Inactivation of monoamine oxidase A by the monoamine oxidase B inactivators 1-phenylcyclopropylamine, 1-benzylcyclopropylamine, and N-cyclopropyl-.alpha.-methylbenzylamine

Biochemistry ◽  
1988 ◽  
Vol 27 (22) ◽  
pp. 8448-8453 ◽  
Author(s):  
Richard B. Silverman ◽  
Charles K. Hiebert
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Monoamine Oxidase B

scholarly journals Oxidation of 3-amino-1-phenylprop-1-enes by monoamine oxidase and their use in a continuous assay of the enzyme

1988 ◽  
Vol 256 (3) ◽  
pp. 911-915 ◽  
Author(s):  
C H Williams ◽  
J Lawson ◽  
F R C Backwell
Keyword(s):  
Monoamine Oxidase ◽  
Absorption Coefficient ◽  
Mitochondrial Protein ◽  
Bovine Liver ◽  
Spectrophotometric Assay ◽  
Monoamine Oxidase A ◽  
Monoamine Oxidase B ◽  
High Absorption Coefficient ◽  
Continuous Assay ◽  
High Absorption

3-Amino-1-phenylprop-1-ene (cinnamylamine) and some derivatives were examined as substrates for monoamine oxidases A and B in mitochondria. All of the amines examined were readily oxidized by monoamine oxidase B but much less readily by monoamine oxidase A. E-Cinnamylamine was found to have Km 0.025 mM and Vmax. 3.9 nmol/min per mg of mitochondrial protein. Corresponding values with monoamine oxidase A were 0.026 mM and 0.85 nmol/min per mg respectively. Despite their different stereochemistry, E- and Z-N-methylcinnamylamines were almost equally effective as substrates for monoamine oxidase B. The characteristic u.v. absorbance and high absorption coefficient of cinnamaldehyde, the product produced by enzymic oxidation of cinnamylamine, is utilized in a sensitive continuous spectrophotometric assay for both enzymes in the rat and for the assay of a purified monoamine oxidase B from bovine liver.

scholarly journals Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

2013 ◽  
Vol 121 (4) ◽  
pp. 379-383 ◽  
Author(s):  
Jasmin Bartl ◽  
Thomas Müller ◽  
Edna Grünblatt ◽  
Manfred Gerlach ◽  
Peter Riederer
Keyword(s):  
Enzyme Activity ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Monoamine Oxidase B ◽  
Inhibitor Treatment

Localization of distinct monoamine oxidase a and monoamine oxidase b cell populations in human brainstem

Neuroscience ◽  
1988 ◽  
Vol 25 (2) ◽  
pp. 439-456 ◽  
Author(s):  
K.N. Westlund ◽  
R.M. Denney ◽  
R.M. Rose ◽  
C.W. Abell
Keyword(s):  
Monoamine Oxidase ◽  
B Cell ◽  
Monoamine Oxidase A ◽  
Cell Populations ◽  
Monoamine Oxidase B
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