ -dichloro-diethylether

Carcinogenesis ◽

10.1093/carcin/4.11.1483 ◽

1983 ◽

Vol 4 (11) ◽

pp. 1483-1486 ◽

Cited By ~ 30

Author(s):

L.M. Gwinner ◽

R.J. Laib ◽

J.G. Filser ◽

H.M. Bolt

Keyword(s):

Vinyl Chloride ◽

Comparative Studies ◽

Reactive Metabolite ◽

Chloroethylene Oxide

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The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride

Chemico-Biological Interactions ◽

10.1016/0009-2797(76)90041-7 ◽

1976 ◽

Vol 12 (3-4) ◽

pp. 251-263 ◽

Cited By ~ 136

Author(s):

ULF Rannug ◽

Rolf Göthe ◽

Carl Axel Wachtmeister

Keyword(s):

Vinyl Chloride ◽

Chloroacetic Acid ◽

Chloroethylene Oxide

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Vinyl chloride

Chemical & Engineering News ◽

10.1021/cen-v055n033.p011 ◽

1977 ◽

Vol 55 (33) ◽

pp. 11

Keyword(s):

Vinyl Chloride

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Review for "High‐throughput, aseptic production of injectable Tetra‐PEG hydrogel microspheres for delivery of releasable covalently bound drugs"

10.1002/eng2.12213/v1/review4 ◽

2020 ◽

Keyword(s):

High Throughput ◽

Hydrogel Microspheres ◽

Covalently Bound

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