Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

Biochemistry ◽  
1980 ◽  
Vol 19 (21) ◽  
pp. 4853-4858 ◽  
Author(s):  
Paul F. Cook ◽  
John S. Blanchard ◽  
W. W. Cleland
Keyword(s):  
Isotope Effects ◽  
Equilibrium Constants ◽  
Deuterium Isotope Effects ◽  
Catalyzed Reactions ◽  
Enzyme Catalyzed Reactions

Product dependence of deuterium isotope effects in enzyme-catalyzed reactions

Biochemistry ◽  
1993 ◽  
Vol 32 (7) ◽  
pp. 1795-1802 ◽  
Author(s):  
Paul F. Cook ◽  
Moon Young Yoon ◽  
Shinichi Hara ◽  
G. David McClure
Keyword(s):  
Isotope Effects ◽  
Deuterium Isotope Effects ◽  
Catalyzed Reactions ◽  
Enzyme Catalyzed Reactions

scholarly journals Compare and contrast the reaction coordinate diagrams for chemical reactions and cytoskeletal force generators

2013 ◽  
Vol 24 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Jonathan M. Scholey
Keyword(s):  
Intracellular Transport ◽  
Molecular Mechanisms ◽  
Equilibrium Constants ◽  
Reaction Coordinate ◽  
Simple Chemical ◽  
Interdisciplinary Framework ◽  
Catalyzed Reactions ◽  
Enzyme Catalyzed Reactions ◽  
Compare And Contrast ◽  
Kinetics Of

Reaction coordinate diagrams are used to relate the free energy changes that occur during the progress of chemical processes to the rate and equilibrium constants of the process. Here I briefly review the application of these diagrams to the thermodynamics and kinetics of the generation of force and motion by cytoskeletal motors and polymer ratchets as they mediate intracellular transport, organelle dynamics, cell locomotion, and cell division. To provide a familiar biochemical context for discussing these subcellular force generators, I first review the application of reaction coordinate diagrams to the mechanisms of simple chemical and enzyme-catalyzed reactions. My description of reaction coordinate diagrams of motors and polymer ratchets is simplified relative to the rigorous biophysical treatment found in many of the references that I use and cite, but I hope that the essay provides a valuable qualitative representation of the physical chemical parameters that underlie the generation of force and motility at molecular scales. In any case, I have found that this approach represents a useful interdisciplinary framework for understanding, researching, and teaching the basic molecular mechanisms by which motors contribute to fundamental cell biological processes.

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