βD305A Mutant of Tryptophan Synthase Shows Strongly Perturbed Allosteric Regulation and Substrate Specificity†

Biochemistry ◽  
2001 ◽  
Vol 40 (25) ◽  
pp. 7421-7432 ◽  
Author(s):  
Davide Ferrari ◽  
Li-Hong Yang ◽  
Edith W. Miles ◽  
Michael F. Dunn
Keyword(s):  
Substrate Specificity ◽  
Allosteric Regulation ◽  
Tryptophan Synthase

scholarly journals Functionalized Bilayer Membranes as Artificial Tryptophan Synthase. Characterization of Catalytic Efficiency, Substrate Specificity, and Reaction Selectivity

1990 ◽  
Vol 63 (8) ◽  
pp. 2339-2345 ◽  
Author(s):  
Yukito Murakami ◽  
Jun-ichi Kikuchi ◽  
Yoshio Hisaeda ◽  
Koichiro Nakamura ◽  
Tomoyuki Kitazaki ◽  
...  
Keyword(s):  
Substrate Specificity ◽  
Catalytic Efficiency ◽  
Tryptophan Synthase ◽  
Bilayer Membranes ◽  
Reaction Selectivity

Allosteric Regulation of Tryptophan Synthase Channeling:  The Internal Aldimine Probed bytrans-3-Indole-3‘-acrylate Binding†

Biochemistry ◽  
2007 ◽  
Vol 46 (26) ◽  
pp. 7728-7739 ◽  
Author(s):  
Patricia Casino ◽  
Dimitri Niks ◽  
Huu Ngo ◽  
Peng Pan ◽  
Peter Brzovic ◽  
...  
Keyword(s):  
Allosteric Regulation ◽  
Tryptophan Synthase

On the Role of αThr183 in the Allosteric Regulation and Catalytic Mechanism of Tryptophan Synthase

2002 ◽  
Vol 324 (4) ◽  
pp. 677-690 ◽  
Author(s):  
Victor Kulik ◽  
Michael Weyand ◽  
Ralf Seidel ◽  
Dimitri Niks ◽  
Demet Arac ◽  
...  
Keyword(s):  
Catalytic Mechanism ◽  
Allosteric Regulation ◽  
Tryptophan Synthase

scholarly journals Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3374
Author(s):  
Adam R. Offenbacher ◽  
Theodore R. Holman
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Substrate Specificity ◽  
Cell Signaling ◽  
Small Molecule ◽  
Allosteric Regulation ◽  
Alpha Toxin ◽  
Allosteric Effectors ◽  
Higher Eukaryotes ◽  
Rate Limiting

Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important mediators for cell signaling and inflammation. These reactions are initiated by a C-H activation step that is allosterically regulated in plant and animal enzymes. LOXs from higher eukaryotes are equipped with an N-terminal PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain that has been implicated to bind to small molecule allosteric effectors, which in turn modulate substrate specificity and the rate-limiting steps of catalysis. Herein, the kinetic and structural evidence that describes the allosteric regulation of plant and animal lipoxygenase chemistry by fatty acids and their derivatives are summarized.

scholarly journals Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity

Biochemistry ◽  
2016 ◽  
Vol 55 (51) ◽  
pp. 7043-7046 ◽  
Author(s):  
Andrew R. Buller ◽  
Paul van Roye ◽  
Javier Murciano-Calles ◽  
Frances H. Arnold
Keyword(s):  
Substrate Specificity ◽  
Tryptophan Synthase
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