Modulation of neurotransmitter transport by the activity of the action potential sodium ion channel in membrane vesicles from rat brain

Biochemistry ◽  
1980 ◽  
Vol 19 (4) ◽  
pp. 692-697 ◽  
Author(s):  
Baruch I. Kanner
Keyword(s):  
Action Potential ◽  
Ion Channel ◽  
Rat Brain ◽  
Membrane Vesicles ◽  
Sodium Ion ◽  
Neurotransmitter Transport

scholarly journals De Novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study

2009 ◽  
Vol 131 (35) ◽  
pp. 12524-12525 ◽  
Author(s):  
Brian M. Andresen ◽  
J. Du Bois
Keyword(s):  
Ion Channel ◽  
De Novo ◽  
Sodium Ion ◽  
De Novo Synthesis

FURTHER STUDIES ON THE BINDING OF γ-AMINOBUTYRIC ACID BY BRAIN

1967 ◽  
Vol 45 (12) ◽  
pp. 1795-1807 ◽  
Author(s):  
Paula Strasberg ◽  
K. A. C. Elliott
Keyword(s):  
Rat Brain ◽  
Mitochondrial Fraction ◽  
Sodium Ion ◽  
The Other ◽  
Aminobutyric Acid ◽  
Sodium Ions ◽  
Ninhydrin Reaction ◽  
Gaba Content

Factors which can interfere with the paper chromatographic – ninhydrin method for determining γ-aminobutyric acid (GABA) are described. The GABA–ninhydrin reaction does not involve loss of CO2. GABA that is occluded in subcellular particles in plain sucrose homogenates of rat brain does not readily exchange with radioactive GABA in solution. The relevant particles are found mostly in the "mitochondrial fraction". These particles deteriorate with time and manipulations, and tend to lose much of their GABA content. The presence of sodium (but not of potassium, calcium, or magnesium) in the suspending medium allows considerably more GABA to be bound. The extra bound GABA is exchangeable with free labelled GABA. Sodium also promotes some exchange between free and occluded GABA. It is concluded from the present and previous results that in brain in vivo very little GABA exists in a freely diffusing situation. There are two forms of bound GABA. One of these is an occluded or storage form which does not readily exchange with free GABA though exchange is to some extent promoted by sodium ions. The other is a form which occurs only in the presence of sodium ion and is freely exchangeable with GABA in solution.

scholarly journals Prediction of Thorough QT study results using action potential simulations based on ion channel screens

2014 ◽  
Vol 70 (3) ◽  
pp. 246-254 ◽  
Author(s):  
Gary R. Mirams ◽  
Mark R. Davies ◽  
Stephen J. Brough ◽  
Matthew H. Bridgland-Taylor ◽  
Yi Cui ◽  
...  
Keyword(s):  
Action Potential ◽  
Ion Channel ◽  
Thorough Qt Study ◽  
Study Results

Ion channel activity of membrane vesicles released from sea urchin sperm during the acrosome reaction

2004 ◽  
Vol 321 (1) ◽  
pp. 88-93 ◽  
Author(s):  
Joseph R. Schulz ◽  
Jose L. De La Vega-Beltrán ◽  
Carmen Beltrán ◽  
Victor D. Vacquier ◽  
Alberto Darszon
Keyword(s):  
Ion Channel ◽  
Sea Urchin ◽  
Acrosome Reaction ◽  
Membrane Vesicles ◽  
Channel Activity ◽  
Sea Urchin Sperm
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