Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase

Paul F. Cook; Norman J. Oppenheimer; W. W. Cleland

doi:10.1021/bi00510a016

Secondary deuterium and nitrogen-15 isotope effects in enzyme-catalyzed reactions. Chemical mechanism of liver alcohol dehydrogenase

Biochemistry ◽

10.1021/bi00510a016 ◽

1981 ◽

Vol 20 (7) ◽

pp. 1817-1825 ◽

Cited By ~ 82

Author(s):

Paul F. Cook ◽

Norman J. Oppenheimer ◽

W. W. Cleland

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Chemical Mechanism ◽

Liver Alcohol Dehydrogenase ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

Biochemistry ◽

10.1021/bi00510a015 ◽

1981 ◽

Vol 20 (7) ◽

pp. 1805-1816 ◽

Cited By ~ 74

Author(s):

Paul F. Cook ◽

W. W. Cleland

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Kinetic Mechanism ◽

Ph Variation ◽

Ph Dependent ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Primary deuterium and tritium isotope effects upon V/K in the liver alcohol dehydrogenase reaction with ethanol

Biochemistry ◽

10.1021/bi00523a004 ◽

1981 ◽

Vol 20 (20) ◽

pp. 5662-5669 ◽

Cited By ~ 17

Author(s):

S. E. Damgaard

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Liver Alcohol Dehydrogenase ◽

Dehydrogenase Reaction

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Multiple Isotope Effects on Enzyme-Catalyzed Reactions

Annual Review of Biochemistry ◽

10.1146/annurev.bi.58.070189.002113 ◽

1989 ◽

Vol 58 (1) ◽

pp. 377-401 ◽

Cited By ~ 44

Author(s):

M H O'Leary

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Isotope effects on enzyme-catalyzed reactions

Current Biology ◽

10.1016/0960-9822(92)90030-e ◽

1992 ◽

Vol 2 (10) ◽

pp. 548

Author(s):

Vernon E. Anderson

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions

Journal of the American Chemical Society ◽

10.1021/ja00290a052 ◽

1985 ◽

Vol 107 (4) ◽

pp. 1058-1060 ◽

Cited By ~ 42

Author(s):

Judith P. Klinman ◽

Rowena G. Matthews

Keyword(s):

Steady State ◽

Dissociation Constants ◽

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Calculations of intrinsic isotope effects and the detection of tunneling in enzyme-catalyzed reactions

Bioorganic Chemistry ◽

10.1016/0045-2068(90)90026-2 ◽

1990 ◽

Vol 18 (4) ◽

pp. 435-439 ◽

Cited By ~ 6

Author(s):

Dexter B. Northrop ◽

Ronald G. Duggleby

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Deuterium isotope effects on initial rates of the liver alcohol dehydrogenase reaction. V

Biochemistry ◽

10.1021/bi00747a037 ◽

1973 ◽

Vol 12 (23) ◽

pp. 4802-4805 ◽

Cited By ~ 35

Author(s):

Karen Bush ◽

Vernon J. Shiner ◽

H. R. Mahler

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Liver Alcohol Dehydrogenase ◽

Dehydrogenase Reaction ◽

Deuterium Isotope Effects

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Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

Biochemistry ◽

10.1021/bi00562a023 ◽

1980 ◽

Vol 19 (21) ◽

pp. 4853-4858 ◽

Cited By ~ 83

Author(s):

Paul F. Cook ◽

John S. Blanchard ◽

W. W. Cleland

Keyword(s):

Isotope Effects ◽

Equilibrium Constants ◽

Deuterium Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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[4] Determination of heavy-aton isotope effects on enzyme-catalyzed reactions

Methods in Enzymology - Enzyme Kinetics and Mechanism - Part B: Isotopic Probes and Complex Enzyme Systems ◽

10.1016/s0076-6879(80)64006-3 ◽

1980 ◽

pp. 83-104 ◽

Cited By ~ 80

Author(s):

Marion H. O'Leary

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

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Isotope effects in the binding of NADH to equine liver alcohol dehydrogenase

Biochemistry ◽

10.1021/bi00657a005 ◽

1976 ◽

Vol 15 (12) ◽

pp. 2523-2527 ◽

Cited By ~ 9

Author(s):

Eugene DeJuan ◽

K. B. Taylor

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Liver Alcohol Dehydrogenase

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