Circular dichroism spectroscopy of the intermediates that precede the rate-limiting step of the refolding pathway of bovine pancreatic trypsin inhibitor. Relationship of conformation and the refolding pathway

Biochemistry ◽  
1983 ◽  
Vol 22 (10) ◽  
pp. 2433-2440 ◽  
Author(s):  
Phyllis Anne Kosen ◽  
Thomas E. Creighton ◽  
Elkan R. Blout
1976 ◽  
Vol 31 (1) ◽  
pp. 140-141 ◽  
Author(s):  
M. S. Kelkar ◽  
R. Shanker ◽  
G. V. Baxore

A linear combination of the effect of substituents on pre-equilibrium and subsequent rate limiting step, K and k respectively, describes the structure reactivity, relationship of the form log k/k0 = -2.17σ++ 3.3 σ, where former corresponds to V(V)-ketone complex and the latter its rate limiting disproportionation


1978 ◽  
Vol 39 (02) ◽  
pp. 496-503 ◽  
Author(s):  
P A D’Amore ◽  
H B Hechtman ◽  
D Shepro

SummaryOrnithine decarboxylase (ODC) activity, the rate-limiting step in the synthesis of polyamines, can be demonstrated in cultured, bovine, aortic endothelial cells (EC). Serum, serotonin and thrombin produce a rise in ODC activity. The serotonin-induced ODC activity is significantly blocked by imipramine (10-5 M) or Lilly 11 0140 (10-6M). Preincubation of EC with these blockers together almost completely depresses the 5-HT-stimulated ODC activity. These observations suggest a manner by which platelets may maintain EC structural and metabolic soundness.


Diabetes ◽  
1993 ◽  
Vol 42 (2) ◽  
pp. 296-306 ◽  
Author(s):  
D. C. Bradley ◽  
R. A. Poulin ◽  
R. N. Bergman

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