Molecular mechanisms of binding and single-strand scission of DNA by the antitumor antibiotics saframycins A and C

Biochemistry ◽  
1982 ◽  
Vol 21 (3) ◽  
pp. 419-428 ◽  
Author(s):  
J. William Lown ◽  
Alummoottil V. Joshua ◽  
Jeremy S. Lee
Keyword(s):  
Molecular Mechanisms ◽  
Single Strand ◽  
Antitumor Antibiotics ◽  
Strand Scission

Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA

1976 ◽  
Vol 54 (16) ◽  
pp. 2563-2572 ◽  
Author(s):  
J. William Lown ◽  
Soo-Khoon Sim
Keyword(s):  
Antitumor Activity ◽  
Dna Cleavage ◽  
Single Strand ◽  
Antitumor Antibiotic ◽  
Antitumor Antibiotics ◽  
Substitution Pattern ◽  
Circular Dna ◽  
Strand Scission ◽  
Independent Synthesis ◽  
Selective Catalysis

The syntheses of a group of 2-(o-nitrophenyl)- and 2-(o-aminophenyl)-5,8-quinolinediones which are structurally related to the antitumor antibiotic streptonigrin are described. Ambiguities in the position of required nucleophilic displacements are resolved by independent synthesis. The rates of single strand cleavage of PM2 ccc-DNA (covalently-closed circular-DNA) induced by these compounds are compared, which correlates with antitumor activity. The 2-(o-nitrophenyl) derivatives give consistently more rapid DNA cleavage than the 2-(o-aminophenyl) compounds. The autoxidations of the dihydroxyquinolines are subject to selective catalysis by Cu2+ on. 2-(o-Aminophenyl)-7-amino-6-methoxy-5,6-quinolinedione which has a substitution pattern most closely resembling streptonigrin also closely parallels the rate of scission of DNA of the latter in the presence of NADPH.

scholarly journals Specific cleavage of the terminal protein from the adenovirus 5 DNA under the condition of single-strand scission by nuclease S1

FEBS Letters ◽  
1979 ◽  
Vol 107 (2) ◽  
pp. 355-358 ◽  
Author(s):  
Hiroyoshi Ariga ◽  
Hiroto Shimojo ◽  
So Hidaka ◽  
Kin-ichiro Miura
Keyword(s):  
Single Strand ◽  
Terminal Protein ◽  
Strand Scission ◽  
Nuclease S1 ◽  
Adenovirus 5

Covalent modification and single-strand scission of DNA by a new antitumor antibiotic kapurimycin A3

Biochemistry ◽  
1990 ◽  
Vol 29 (46) ◽  
pp. 10449-10455 ◽  
Author(s):  
Mitsunobu Hara ◽  
Mayumi Yoshida ◽  
Hirofumi Nakano
Keyword(s):  
Covalent Modification ◽  
Single Strand ◽  
Antitumor Antibiotic ◽  
Strand Scission

scholarly journals LET Dependence of DNA Single-Strand Scission in E. coli Bs-1 by Charged Particles

1974 ◽  
Vol 15 (3) ◽  
pp. 148-155
Author(s):  
K. IGARASHI ◽  
F. YATAGAI ◽  
T. TAKAHASHI ◽  
A. MATSUYAMA
Keyword(s):  
Charged Particles ◽  
Single Strand ◽  
Strand Scission ◽  
E Coli
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