Biodehalogenation: The metabolism of vinyl chloride byMethylosinus trichosporiumOB-3b. A sequential oxidative and reductive pathway through chloroethylene oxide

1992 ◽  
Vol 11 (6) ◽  
pp. 749-755 ◽  
Author(s):  
C.E. Castro ◽  
D.M. Riebeth ◽  
N.O. Belser
Keyword(s):  
Vinyl Chloride ◽  
Chloroethylene Oxide ◽  
Reductive Pathway

Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

Biochemistry ◽  
1979 ◽  
Vol 18 (23) ◽  
pp. 5177-5182 ◽  
Author(s):  
F. Peter Guengerich ◽  
W. Morgan Crawford ◽  
Philip G. Watanabe
Keyword(s):  
Vinyl Chloride ◽  
Chloroethylene Oxide ◽  
Covalently Bound

Certain candidate genes polymorphic variants impact in the development of hypertension when exposed to vinyl chloride

2020 ◽  
pp. 667-667
Author(s):  
I. V. Kudaeva ◽  
O. A. Dyakovich ◽  
I. M. Eshchina
Keyword(s):  
Candidate Genes ◽  
Vinyl Chloride ◽  
Polymorphic Variant ◽  
Apo E ◽  
Genotype C ◽  
Polymorphic Variants

It was found that in persons exposed by vinyl chloride, the risk of hypertension increases six times in carriers of the genotype C/C polymorphic variant of Leu28Pro gene APO E, 9.5 times - in carriers of the genotype T/T polymorphic variant C786T gene eNOS3 and 1.75 times - in carriers of the genotype T/C polymorphic variant Met 235 Thr gene AGT.

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