Product dependence of deuterium isotope effects in enzyme-catalyzed reactions

Paul F. Cook; Moon Young Yoon; Shinichi Hara; G. David McClure

doi:10.1021/bi00058a013

Product dependence of deuterium isotope effects in enzyme-catalyzed reactions

Biochemistry ◽

10.1021/bi00058a013 ◽

1993 ◽

Vol 32 (7) ◽

pp. 1795-1802 ◽

Cited By ~ 7

Author(s):

Paul F. Cook ◽

Moon Young Yoon ◽

Shinichi Hara ◽

G. David McClure

Keyword(s):

Isotope Effects ◽

Deuterium Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

Biochemistry ◽

10.1021/bi00562a023 ◽

1980 ◽

Vol 19 (21) ◽

pp. 4853-4858 ◽

Cited By ~ 83

Author(s):

Paul F. Cook ◽

John S. Blanchard ◽

W. W. Cleland

Keyword(s):

Isotope Effects ◽

Equilibrium Constants ◽

Deuterium Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Multiple Isotope Effects on Enzyme-Catalyzed Reactions

Annual Review of Biochemistry ◽

10.1146/annurev.bi.58.070189.002113 ◽

1989 ◽

Vol 58 (1) ◽

pp. 377-401 ◽

Cited By ~ 44

Author(s):

M H O'Leary

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Isotope effects on enzyme-catalyzed reactions

Current Biology ◽

10.1016/0960-9822(92)90030-e ◽

1992 ◽

Vol 2 (10) ◽

pp. 548

Author(s):

Vernon E. Anderson

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions

Journal of the American Chemical Society ◽

10.1021/ja00290a052 ◽

1985 ◽

Vol 107 (4) ◽

pp. 1058-1060 ◽

Cited By ~ 42

Author(s):

Judith P. Klinman ◽

Rowena G. Matthews

Keyword(s):

Steady State ◽

Dissociation Constants ◽

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Calculations of intrinsic isotope effects and the detection of tunneling in enzyme-catalyzed reactions

Bioorganic Chemistry ◽

10.1016/0045-2068(90)90026-2 ◽

1990 ◽

Vol 18 (4) ◽

pp. 435-439 ◽

Cited By ~ 6

Author(s):

Dexter B. Northrop ◽

Ronald G. Duggleby

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

Biochemistry ◽

10.1021/bi00510a015 ◽

1981 ◽

Vol 20 (7) ◽

pp. 1805-1816 ◽

Cited By ~ 74

Author(s):

Paul F. Cook ◽

W. W. Cleland

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Kinetic Mechanism ◽

Ph Variation ◽

Ph Dependent ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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[4] Determination of heavy-aton isotope effects on enzyme-catalyzed reactions

Methods in Enzymology - Enzyme Kinetics and Mechanism - Part B: Isotopic Probes and Complex Enzyme Systems ◽

10.1016/s0076-6879(80)64006-3 ◽

1980 ◽

pp. 83-104 ◽

Cited By ~ 80

Author(s):

Marion H. O'Leary

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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The expression of kinetic isotope effects during the time course of enzyme-catalyzed reactions

Bioorganic Chemistry ◽

10.1016/0045-2068(89)90018-7 ◽

1989 ◽

Vol 17 (2) ◽

pp. 177-193 ◽

Cited By ~ 17

Author(s):

Ronald G. Duggleby ◽

Dexter B. Northrop

Keyword(s):

Time Course ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Substrate and pH Dependence of Isotope Effects in Enzyme Catalyzed Reactions

Isotope Effects In Chemistry and Biology ◽

10.1201/9781420028027.ch30 ◽

2005 ◽

pp. 793-810 ◽

Cited By ~ 1

Author(s):

Paul Cook ◽

William Karsten

Keyword(s):

Isotope Effects ◽

Ph Dependence ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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The Application of Transient-State Kinetic Isotope Effects to the Resolution of Mechanisms of Enzyme-Catalyzed Reactions

Molecules ◽

10.3390/molecules18078230 ◽

2013 ◽

Vol 18 (7) ◽

pp. 8230-8242 ◽

Cited By ~ 4

Author(s):

Harvey Fisher

Keyword(s):

Isotope Effects ◽

Transient State ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions ◽

State Kinetic

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